http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment of certain cancers. http://medicalxpress.com/news/2013-05-wip1-cancer-treatment.html Cancer Mon, 06 May 2013 12:00:04 EST news287056946 Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes. Results presented at the AACR Annual Meeting 2013 show that in lung and bladder cancers, genes related to the regulation of the cell cycle are associated with poor patient outcomes. http://medicalxpress.com/news/2013-04-misregulated-genes-common-tobacco-related-cancers.html Cancer Tue, 09 Apr 2013 09:39:36 EST news284719159 Tumor suppression, the family business of the sibling genes p53, p63 and p73, is undermined from within by the split personalities of p63 and p73, which each produce protein forms that not only block the work of the other two genes but also shut down its own cancer-stifling fraternal twin. http://medicalxpress.com/news/2013-04-key-back-up-tumor-fighter-p53.html Cancer Mon, 08 Apr 2013 15:00:01 EST news284644382 Bringing scientists a step closer to new treatments for diabetes, researchers at the University of Pittsburgh School of Medicine and The Mount Sinai Medical Center have discovered a novel mechanism that regulates the replication of insulin-producing beta cells in the pancreas. The findings were recently published online ahead of print in Diabetes, a journal of the American Diabetes Association. http://medicalxpress.com/news/2013-03-mechanism-replication-insulin-producing-beta-cells.html Diabetes Tue, 26 Mar 2013 11:56:23 EST news283517776 The two infamous proteins, amyloid-beta (Aβ) and tau, that characterize advanced Alzheimer's disease (AD), start healthy neurons on the road to cell death long before the appearance of the deadly plaques and tangles by working together to reactivate the supposedly blocked cell cycle in brain cells, according to research presented on Dec. 17 at the American Society for Cell Biology's Annual Meeting in San Francisco. http://medicalxpress.com/news/2012-12-neurons-die-alzheimer-faulty-cell.html Alzheimer's disease & dementia Mon, 17 Dec 2012 13:00:10 EST news274961394 Milk consumption has been linked to improved health, with decreased risks of diabetes, metabolic syndrome, and colon cancer. A group of scientists in Sweden found that lactoferricin4-14 (Lfcin4-14), a milk protein with known health effects, significantly reduces the growth rate of colon cancer cells over time by prolonging the period of the cell cycle before chromosomes are replicated. In a new study, investigators report that treatment with Lfcin4-14 reduced DNA damage in colon cancer cells exposed to ultraviolet (UV) light. Their results are published in the October issue of the Journal of Dairy Science. http://medicalxpress.com/news/2012-10-cancer-protective-properties.html Cancer Wed, 03 Oct 2012 16:48:55 EST news268501267 Weill Cornell Medical College researchers have devised an innovative boxer-like strategy, based on the serial use of two anti-cancer drugs, to deliver a one-two punch to first weaken the defenses of multiple myeloma and then deliver the final knock-out punch to win the fight. http://medicalxpress.com/news/2012-06-cancer-cell-weakens-defeats-multiple.html Cancer Thu, 21 Jun 2012 14:20:36 EST news259507229 A study by Travis H. Stracker, researcher at the Institute for Research in Biomedicine (IRB Barcelona), in collaboration with scientists at the Memorial Sloan Kettering Cancer Center (MSKCC) in New York, reveals new information about the origin of tumors. http://medicalxpress.com/news/2012-06-uncover-clues-cancer.html Cancer Wed, 06 Jun 2012 10:41:35 EST news258198088 Alterations in the formation of ribosomes (the elements of the cell where proteins are made) cause the induction of p53 protein and cell cycle disruption. This process is crucial to understand fundamental biological processes and the emergence of various diseases. Now, scientists at the Bellvitge Biomedical Research Institute (IDIBELL) have found that this response is achieved independently, depending on which subunit of the ribosome (40S and 60S) is impaired, by the joint action of two proteins of the ribosome. The research results are published in the latest issue of the journal Genes and Development. http://medicalxpress.com/news/2012-05-ribosome-subunits-cell.html Genetics Tue, 22 May 2012 10:39:10 EST news256901871 The American Cancer Society estimates that 44,000 new cases of pancreatic cancer will be diagnosed this year and that 37,000 people will die from the disease. These are not strong odds. A new drug, rigosertib, allows pancreatic cancer cells to rush through replication – and then stops them cold, killing them in in the middle of a step called M phase. Healthy cells that don't rush are unharmed. http://medicalxpress.com/news/2012-03-tortoise-hare-drug-cancer-cells.html Cancer Fri, 02 Mar 2012 09:49:17 EST news249904132 Researchers at Virginia Commonwealth University Massey Cancer Center have developed a novel treatment strategy for multiple myeloma that delivers a deadly one-two blow to kill even the most inactive, or cytokinetically quiescent, cells. Because multiple myeloma can rest in a non-proliferative state for extended periods of time, this discovery may help to overcome a major hurdle to treating this fatal disease.   http://medicalxpress.com/news/2011-11-scientists-defeat-hurdle-eradicating-inactive.html Cancer Mon, 14 Nov 2011 09:37:51 EST news240485863 Stem cell researchers at UCLA have uncovered for the first time why adult human cardiac myocytes have lost their ability to proliferate, perhaps explaining why the human heart has little regenerative capacity. http://medicalxpress.com/news/2011-08-scientists-uncover-human-heart-regenerate.html Medical research Tue, 09 Aug 2011 09:38:21 EST news232101479 The embryonic nervous system is a hollow tube consisting of elongated neural progenitor cells, which extend from the inner to the outer surface of the tube. In a section inside the tube called the ventricular zone (VZ), these cells divide and produce immature neurons that migrate outwards. This involves well-characterized movements that are coupled to cell division. After a cell divides at the inner-most VZ region, the nuclei migrate to the outer region, where they synthesize new DNA before returning.  http://medicalxpress.com/news/2011-06-unraveling-ins-outs-brain.html Neuroscience Fri, 10 Jun 2011 10:33:40 EST news226920806 Clinical researchers at VCU Massey Cancer Center have successfully completed a Phase I clinical trial evaluating a combination of the drugs Bortezomib and Alvocidib in patients with relapsed or refractory blood cancers, paving the way for a Phase II clinical trial to test the safety and effectiveness of the new therapy. http://medicalxpress.com/news/2011-06-lab-clinic-therapy-blood-cancers.html Cancer Thu, 02 Jun 2011 17:24:01 EST news226254213