http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Researchers at the University of Hawai'i Cancer Center have uncovered a novel mechanism that may lead to more selective ways to stop cancer cells from spreading. Associate Professor Joe W. Ramos PhD, a cancer biologist at the UH Cancer Center and his team have identified the role of the protein RSK2 in cancer cell migration, part of the process of cancer metastasis. http://medicalxpress.com/news/2013-02-protein-cancer.html Cancer Tue, 26 Feb 2013 09:39:27 EST news281093941 For the first time scientists studying the cellular processes underlying the body's response to healing have revealed how a flash of calcium is the very first step in repairing damaged tissue. The findings, published in Current Biology, could lead to new therapies that speed up the healing process following injury or surgery. http://medicalxpress.com/news/2013-02-scientists-calcium-trigger-immune-response.html Surgery Thu, 14 Feb 2013 11:40:01 EST news280063844 Researchers at Moffitt Cancer Center and colleagues at Wayne State University School of Medicine investigated the acidity in solid tumors to determine if pH levels play a role in cancer cell invasion in surrounding tissues. They found that an acidic microenvironment can drive cancer cells to spread and propose that neutralizing pH would inhibit further invasion, providing a therapeutic opportunity to slow the progression of cancers. http://medicalxpress.com/news/2013-01-tumor-cells-acidity-cell-invasion.html Cancer Fri, 25 Jan 2013 04:04:29 EST news278308881 Preliminary findings from the first trial of a new drug for patients with mesothelioma show that it has some success in preventing the spread of the deadly disease in patients lacking an active tumour suppressor gene called NF2. The study is presented at the 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland, today (Friday). http://medicalxpress.com/news/2012-11-mesothelioma-drug-disease-patients-inactive.html Cancer Thu, 08 Nov 2012 18:00:02 EST news271613650 The stiffness of breast tissue is increasingly recognized as an important factor explaining the onset of breast cancer. Stiffening induces molecular changes that promote cancerous behavior in cells. Bioengineering studies have found that breast cancer cells grown on a 3-D gel have enhanced cell replication and decreased organization as rigidity increases. These signals are probably coordinated by surface proteins that communicate with connective tissue, to regulate cell replication, death, and movement. However, very little is known about how stiffness or other physical characteristics of tissues contributes to cancer behavior in living animals. http://medicalxpress.com/news/2012-09-tension-gut-muscles-cell-invasion.html Cancer Fri, 07 Sep 2012 17:01:13 EST news266256043 A new study has identified a key mechanism that causes breast cancer to spread. The research, published by Cell Press on March 30th in the journal Molecular Cell, enhances our knowledge about the signals that drive cancer metastasis and identifies new therapeutic targets for a lethal form of invasive breast cancer that is notoriously resistant to treatment. http://medicalxpress.com/news/2012-03-mechanism-breast-cancer-invasive.html Cancer Thu, 29 Mar 2012 12:00:03 EST news252240001 Ovarian cancer is a major cause of death worldwide. Approximately 25,000 women will be diagnosed with ovarian cancer this year and 15,000 women will die from it in the United States alone. The novel anti-cancer drug diindolylmethane (DIM) has been shown in laboratory to inhibit the growth of ovarian cancer cells. New research published in BioMed Central's open access journal BMC Medicine has looked in detail at the action of DIM and showed that it works by blocking the activation and production of the transcription factor STAT3. DIM also enhances the anti-cancer effect of the platinum-based chemotherapy drug cisplatin. http://medicalxpress.com/news/2012-01-dimming-cancer-growth-stat.html Cancer Thu, 26 Jan 2012 04:22:24 EST news246774136 Oral Squamous Cell Carcinoma (OSCC) is responsible for nearly a quarter of all head and neck cancers. It is one of the leading causes of cancer death - largely due to the failure of current histological procedures in predicting the recurrence of the disease. New research published in BioMed Central's open access journal BMC Cancer shows that a four-gene signature may accurately predict which patients are at higher risk of OSCC recurrence. http://medicalxpress.com/news/2011-10-gene-signature-oral-cancer-recurrence.html Cancer Tue, 11 Oct 2011 04:10:14 EST news237525000 (Medical Xpress) -- Study uncovers several compounds that inhibit cancer cell invasion, but also reveals that cancer drug paclitaxel does the opposite -- it promotes cancer metastasis. http://medicalxpress.com/news/2011-07-high-throughput-screen-compounds-cancer-cell.html Cancer Tue, 26 Jul 2011 09:20:25 EST news230890805 Researchers at the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center, identified for the first time the key role specific microRNAs (miRNAs) play in melanoma metastasis to simultaneously cause cancer cells to invade and immunosuppress the human body's ability to fight abnormal cells. The new study is published in the July 11, 2011 issue of the journal Cancer Cell. http://medicalxpress.com/news/2011-07-key-role-micrornas-melanoma-metastasis.html Cancer Mon, 11 Jul 2011 17:36:16 EST news229624314