http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. It has long been known that cancer is a disease of aging, but a molecular link between the two has remained elusive. http://medicalxpress.com/news/2012-06-aging-cells-fuels-tumor-growth.html Cancer Thu, 14 Jun 2012 14:59:36 EST news258904683 A molecule thought to limit cell proliferation also helps cancer cells survive during initial tumor formation and when the wayward cells spread to other organs in the body, researchers at the University of Illinois at Chicago College of Medicine have found. http://medicalxpress.com/news/2012-06-key-enzyme-roles-friend-foe.html Medical research Thu, 14 Jun 2012 08:55:53 EST news258882913 (HealthDay) -- Perjeta (pertuzumab) has been approved by the U.S. Food and Drug Administration to treat people with HER2-positive late-stage breast cancer, the agency said in a news release. http://medicalxpress.com/news/2012-06-perjeta-advanced-breast-cancer.html Cancer Mon, 11 Jun 2012 14:00:06 EST news258640641 A phase I clinical trial examining the safety of combining temsirolimus and capecitabine in advanced malignancies suggests the two agents can be given safely to patients. In addition, the Georgetown Lombardi Comprehensive Cancer Center researchers conducting the study in cancer patients whose tumors have resisted multiple treatments say the combination demonstrates "promising evidence" of disease control and should be studied in a phase II trial. Their clinical findings and additional data from the study will be presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago, June 1 through 5, 2012. http://medicalxpress.com/news/2012-05-phase-temsirolimus-capecitabine-safe-positive.html Cancer Wed, 16 May 2012 18:00:03 EST news256406984 Apigenin, a natural substance found in grocery store produce aisles, shows promise as a non-toxic treatment for an aggressive form of human breast cancer, following a new study at the University of Missouri. MU researchers found apigenin shrank a type of breast cancer tumor that is stimulated by progestin, a synthetic hormone given to women to ease symptoms related to menopause. http://medicalxpress.com/news/2012-05-breast-cancer-effectively-chemical-celery.html Cancer Wed, 16 May 2012 09:20:14 EST news256378808 The human body does a great job of generating new cells to replace dead ones but it is not perfect. Cells need to communicate with or signal to each other to decide when to generate new cells. Communication or signaling errors in cells lead to uncontrolled cell growth and are the basis of many cancers. http://medicalxpress.com/news/2012-05-discovery-cell-melanoma.html Cancer Thu, 10 May 2012 13:25:06 EST news255875065 Researchers studying the molecular signals that drive a specific type of lymphoma have discovered a key biological pathway leading to this type of cancer. Cancerous cells have been described as being "addicted" to certain oncogenes (cancer-causing genes), and the new research may lay the groundwork for breaking that addiction and effectively treating aggressive types of B cell lymphoma. http://medicalxpress.com/news/2012-05-protein-cell-lymphoma.html Cancer Mon, 07 May 2012 16:02:43 EST news255625320 A Simon Fraser University researcher is among four scientists who argue that cholesterol may slow or stop cancer cell growth. They describe how cholesterol-binding proteins called ORPs may control cell growth in A Detour for Yeast Oxysterol Binding Proteins, a paper published in the latest issue of the Journal of Biological Chemistry. http://medicalxpress.com/news/2012-04-cancer-fighting-goodness-cholesterol.html Cancer Thu, 19 Apr 2012 16:20:02 EST news254070769 Removing a lipoprotein receptor known as SR-BI may help protect against breast cancer, as suggested by new findings presented at the American Association for Cancer Research Annual Meeting 2012 by Jefferson's Kimmel Cancer Center researchers. http://medicalxpress.com/news/2012-04-good-cholesterol-receptor-breast-cancer.html Cancer Tue, 03 Apr 2012 15:49:20 EST news252686774 The dietary supplement gamma-linoleic acid can inhibit the growth of a subset of pancreatic cancer cells and selectively promote cancer cell death in mice, a Mayo Clinic study has found. The supplement, a fatty acid also known as GLA, worked particularly well when combined with the chemotherapy drug gemcitabine, the researchers say. The findings were presented today by Mayo Clinic pathologist Ruth Lupu, Ph.D., at the American Association for Cancer Research (AACR) Annual Meeting 2012. http://medicalxpress.com/news/2012-04-nutritional-supplement-pancreatic-cancer-cells.html Cancer Tue, 03 Apr 2012 09:47:47 EST news252665248 (Medical Xpress) -- Later-stage cancers thrive by finding detours around roadblocks that cancer drugs put in their path, but a Purdue University biochemist is creating maps that will help drugmakers close more routes and develop better drugs. http://medicalxpress.com/news/2012-03-substrate-kinase-interactions-effective-cancer-drugs.html Cancer Tue, 27 Mar 2012 17:28:21 EST news252087997 Getting rid of a protein increases the birth of new nerve cells and shortens the time it takes for antidepressants to take effect, according to an animal study in the March 7 issue of The Journal of Neuroscience. The protein, neurofibromin 1, normally helps prevent uncontrolled cell growth. The findings suggest therapeutic strategies aimed at stimulating new nerve cell birth may help treat depression better than current antidepressants that commonly take several weeks to reach full efficacy. http://medicalxpress.com/news/2012-03-molecule-relief-depression.html Neuroscience Tue, 06 Mar 2012 17:00:10 EST news250263122 Mitochondria, tiny structures within each cell that regulate metabolism and energy use, may be a promising new target for cancer therapy, according to a new study. Manipulation of two biochemical signals that regulate the numbers of mitochondria in cells could shrink human lung cancers transplanted into mice, a team of Chicago researchers report in the journal FASEB. http://medicalxpress.com/news/2012-02-energy-network-cells-cancer-therapy.html Cancer Tue, 21 Feb 2012 11:00:01 EST news249043340 Research led by Wanguo Liu, PhD, Associate Professor of Genetics at LSU Health Sciences Center New Orleans, has identified a new protein critical to the development and growth of prostate cancer. The findings are published online in the Early Edition of Proceedings of the National Academy of Sciences, available the week of February 6, 2012. http://medicalxpress.com/news/2012-02-prostate-cancer-drug.html Cancer Mon, 06 Feb 2012 15:00:16 EST news247755688 Soy isoflavone supplements did not decrease breast cancer cell proliferation in a randomized clinical trial, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-02-soy-isoflavone-supplements-breast-cancer.html Cancer Fri, 03 Feb 2012 11:15:00 EST news247490093 The holidays are over, January has arrived, and many of us enter the New Year determined to live our lives a little healthier than last. http://medicalxpress.com/news/2012-01-spice-food-boost-disease-prevention-power.html Health Fri, 06 Jan 2012 14:50:02 EST news245078063 Lithocholic acid (LCA), naturally produced in the liver during digestion, has been seriously underestimated. A study published in the journal Oncotarget shows that LCA can kill several types of cancer cells, such as those found in some brain tumors and breast cancer. http://medicalxpress.com/news/2012-01-cancer-killing-compound-healthy-cells.html Cancer Wed, 04 Jan 2012 12:22:53 EST news244902162 Scientists have discovered a new way to target cancer through manipulating a master switch responsible for cancer cell growth. http://medicalxpress.com/news/2011-12-scientists-cancer.html Cancer Mon, 12 Dec 2011 12:48:14 EST news242916460 Precisely quantifying the amount of three different HER growth proteins, along with several other proteins believed linked to breast cancer, did not predict a patient's outcome after treatment for HER2-Positive Breast Cancer with Herceptin, say Mayo Clinic researchers. HER2-positive breast cancer gets its name from a protein called human epidermal growth factor receptor 2 that promotes cancer cell growth. http://medicalxpress.com/news/2011-12-proteins-outcome-herceptin-treatment-her2-positive.html Cancer Fri, 09 Dec 2011 03:00:01 EST news242620870 Obese patients with early-stage HER2-positive breast cancer may have worse outcomes than patients who are normal weight or overweight, Mayo Clinic researchers found in a study presented today at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium. HER2-positive breast cancer gets its name from a protein called human epidermal growth factor receptor 2 that promotes cancer cell growth. http://medicalxpress.com/news/2011-12-obese-patients-her2-positive-breast-cancer.html Cancer Thu, 08 Dec 2011 08:28:58 EST news242555331 Researchers at the University of California, San Diego School of Medicine and Kyushu University Medical School say a novel combination of a specific sugar molecule with a pair of cell-killing drugs prompts a wide variety of cancer cell types to kill themselves, a process called apoptosis or programmed cell death. http://medicalxpress.com/news/2011-11-drug-combo-multiple-cancers.html Cancer Wed, 16 Nov 2011 15:54:22 EST news240681255 The embryonic enzyme pyruvate kinase M2 (PKM2) has a well-established role in metabolism and is highly expressed in human cancers. Now, a team led by researchers at the University of Texas MD Anderson Cancer Center reports in advance online publication of the journal Nature that PKM2 has important non-metabolic functions in cancer formation. http://medicalxpress.com/news/2011-11-metabolic-protein-unexpected-role-tumor.html Cancer Sun, 06 Nov 2011 13:10:02 EST news239806111 Researchers may have found a specific dietary pattern linked to levels of C-peptide concentrations that increase a woman's risk for colorectal cancer. http://medicalxpress.com/news/2011-10-dietary-patterns-linked-colorectal-cancer.html Cancer Mon, 24 Oct 2011 17:57:29 EST news238697842 Post-menopausal women with high levels of hormones such as estrogen or testosterone are known to have a higher risk of breast cancer. New research published in BioMed Central's open access journal Breast Cancer Research looked at eight different sex and growth hormones and found that the risk of breast cancer increased with the number of elevated hormones - each additional elevated hormone level increased risk by 16%. http://medicalxpress.com/news/2011-10-elevated-hormone-breast-cancer.html Cancer Fri, 21 Oct 2011 03:26:12 EST news238385577 Antineoplastic agents such as immunotherapies and targeted therapies that specifically target signaling pathways in cancer cells are associated with thyroid dysfunction in 20%-50% of cancer patients taking them, which can adversely affect patients' quality of life, according to a study published Oct. 18 in the Journal of the National Cancer Institute. http://medicalxpress.com/news/2011-10-antineoplastic-agents-thyroid-dysfunction.html Cancer Tue, 18 Oct 2011 16:00:01 EST news238155456 It's a common belief that there's a link between chronic stress and an increased risk of cancer. In new research published online by the International Journal of Cancer, scientists at The University of Western Ontario have taken a step toward confirming that belief. http://medicalxpress.com/news/2011-09-stress-breast-cancer.html Cancer Tue, 20 Sep 2011 12:04:00 EST news235738987 Blocking the uptake of large amounts of cholesterol into brain cancer cells could provide a new strategy to battle glioblastoma, one of the most deadly malignancies, researchers at UCLA's Jonsson Comprehensive Cancer Center have found. http://medicalxpress.com/news/2011-09-cholesterol-deadly-brain-cancers.html Cancer Thu, 15 Sep 2011 14:07:20 EST news235314413 Researchers at Emory University School of Medicine have identified a new type of potential anticancer drug. The compound, named FOBISIN, targets 14-3-3 proteins, important for the runaway growth of cancer cells. http://medicalxpress.com/news/2011-09-x-ray-protein-probe-potential-anticancer.html Cancer Mon, 12 Sep 2011 15:52:51 EST news235061547 Scientists at Dana-Farber Cancer Institute and colleagues overseas have discovered a pair of backup circuits in cancer cells that enable the cells to dodge the effect of a widely used cancer drug. Jamming those circuits with targeted therapies may heighten or restore the drug's potency, according to a study published in the Sept. 7 issue of Science Translational Medicine. http://medicalxpress.com/news/2011-09-strategy-resistance-cancer-drug.html Cancer Wed, 07 Sep 2011 14:10:24 EST news234623401 One of the holy grails in diabetes research is to discover molecules that stimulate beta cell growth and to find drugs that target these molecules. Now, JDRF-funded researchers in collaboration with the pharmaceutical company Hoffmann-La Roche, have done both, discovering not only a protein that regulates beta cell growth, but also a chemical compound that stimulates it. The work appears in the September 7 issue of Cell Metabolism. http://medicalxpress.com/news/2011-09-scientists-uncover-ways-pancreatic-beta.html Medical research Tue, 06 Sep 2011 14:48:20 EST news234539287