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The lipidation states (or modifications) in certain proteins in the brain that are related to the development of Alzheimer disease appear to differ depending on genotype and cognitive diseases, and levels of these protein and peptides appear to be influenced by diet, according to a report published Online First by JAMA Neurology, a JAMA Network publication. http://medicalxpress.com/news/2013-06-dietary-intervention-proteins-brain.html Neuroscience Mon, 17 Jun 2013 16:00:03 EST news290695554 Scientists at Washington University School of Medicine in St. Louis have measured a significant and potentially pivotal difference between the brains of patients with an inherited form of Alzheimer's disease and healthy family members who do not carry a mutation for the disease. http://medicalxpress.com/news/2013-06-alzheimer-brain-humans.html Alzheimer's disease & dementia Wed, 12 Jun 2013 14:00:02 EST news290255398 (Medical Xpress)—Scientists at Washington University School of Medicine in St. Louis have helped identify many of the biomarkers for Alzheimer's disease that could potentially predict which patients will develop the disorder later in life. Now, studying spinal fluid samples and health data from 201 research participants at the Charles F. and Joanne Knight Alzheimer's Disease Research Center, the researchers have shown the markers are accurate predictors of Alzheimer's years before symptoms develop. http://medicalxpress.com/news/2013-05-alzheimer-markers-mental-decline.html Alzheimer's disease & dementia Tue, 14 May 2013 06:48:36 EST news287732906 A highly underutilized anesthesia technique called neuraxial anesthesia, also known as spinal or epidural anesthesia, improves outcomes in patients undergoing hip or knee replacement, according to a new study by researchers at Hospital for Special Surgery. The study, which appears in the May issue of the journal Anesthesiology, found that neuraxial anesthesia, a type of regional anesthesia, reduced morbidity, mortality, length of hospital stay and costs when compared with general anesthesia. http://medicalxpress.com/news/2013-04-regional-anesthesia-technique-significantly-outcomes.html Surgery Wed, 01 May 2013 00:00:07 EST news286563849 Researchers at Washington University School of Medicine in St. Louis have identified a new set of genetic markers for Alzheimer's that point to a second pathway through which the disease develops. http://medicalxpress.com/news/2013-04-genetic-markers-id-alzheimer-pathway.html Alzheimer's disease & dementia Thu, 04 Apr 2013 12:32:42 EST news284297477 (Medical Xpress)—Washington University School of Medicine in St. Louis is playing a leading role in one of the National Institutes of Health's (NIH) first clinical trials to improve treatments for rare and neglected diseases. http://medicalxpress.com/news/2013-04-drug-niemann-pick-crare-deadly-childhood.html Diseases, Conditions, Syndromes Wed, 03 Apr 2013 08:29:54 EST news284196165 A new, implantable device for treating chronic pain passes an important safety test. http://medicalxpress.com/news/2013-03-relieving-chronic-pain.html Medical research Mon, 25 Mar 2013 11:14:47 EST news283428879 A new mobile 'app', downloadable free of charge, will assist with the training of future neurosurgeons, and is just one of a stream of programmes being developed, adapting visual computing and three dimensional realities to provide cost-effective virtual learning for a range of medical procedures. http://medicalxpress.com/news/2013-01-virtual-ipad-app-future-neurosurgeons.html Surgery Wed, 09 Jan 2013 09:23:13 EST news276945779 When trying to determine the root cause of a person's dementia, using an MRI can effectively and non-invasively screen patients for Alzheimer's disease or Frontotemporal Lobar Degeneration (FTLD), according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania. Using an MRI-based algorithm effectively differentiated cases 75 percent of the time, according to the study, published in the December 26th, 2012, issue of Neurology, the medical journal of the American Academy of Neurology. The non-invasive approach reported in this study can track disease progression over time more easily and cost-effectively than other tests, particularly in clinical trials testing new therapies. http://medicalxpress.com/news/2012-12-mri-screen-patients-alzheimer-disease.html Alzheimer's disease & dementia Wed, 26 Dec 2012 16:00:06 EST news275576983 Researchers at Emory University School of Medicine have discovered that dozens of adults with an elevated need for sleep have a substance in their cerebrospinal fluid that acts like a sleeping pill. http://medicalxpress.com/news/2012-11-antidote-hypersomnia.html Medical research Wed, 21 Nov 2012 14:00:02 EST news272725331 Researchers have found the earliest signs of Alzheimer's disease yet detected in a group of people with a rare, inherited form of the disease, according to two Articles published in The Lancet Neurology. The findings raise important questions about scientists' understanding of how, and why, Alzheimer's disease progresses, and could ultimately lead to improved early detection and better clinical trials of preventative treatments. http://medicalxpress.com/news/2012-11-earliest-alzheimer-people-genetic-mutation.html Alzheimer's disease & dementia Mon, 05 Nov 2012 18:30:01 EST news271337410 Using regional anesthesia rather than general anesthesia reduces the need for blood transfusions in patients undergoing bilateral total knee replacement, according to a new study by researchers at Hospital for Special Surgery, in New York City. http://medicalxpress.com/news/2012-10-anesthesia-affects-outcomes-bilateral-knee.html Surgery Fri, 26 Oct 2012 13:30:02 EST news270474763 Analysis of specific biomarkers in a cerebrospinal fluid sample can differentiate patients with Alzheimer's disease from those with other types of dementia. The method, which is being studied by researchers at Sahlgrenska Academy, may eventually permit earlier detection of Alzheimer's disease. http://medicalxpress.com/news/2012-10-biomarkers-cerebrospinal-fluid-patients-alzheimer.html Alzheimer's disease & dementia Mon, 22 Oct 2012 10:10:07 EST news270118611 Sleep disruptions may be among the earliest indicators of Alzheimer's disease, scientists at Washington University School of Medicine in St. Louis report Sept. 5 in Science Translational Medicine. http://medicalxpress.com/news/2012-09-problems-early-alzheimer.html Alzheimer's disease & dementia Wed, 05 Sep 2012 14:00:01 EST news266057923 (HealthDay)—Levels of five different cerebrospinal fluid (CSF) biomarkers are able to improve differentiation between common dementia and parkinsonian disorders, according to a study published online Aug. 27 in the Archives of Neurology. http://medicalxpress.com/news/2012-08-csf-markers-differentiate-dementia-parkinsonism.html Neuroscience Tue, 28 Aug 2012 12:50:01 EST news265375345 (HealthDay) -- In dominantly inherited Alzheimer's disease, clinical and biomarker changes occur decades before the expected onset of disease symptoms, according to a study published online July 11 in the New England Journal of Medicine. http://medicalxpress.com/news/2012-07-pathophysiology-id-rare-early-alzheimer.html Alzheimer's disease & dementia Thu, 12 Jul 2012 04:31:28 EST news261286120 Researchers at the University of Michigan have found that the Apple iPad 2 can interfere with settings of magnetically programmable shunt devices, which are often used to treat children with hydrocephalus. The iPad 2 contains magnets that can change valve settings in the shunt if the tablet computer is held too close to the valve (within 2 inches). Such a change may result in shunt malfunction until the problem is recognized and the valve adjusted to the proper setting. Patients and their caregivers should monitor use of the tablet computer to ensure that no change is made to the valve settings. The results of this study can be found in the article "Programmable shunt valve affected by exposure to a tablet computer. Laboratory investigation," by Strahle and colleagues, published in the August 2012 issue of the Journal of Neurosurgery: Pediatrics and available online today. http://medicalxpress.com/news/2012-06-tablet-magnetically-programmable-shunt-valves.html Neuroscience Tue, 26 Jun 2012 10:00:05 EST news259923228 A team led by investigators at the Stanford University School of Medicine has found that the most common genetic risk factor for Alzheimer's disease disrupts brain function in healthy older women but has little impact on brain function in healthy, older men. Women harboring the gene variant, known to be a potent risk factor for Alzheimer's disease, show brain changes characteristic of the neurodegenerative disorder that can be observed before any outward symptoms manifest. http://medicalxpress.com/news/2012-06-alzheimer-gene-disrupts-brain-function.html Alzheimer's disease & dementia Tue, 12 Jun 2012 17:00:18 EST news258721102 Immunotherapy with the antibody bapineuzumab in patients with mild to moderate Alzheimer disease resulted in decreases in a cerebrospinal fluid biomarker, which may indicate downstream effects on the degenerative process, according to a report published Online First by Archives of Neurology. http://medicalxpress.com/news/2012-04-immunotherapy-cerebrospinal-fluid-biomarkers-patients.html Alzheimer's disease & dementia Mon, 02 Apr 2012 16:00:06 EST news252590312 A new marker of Alzheimer's disease can predict how rapidly a patient's memory and other mental abilities will decline after the disorder is diagnosed, researchers at Washington University School of Medicine in St. Louis have found. http://medicalxpress.com/news/2012-03-alzheimer-marker-strongly-mental-decline.html Alzheimer's disease & dementia Mon, 05 Mar 2012 16:00:06 EST news250174495 Cerebrospinal fluid levels of Aβ42 appear to be decreased at least five to 10 years before some patients with mild cognitive impairment develop Alzheimer disease (AD) dementia whereas other spinal fluid levels seem to be later markers of disease, according to a report in the January issue of Archives of General Psychiatry. http://medicalxpress.com/news/2012-01-cerebrospinal-fluid-onset-alzheimer-dementia.html Psychology & Psychiatry Mon, 02 Jan 2012 16:00:10 EST news244731611 Analysis of the cerebrospinal fluid can detect whether a person has Alzheimer's disease before symptoms appear. Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden, have studied biomarkers that offer more reliable diagnosis and, in the longer term, the possibility of effective new treatments. http://medicalxpress.com/news/2011-12-csf-alzheimer-early.html Diseases, Conditions, Syndromes Tue, 20 Dec 2011 13:13:51 EST news243609196 When the virus that causes AIDS infects the central nervous system, it can lead to the development of a severe neurological disease called HIV-associated dementia (HAD). http://medicalxpress.com/news/2011-10-distinct-aids-viruses-cerebrospinal-fluid.html HIV & AIDS Thu, 06 Oct 2011 17:00:06 EST news237127776 Differentiating between the various forms of dementia is crucial for initiating appropriate treatment. Researchers at the Sahlgrenska Academy have discovered that the underlying diseases leave different "fingerprints" in the cerebrospinal fluid, paving the way for more reliable diagnoses. http://medicalxpress.com/news/2011-10-biological-fingerprints-diagnosis-dementia.html Diseases, Conditions, Syndromes Tue, 04 Oct 2011 15:36:25 EST news236961372 Researchers at the Sahlgrenska Academy, University of Gothenburg, have identified a series of novel proteins in human cerebrospinal fluid. The proteins, which carry specific sugar molecules, are found in greater concentrations in patients with dementia caused by Alzheimer's disease than in patients with dementia caused by other diseases. This gives hope for new forms of treatment in the future. http://medicalxpress.com/news/2011-06-clues-alzheimer-disease.html Diseases, Conditions, Syndromes Thu, 30 Jun 2011 11:37:47 EST news228652650