http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A novel, targeted approach to chemotherapy that makes ovarian cancer cells more susceptible to the cytotoxic effects of an antitumor drug may offer a safer, more effective treatment option for this often deadly form of cancer. The research and results are published in Nucleic Acid Therapeutics. http://medicalxpress.com/news/2013-05-method-sensitize-human-ovarian-cancer.html Cancer Wed, 29 May 2013 15:02:34 EST news289058548 The function of the mitochondria – also defined as "power plants" within the cells – is essential as to whether, and how, some chemotherapeutic agents take effect in tissue. Scientists at the Helmholtz Zentrum München have thus discovered a significant cell characteristic that could possibly predict the success of therapy. Their results will soon be published in the trade magazine The Journal of Pathology. http://medicalxpress.com/news/2013-05-individual-efficacy-chemotherapies.html Cancer Fri, 10 May 2013 08:38:56 EST news287393928 A study led by Robert G. Hawley, Ph.D., professor and chair of the department of anatomy and regenerative biology at the George Washington University (GW) School of Medicine and Health Sciences (SMHS), may help predict which patients with multiple myeloma will respond better to certain treatments. The study, titled "Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1," was published in the American Journal of Hematology . http://medicalxpress.com/news/2013-01-aid-treatment-multiple-myeloma-patients.html Cancer Wed, 23 Jan 2013 15:01:11 EST news278175627 New research demonstrates the efficacy of the first curative treatment for acute promyelocytic leukemia (APL) that does not include chemotherapy, marking an important step toward front-line use of targeted therapies for acute leukemia. http://medicalxpress.com/news/2012-12-atra-arsenic-trioxide-idarubicin-newly.html Cancer Sun, 09 Dec 2012 02:58:55 EST news274244309 An Inserm team in Dijon directed by François Ghiringhelli is to publish an article this week in the Nature Medicine review. The article suggests that two chemotherapy drugs frequently used to treat digestive and breast cancers may encourage the development of tumors by modulating the anti-tumoral immune response. http://medicalxpress.com/news/2012-12-chemotherapy-effectiveness-immune.html Immunology Tue, 04 Dec 2012 13:02:28 EST news273848532 This month, Molecular Pharmaceutics reported promising findings from the Nemours Center for Childhood Cancer Research and the Materials Science and Engineering Department at the University of Delaware, about the potential for nanotechnology to deliver chemotherapeutic agents in a way that attacks cancer cells without harming healthy cells. To date, nanoparticle-based drug delivery approaches have been poorly developed for the treatment of childhood leukemia, which comprises 30% of childhood cancers. In the Nemours study, encapsulated dexamethasone ("dex") delivered to pre-clinical models with leukemia significantly improved quality of life and survival compared to the control receiving the unencapsulated drug. http://medicalxpress.com/news/2012-12-nanotechnology-drug-delivery-treatment-pediatric.html Cancer Tue, 04 Dec 2012 12:06:07 EST news273845157 There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart of the target. http://medicalxpress.com/news/2012-11-cancer-therapy-nanokey-tumors.html Cancer Wed, 14 Nov 2012 11:04:22 EST news272113452 Few available treatment options exist once prostate cancer has spread to other parts of the body and has failed to respond to therapies that involve blocking the male hormone androgen. Patients with advanced, hormone-refractory prostate cancer usually die from the disease after 12 to 18 months, so new therapies are desperately needed. http://medicalxpress.com/news/2012-11-therapy-advanced-prostate-cancer-anti-tumor.html Cancer Wed, 07 Nov 2012 18:26:19 EST news271535169 Blocking the action of a particular protein in our skin could improve the treatment of skin cancers, according to a study published in Oncogene yesterday by Philippe Roux, a researcher at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC). http://medicalxpress.com/news/2012-10-melanoma-resistance-chemotherapy.html Cancer Wed, 31 Oct 2012 17:19:34 EST news270922760 Cancer remains one of the leading causes of death in Europe and the world, and early detection and treatment remains vital in the fight. Researchers in Norway have validated a method of non-invasive imaging that they believe will aid in the identification of aggressive tumours. Their breakthrough provides valuable information about interstitial fluid pressure (IFP) of solid tumours, and their results have been published in Cancer Research. http://medicalxpress.com/news/2012-10-imaging-picture-tumours.html Cancer Fri, 12 Oct 2012 08:25:47 EST news269249138 Researchers validated a method of noninvasive imaging that provides valuable information about interstitial fluid pressure of solid tumors and may aid in the identification of aggressive tumors, according to the results of a study published in Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-10-noninvasive-enables-ifp-potential-biomarker.html Cancer Mon, 01 Oct 2012 02:31:58 EST news268277502 Mayo Clinic researchers have found a way to detect and eliminate potentially troublemaking stem cells to make stem cell therapy safer. Induced Pluripotent Stem cells, also known as iPS cells, are bioengineered from adult tissues to have properties of embryonic stem cells, which have the unlimited capacity to differentiate and grow into any desired types of cells, such as skin, brain, lung and heart cells. However, during the differentiation process, some residual pluripotent or embryonic-like cells may remain and cause them to grow into tumors. http://medicalxpress.com/news/2012-09-weed-problem-stem-cells-therapy.html Medical research Thu, 27 Sep 2012 09:27:57 EST news267956868 (Medical Xpress) -- Expression levels of a DNA repair gene called MGMT have been widely studied across many cancers as a biomarker of response to temozolomide, a chemotherapeutic agent. Now Australian scientists have published findings suggesting MGMT may also play a significant role in tumour progression. http://medicalxpress.com/news/2012-07-pituitary-tumours-biology-cancers.html Cancer Mon, 30 Jul 2012 08:15:26 EST news262854791 Researchers have developed a new genetic screening tool that will aid in the investigation of possible treatments for patients with melanoma and the unique genetic mutations that may accompany the disease, according to data presented at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, held Nov. 12-16, 2011. http://medicalxpress.com/news/2011-11-panel-melanoma-mutations-door-treatment.html Cancer Tue, 15 Nov 2011 16:04:03 EST news240595419 A new strategy that takes advantage of ovarian cancer's reliance on folate appears to give relapse patients extra months of life with few side effects, researchers say. http://medicalxpress.com/news/2011-10-folate-receptors-front-door-ovarian.html Cancer Fri, 28 Oct 2011 11:11:47 EST news239019097 According to new Dutch research featured in the September issue of The Journal of Nuclear Medicine, a peptide receptor radiolabeled therapy (PRRT), [177Lu-DOTA0,Tyr3]Octreotate (177Lu-octreotate) , is effective not only in decreasing tumor size but also in reducing the severity of side effects that often accompany a cancer diagnosis. While many neuroendocrine cancers are incurable, they grow relatively slowly, and life expectancy is relatively long, making quality of life an important factor in treatment. http://medicalxpress.com/news/2011-09-benefits-radionuclide-therapy-neuroendocrine-tumors.html Cancer Tue, 20 Sep 2011 14:27:17 EST news235747604 Scientists may have a way to make the powerful cancer drug cisplatin less toxic to the kidneys and more effective against some cancers. http://medicalxpress.com/news/2011-06-potential-treatment-cancer-drug-kidney.html Cancer Thu, 02 Jun 2011 10:11:44 EST news226228285 Brain cancer therapy may be more effective if the expression of an iron-storing protein is decreased to enhance the action of therapeutic drugs on brain cancer cells, according to Penn State College of Medicine researchers. http://medicalxpress.com/news/2011-06-iron-key-brain-tumor-drug.html Cancer Thu, 02 Jun 2011 10:09:16 EST news226228146