http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Johns Hopkins researchers say they have discovered specific chemical alterations in two genes that, when present during pregnancy, reliably predict whether a woman will develop postpartum depression. http://medicalxpress.com/news/2013-05-genetic-predictors-postpartum-depression-uncovered.html Psychology & Psychiatry Tue, 21 May 2013 04:00:02 EST news288291866 The spleen is rarely noticed, until it is missing. In children born without this organ, that doesn't happen until they become sick with life-threatening bacterial infections. An international team of researchers led by scientists from Rockefeller's St. Giles Laboratory of Human Genetics and Infectious Diseases has now identified the defective gene responsible for this rare disorder. The findings, reported today in Science Express, may lead to new diagnostic tests and raises new questions about the role of this gene in the body's protein-making machinery. http://medicalxpress.com/news/2013-04-scientists-gene-mutation-children-born.html Genetics Thu, 11 Apr 2013 14:00:08 EST news284907208 Studies screening the genome of hundreds of thousands of individuals (known as Genome-wide association studies or GWAS) have linked more than 100 regions in the genome to the risk of developing cardiovascular disease. Researchers from the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg, through the joint Molecular Medicine Partnership Unit (MMPU), are taking these results one step further by pinpointing the exact genes that could have a role in the onset of the disease. Their findings are published today in the PLoS Genetics. http://medicalxpress.com/news/2013-02-zeroing-heart-disease-strategy-genes.html Genetics Thu, 28 Feb 2013 17:15:35 EST news281294128 (Medical Xpress)—Early diagnosis and intervention for ADHD, autism and schizophrenia could be made possible after Australian scientists discovered the molecular networks in the brain showing psychiatric and developmental disorders. http://medicalxpress.com/news/2013-02-reveals-molecular-networks-mental-health.html Psychology & Psychiatry Wed, 27 Feb 2013 10:40:01 EST news281183424 (Medical Xpress)—More than 45,000 people of European and Asian ancestry have taken part in a big study to gain a better understanding of the genetics behind the world's most common eye disorder. http://medicalxpress.com/news/2013-02-clear-sighted-genes-eye-problems.html Genetics Thu, 21 Feb 2013 06:18:11 EST news280649885 Fetal alcohol syndrome is the leading preventable cause of developmental disorders in developed countries. And fetal alcohol spectrum disorder (FASD), a range of alcohol-related birth defects that includes fetal alcohol syndrome, is thought to affect as many as 1 in 100 children born in the United States. http://medicalxpress.com/news/2013-02-pathway-linked-fetal-alcohol-molecular.html Medical research Wed, 20 Feb 2013 16:48:42 EST news280601315 Mutations in single genes can cause catastrophic diseases, such as Huntington's Disease or sickle cell anemia. However, many conditions, including cancer, diabetes and birth defects are multigenic, arising from the collective failure of the function of more than one gene. http://medicalxpress.com/news/2013-01-deficiencies-genes-synergize-halt-formation.html Genetics Thu, 31 Jan 2013 10:51:08 EST news278851794 New research is revealing how red blood cells are made and how the body regulates the amount of haemoglobin that is packaged in red blood cells at any time. Genomic analysis techniques have doubled the number of genetic regions that are likely to be involved in red blood cell formation and subsequent study using fruit flies has given insights into what these regions do. http://medicalxpress.com/news/2012-12-genetic-regions-red-blood-cell.html Genetics Wed, 05 Dec 2012 13:00:06 EST news273929927 (HealthDay)—Genotyping of two genetic risk alleles can be used to estimate the long-term risk of early and late age-related macular degeneration (AMD), but knowing the phenotype is important in assessing risk when early AMD is present, according to a study published online Nov. 9 in the Archives of Ophthalmology. http://medicalxpress.com/news/2012-11-genotyping-ids-long-term-macular-degeneration.html Ophthalmology Tue, 13 Nov 2012 18:10:04 EST news272048480 (HealthDay)—Meta-analyses have identified an additional 16 loci with genome-wide significance for coronary artery disease (CAD), according to research presented at the annual meeting of the American Society of Human Genetics, held from Nov. 6 to 10 in San Francisco. http://medicalxpress.com/news/2012-11-ashg-additional-loci-idd-coronary.html Genetics Fri, 09 Nov 2012 09:43:55 EST news271676627 Research findings confirming that de novo mutations represent a major cause of previously unexplained intellectual disability were presented on Nov. 8 at the American Society of Human Genetics 2012 meeting in San Francisco. http://medicalxpress.com/news/2012-11-exome-sequencing-potential-diagnostic-assay.html Genetics Thu, 08 Nov 2012 13:30:03 EST news271583263 Scientists at the Montreal Neurological Institute and Hospital – The Neuro, McGill University working with a team at Oxford University have uncovered the genetic defect underlying a group of rare genetic disorders. http://medicalxpress.com/news/2012-10-scientists-gene-rare-disorders.html Genetics Tue, 09 Oct 2012 11:57:31 EST news269002645 Dissecting the mechanisms implicated in cell architecture should provide new insights for understanding development and tissue morphogenesis in general. An European study focused on the role of the Notch signalling pathway in regulating cell architecture. http://medicalxpress.com/news/2012-10-notch-cell-architecture-potential-implications.html Cancer Fri, 05 Oct 2012 08:25:25 EST news268644288 New research published Online First in The Lancet suggests that a high proportion of severe intellectual disability results from genetic causes that are not inherited. These findings are good news for parents, indicating a low risk of passing on the disorder to further children. http://medicalxpress.com/news/2012-09-large-proportion-intellectual-disability-genetically.html Genetics Wed, 26 Sep 2012 18:30:01 EST news267895320 The genetics of a patient affects the extent of septic shock development and response to therapy. European researchers have identified genes related to sepsis in a study group of more than 2,500 patients in Europe. http://medicalxpress.com/news/2012-09-genetic-fatalities-due-sepsis.html Medical research Mon, 17 Sep 2012 08:26:23 EST news267089175 The genetics of autism is complex and possibly influenced by mutations with very large effects. EU genomics research has found more candidate genes that increase susceptibility to the condition. http://medicalxpress.com/news/2012-09-genetics-autism.html Autism spectrum disorders Fri, 14 Sep 2012 09:28:48 EST news266833722 Tyrosine kinase inhibitors (TKIs) kill cancerous cells by inducing programmed cell death. They are of enormous therapeutic benefit to patients with chronic myeloid leukemia (CML) and certain types of lung cancer, but their effectiveness may vary from individual to individual. Previous studies have estimated that one in five patients finds TKIs to be ineffective. An international team of researchers including Yijun Ruan and Axel Hillmer at the A*STAR Genome Institute of Singapore, Sin Tiong Ong and King Pan Ng at the Duke-National University of Singapore Graduate Medical School, Charles Chuah at the Department of Haematology, Singapore General Hospital and Darren Wan-Teck Lim at the National Cancer Centre has now identified a common genetic variation linked with resistance to TKIs. http://medicalxpress.com/news/2012-08-genetic-variation-common-east-asian.html Genetics Thu, 02 Aug 2012 08:19:37 EST news263112686 A team led by scientists at Cold Spring Harbor Laboratory (CSHL) publishes research today indicating a striking association between genes found disrupted in children with autism and genes that are targets of FMRP, the protein generated by the gene FMR1, whose dysfunction causes Fragile-X syndrome. The new study appears online April 25 in the journal Neuron. http://medicalxpress.com/news/2012-04-link-fragile-x-gene-mutations-autism.html Genetics Wed, 25 Apr 2012 12:01:11 EST news254574039 Evidence that the most deadly species of malaria parasite, Plasmodium falciparum, is becoming resistant to the front line treatment for malaria on the border of Thailand and Myanmar (Burma) is reported in The Lancet today. This increases concern that resistance could now spread to India and then Africa as resistance to other antimalarial drugs has done before. Eliminating malaria might then prove impossible. http://medicalxpress.com/news/2012-04-artemisinin-resistant-untreatable-malaria-rapidly-thailand-myanmar.html Diseases, Conditions, Syndromes Thu, 05 Apr 2012 14:00:01 EST news252845757 Researchers at MassGeneral Hospital for Children (MGHfC), The Jackson Laboratory and other institutes have uncovered 27 new candidate genes for congenital diaphragmatic hernia (CDH), a common and often deadly birth defect. http://medicalxpress.com/news/2012-02-clues-common-birth-defect-gene.html Genetics Mon, 06 Feb 2012 15:00:12 EST news247755783 New research led by The Hospital for Sick Children (SickKids) and the University of Toronto has identified more genes in attention deficit hyperactivity disorder (ADHD) and shows that there is an overlap between some of these genes and those found in other neuropsychiatric conditions such as autism spectrum disorder (ASD). The study is published in the August 10 advance online edition of Science Translational Medicine. http://medicalxpress.com/news/2011-08-adhd-genes-links-susceptibility-autism.html Genetics Wed, 10 Aug 2011 17:10:12 EST news232214970 Researchers at UT Southwestern Medical Center say there are at least 70 genetic mutations involved in the formation of colon cancer, far more than scientists previously thought. http://medicalxpress.com/news/2011-07-reveals-significantly-genetic-mutations-colon.html Cancer Mon, 18 Jul 2011 04:10:03 EST news230180333 An international research team, co-led by scientists at Mayo Clinic's campus in Florida, have discovered three potential susceptibility genes for development of progressive supranuclear palsy (PSP), a rare neurodegenerative disease that causes symptoms similar to those of Parkinson's disease but is resistant to Parkinson's medications. Their report is being published online June 19 in Nature Genetics. http://medicalxpress.com/news/2011-06-susceptibility-genes-neurodegenerative-disorder.html Genetics Sun, 19 Jun 2011 13:00:29 EST news227706753 By dividing individuals with autism spectrum disorders (ASD) into four subtypes according to similarity of symptoms and reanalyzing existing genome-wide genetic data on these individuals vs. controls, researchers at the George Washington University School of Medicine and Health Sciences have identified 18 novel and highly significant genetic markers for ASD. http://medicalxpress.com/news/2011-04-subtype-dependent-genetic-variants-autism-spectrum.html Genetics Wed, 27 Apr 2011 17:16:38 EST news223143369