http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Alterations in the formation of ribosomes (the elements of the cell where proteins are made) cause the induction of p53 protein and cell cycle disruption. This process is crucial to understand fundamental biological processes and the emergence of various diseases. Now, scientists at the Bellvitge Biomedical Research Institute (IDIBELL) have found that this response is achieved independently, depending on which subunit of the ribosome (40S and 60S) is impaired, by the joint action of two proteins of the ribosome. The research results are published in the latest issue of the journal Genes and Development. http://medicalxpress.com/news/2012-05-ribosome-subunits-cell.html Genetics Tue, 22 May 2012 10:39:10 EST news256901871 A Simon Fraser University researcher is among four scientists who argue that cholesterol may slow or stop cancer cell growth. They describe how cholesterol-binding proteins called ORPs may control cell growth in A Detour for Yeast Oxysterol Binding Proteins, a paper published in the latest issue of the Journal of Biological Chemistry. http://medicalxpress.com/news/2012-04-cancer-fighting-goodness-cholesterol.html Cancer Thu, 19 Apr 2012 16:20:02 EST news254070769 As they work together to form body parts, cells in developing organisms communicate like workers at a construction site. The discovery of a new signaling molecule in flies by Brown University biologists not only helps explain how cells send many long-haul messages, but also provides new clues for researchers who study how human development goes awry, for instance in cases of cleft lip and palate. http://medicalxpress.com/news/2012-04-newly-protein-cells-tissues.html Medical research Mon, 02 Apr 2012 11:03:20 EST news252583391 Researchers at Fox Chase Cancer Center in Philadelphia have found that a protein associated with other cancers appears to also be important in head and neck cancer, and may consequently serve as a good target for new treatments. The findings will be reported at the AACR Annual Meeting 2012 on Sunday, April 1. http://medicalxpress.com/news/2012-04-protein-aurora-a-survival-neck-cancer.html Cancer Sun, 01 Apr 2012 14:40:20 EST news252510005 Researchers at Moffitt Cancer Center in Tampa, Fla., have discovered that the immune response regulator IKBKE (serine/threonine kinase) plays two roles in tobacco-related non-small cell lung cancers. Tobacco carcinogens induce IKBKE and, in turn, IKBKE induces chemotherapy resistance. http://medicalxpress.com/news/2012-02-important-role-tobacco-related-lung-cancers.html Cancer Thu, 09 Feb 2012 12:55:37 EST news248014519 In a study published last week in the prestigious Proceedings of the National Academy of Sciences of the United States of America, a team led by Dr. Vincent Poitout of the University of Montreal Hospital Research Centre (CRCHUM)* has made an important step forward in understanding how insulin secretion is regulated in the body. This discovery has important implications for drugs currently in development to treat Type 2 diabetes, a disease which is diagnosed every 10 seconds somewhere throughout the world. http://medicalxpress.com/news/2012-02-pave-treatment-diabetes.html Diabetes Tue, 07 Feb 2012 10:12:52 EST news247831963 A mutant protein found in nearly all pancreatic cancers plays a role not only in the cancer's development but in its continued growth, according to a new study from University of Michigan Comprehensive Cancer Center researchers. The finding suggests a possible target for developing new ways to treat this deadly disease. http://medicalxpress.com/news/2012-01-gene-linked-pancreatic-cancer-growth.html Cancer Tue, 31 Jan 2012 11:08:43 EST news247230516 A new study in the Journal of General Physiology uses state-of-the-art fluorescence microscopy to provide a striking 3-D picture of how class V myosins (myoV) "walk" along their actin track. http://medicalxpress.com/news/2012-01-picture-myov-actin-tracks.html Medical research Mon, 30 Jan 2012 12:00:02 EST news247144773 Most research on glioblastoma development, a complicated tumor of the brain with a poor prognosis, has focused on the gene transcription level, but scientists suggest that post-transcriptional regulation could be equally or even more important. http://medicalxpress.com/news/2012-01-scientists-uncover-mechanism-glioblastoma.html Cancer Wed, 18 Jan 2012 03:46:26 EST news246080765 (Medical Xpress) -- Scientists at the Friedrich Miescher Institute for Biomedical Research (FMI) of the Novartis Research Foundation have elucidated the mechanisms underlying the repair of UV-induced damage in DNA, which frequently causes skin cancer. The protein structures additionally determined by these researchers will improve our understanding of how the body protects itself against skin cancer. These studies lay the foundations for the development of a new class of anti cancer agents. The findings were published today in Cell. http://medicalxpress.com/news/2011-11-internal-skin-cancer-uv.html Cancer Thu, 24 Nov 2011 07:55:16 EST news241343677 The influenza virus remains a worldwide threat to humans, causing an average of 36,000 deaths and 200,000 hospitalizations each year in the United States alone. As health care professionals prepare for another flu season, a University of Missouri scientist is studying how two enzymes could be used to stop the virus in its tracks. http://medicalxpress.com/news/2011-11-mu-scientist-eyeing-enzymes-flu.html Medical research Thu, 17 Nov 2011 10:21:38 EST news240747681 (Medical Xpress) -- The future of drug design lies in developing therapies that can target specific cellular processes without causing adverse reactions in other areas of the nervous system. Scientists at the Universities of Bristol and Liège in Belgium have discovered how to design drugs to target specific areas of the brain. http://medicalxpress.com/news/2011-11-scientists-drugs-nerve-cells.html Medical research Thu, 10 Nov 2011 07:34:09 EST news240132839 A vitamin B6 derivative may help slow or prevent the progression of mild kidney disease in patients with diabetes, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The drug may benefit increasing numbers of patients as the prevalence of diabetes rises. http://medicalxpress.com/news/2011-10-vitamin-derivative-diabetics-mild-kidney.html Diseases, Conditions, Syndromes Thu, 27 Oct 2011 17:32:17 EST news238955512 Antineoplastic agents such as immunotherapies and targeted therapies that specifically target signaling pathways in cancer cells are associated with thyroid dysfunction in 20%-50% of cancer patients taking them, which can adversely affect patients' quality of life, according to a study published Oct. 18 in the Journal of the National Cancer Institute. http://medicalxpress.com/news/2011-10-antineoplastic-agents-thyroid-dysfunction.html Cancer Tue, 18 Oct 2011 16:00:01 EST news238155456 A new study describes how hyperactivation of AMP-activated protein kinase (AMPK) promotes neurodegeneration in Huntington's disease (HD). The article appears online on July 18, 2011, in The Journal of Cell Biology. http://medicalxpress.com/news/2011-07-ampk-amplifies-huntington-disease.html Medical research Mon, 18 Jul 2011 12:28:15 EST news230210876 Biomedical research at Arizona State University will be boosted with support from the American Heart Association for the work of three bioengineers. http://medicalxpress.com/news/2011-06-asu-bioengineers-cardiovascular-health.html Cardiology Tue, 28 Jun 2011 16:28:47 EST news228497287 (Medical Xpress) -- In a new study published in Nature Neuroscience, a team of researchers revealed the discovery of a key protein necessary for nerve repair and could lead to the development of a treatment for brain injuries due to a lack of oxygen, such a cerebral palsy, as well as multiple sclerosis, an autoimmune disease that affects adults all over the world. http://medicalxpress.com/news/2011-06-infant-brain-injuries-cerebral-palsy.html Neuroscience Mon, 27 Jun 2011 06:20:01 EST news228366899 Research presented at SNM's 58th Annual Meeting highlights molecular imaging's diagnostic potential for patients with fever of unknown origin. Persistent fever can be a warning sign for a range of diseases that could be dangerous if left untreated. A single, full-body molecular imaging scan may give physicians everything they need to narrow down the cause and determine appropriate treatment. http://medicalxpress.com/news/2011-06-molecular-imaging-fast-effective-diagnosis.html Cancer Mon, 06 Jun 2011 23:40:02 EST news226584833