http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor or stem cells—important for repair and regeneration of skeletal muscle and maintenance of healthy fat tissue—are subject to cellular senescence, and that clearance of these cells limits age-related deterioration of these tissues. The findings appear today online in the journal Cell Reports. http://medicalxpress.com/news/2013-04-stem-cell-senescence-aging.html Medical research Thu, 18 Apr 2013 12:42:21 EST news285507734 In a study published in the January 18 issue of Cell, researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have developed a new method to visualize aging and tumor growth in mice using a gene closely linked to these processes. http://medicalxpress.com/news/2013-01-scientists-luminescent-mice-track-cancer.html Medical research Thu, 17 Jan 2013 13:01:58 EST news277650107 Drugs that are used in the clinic to treat some forms of breast and kidney cancer and that work by inhibiting the signaling molecule mTORC1 might have utility in treating some of the more than 15 percent of human cancers driven by alterations in the Myc gene, according to data from a preclinical study published in Cancer Discovery, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-12-hard-to-treat-myc-driven-cancers-susceptible-drug.html Cancer Fri, 14 Dec 2012 10:00:01 EST news274695612 Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now identified a previously unknown mechanism in the regulation of OIS. This study is published online in advance of the January issue of The American Journal of Pathology. http://medicalxpress.com/news/2012-12-previously-unknown-mechanism-oncogene-induced-senescence.html Cancer Wed, 12 Dec 2012 00:00:02 EST news274462449 Researchers at Mayo Clinic have shown that eliminating cells that accumulate with age could prevent or delay the onset of age-related disorders and disabilities. The study, performed in mouse models, provides the first evidence that these "deadbeat" cells could contribute to aging and suggests a way to help people stay healthier as they age. The findings appear in the journal Nature, along with an independent commentary on the discovery. http://medicalxpress.com/news/2011-11-tactic-age-related-disorders.html Medical research Wed, 02 Nov 2011 14:00:06 EST news239461095 Malignant melanoma is a highly aggressive and notoriously chemoresistant form of cancer. In a new paper, Ohanna et al. reveal that anti-melanoma drugs may, paradoxically, induce a senescence-associated secretory profile ("secretome") that can ultimately promote metastasis and contribute to melanoma relapse. http://medicalxpress.com/news/2011-06-genetics-melanoma-chemoresistance.html Cancer Mon, 06 Jun 2011 03:42:03 EST news226550507