http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. (Medical Xpress)—Scientists at The University of Nottingham say adverse side-effects caused by the anti-parasitic drug quinine in the treatment of malaria could be controlled by what we eat. http://medicalxpress.com/news/2012-09-diet-combat-adverse-side-effects-quinine.html Diseases, Conditions, Syndromes Tue, 11 Sep 2012 06:25:58 EST news266563525 (Medical Xpress) -- Treating metastatic melanoma by combining immunotherapy with a drug that inhibits the cancer-spreading activity of a common gene mutation significantly increased survival times in an animal model, according to a study by researchers at UCLA's Jonsson Comprehensive Cancer Center. http://medicalxpress.com/news/2012-08-combination-therapy-one-two-skin-cancer.html Cancer Thu, 16 Aug 2012 18:20:02 EST news264358967 (Medical Xpress) -- A Johns Hopkins expert in the drug treatment of HIV disease and AIDS is spearheading an international effort to radically shift the manufacturing and prescribing of combination therapies widely credited in the last decade for keeping the disease in check for 8 million of the 34 million infected people worldwide.  http://medicalxpress.com/news/2012-07-front-worldwide-aids-anti-hiv-drugs.html HIV & AIDS Fri, 06 Jul 2012 07:05:04 EST news260777093 A study conducted at Boston University School of Medicine (BUSM) demonstrates an effective combination therapy for breast cancer cells in vitro. The findings, published in the July 2012 issue of Anticancer Research, raise the possibility of using this type of combination therapy for different forms of breast cancer, including those that develop resistance to chemotherapy and other treatments. http://medicalxpress.com/news/2012-07-vitro-potential-combination-therapy-breast.html Cancer Mon, 02 Jul 2012 12:07:10 EST news260449621 For the first time, a study has found that intensive cholesterol therapy involving a combination of drugs for 20 years may be more effective over the long run than taking a single statin medication. http://medicalxpress.com/news/2012-06-intensive-cholesterol-therapy-multiple-drugs.html Medications Mon, 25 Jun 2012 14:10:01 EST news259848384 (Medical Xpress) -- A recent clinical trial testing a combination therapy for basal-like (also known as triple-negative) breast cancer demonstrates that a combination of two drugs with promising preclinical results is not as effective as researchers had hoped. http://medicalxpress.com/news/2012-06-combination-therapy-triple-negative-breast-cancer.html Cancer Wed, 13 Jun 2012 07:16:22 EST news258790575 Inflammatory breast cancer is a very aggressive type of cancer associated with early metastasis and poor survival rates, and the prognosis is even worse for patients with tumors expressing the ErbB2 receptor. The ErbB2-inhibiting drug lapatinib can slow the spread of cancer cells in individuals with advanced breast cancer who have already tried other chemotherapy medications. Treating these patients with a combination of drugs has the potential to improve outcomes compared to treatment with lapatinib alone, but it has not been clear whether the additional benefits outweigh the risks. Now, researchers from Fox Chase Cancer Center and their international collaborators will present information at the 2012 Annual Meeting of the American Society of Clinical Oncology on Saturday, June 2 that will give clinicians the information needed to make that call. http://medicalxpress.com/news/2012-06-combination-treatment-lapatinib-pazopanib-doesnt.html Cancer Fri, 01 Jun 2012 19:31:51 EST news257797903 (HealthDay) -- Updated evidence on hormone replacement therapy for menopausal women presents good news for those at risk of osteoporosis, but a mixed bag of results regarding breast cancer and other chronic diseases. http://medicalxpress.com/news/2012-05-hrt-therapy-fractures-boost.html Medical research Mon, 28 May 2012 17:33:20 EST news257445154 Scientists at Virginia Commonwealth University Massey Cancer Center may be one step closer to developing a new therapy for acute myeloid leukemia (AML) after discovering that the targeted agents obatoclax and sorafenib kill leukemia cells much more effectively when combined than when the drugs are administered individually. http://medicalxpress.com/news/2012-05-scientists-potential-leukemia-treatment.html Cancer Tue, 22 May 2012 18:20:01 EST news256928130 Multiple research projects – including a 2006 study conducted at the University of North Carolina at Chapel Hill – have used DNA microarray analysis to identify several breast cancer subtypes, including luminal A, luminal B, basal-like and HER2-enriched. Simple tests are being developed to help doctors identify these subtypes and to treat their patients in a more biologically-based way. In turn, these tests have made several studies possible that indicate that basal-like, or triple negative breast cancer, is more prevalent in African Americans than their Caucasian counterparts. http://medicalxpress.com/news/2012-05-discovery-combination-therapy-strategy-basal-like.html Cancer Mon, 21 May 2012 11:31:23 EST news256818638 Frank M. Brunkhorst, M.D., of Friedrich-Schiller University, Jena, Germany, and colleagues conducted a study to compare the effect of the antibiotics moxifloxacin and meropenem with the effect of meropenem monotherapy on sepsis-related organ dysfunction. Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The authors hypothesized that maximizing the potential benefit and appropriateness of initial antibiotics by using 2 antibiotics would improve clinical outcomes compared with monotherapy. http://medicalxpress.com/news/2012-05-combination-antibiotic-treatment-result-failure.html Diseases, Conditions, Syndromes Mon, 21 May 2012 11:00:22 EST news256812317 (Medical Xpress) -- University of Florida researchers teamed with colleagues at City of Hope National Medical Center in Duarte, Calif., to devise a new combination therapy that reverses established Type 1 diabetes in mice. http://medicalxpress.com/news/2012-05-dual-strategy-diabetes.html Medical research Thu, 10 May 2012 06:20:38 EST news255849622 Identification of a non-traditional pathway for spiriting a cancer-promoting protein into the cell nucleus points to a possible combination therapy for esophageal cancer and indicates a mechanism of resistance for new drugs that attack the Hedgehog pathway. http://medicalxpress.com/news/2012-03-scientists-link-cancer-promoting-pathways-esophageal.html Cancer Mon, 19 Mar 2012 17:11:15 EST news251395859 Infants with Batten disease, a rare but fatal neurological disorder, appear healthy at birth. But within a few short years, the illness takes a heavy toll, leaving children blind, speechless and paralyzed. Most die by age 5. http://medicalxpress.com/news/2012-03-combination-treatment-mice-fatal-neurological.html Neuroscience Thu, 15 Mar 2012 16:47:48 EST news251048849 A team of 18 researchers at Moffitt Cancer Center in Tampa, Fla., have found that treating high-risk, soft tissue sarcoma patients with a combination of implanted dendritic cells (immune system cells) and fractionated external beam radiation (EBRT) provided more than 50 percent of their trial patients with tumor-specific immune responses lasting from 11 to 42 weeks. http://medicalxpress.com/news/2012-03-sarcoma-tumor-immune-response-combination.html Cancer Thu, 01 Mar 2012 11:29:14 EST news249823745 As researchers work to eliminate malaria worldwide, new strategies are needed to find and treat individuals who have malaria, but show no signs of the disease. The prevalence of asymptomatic or minimally symptomatic malaria can be as high as 35 percent in populations with malaria and these asymptomatic individuals can serve as a reservoir for spreading malaria even in areas where disease transmission has declined. http://medicalxpress.com/news/2012-02-strategy-malaria.html Diseases, Conditions, Syndromes Mon, 06 Feb 2012 16:40:02 EST news247767850 A Henry Ford Hospital study has found that using two types of common asthma medications in combination reduces severe asthma attacks. http://medicalxpress.com/news/2012-02-combined-asthma-medication-therapy-shown.html Diseases, Conditions, Syndromes Mon, 06 Feb 2012 11:14:47 EST news247749278 Adding pertuzumab to a combination of trastuzumab and docetaxel chemotherapy extended progression-free survival by a median of 6.1 months in patients with metastatic HER2-positive breast cancer compared with patients who received the combination therapy with placebo. http://medicalxpress.com/news/2011-12-dual-her2-blockade-significantly-progression-free.html Cancer Thu, 08 Dec 2011 03:53:03 EST news242538772 Glioblastoma is regarded as the most malignant form of brain tumor. In many cases, neurosurgeons are not able to remove such tumors completely because of the risk of destroying too much brain tissue in the process. Moreover, it is often impossible to identify all the fine extensions by which the tumor spreads into surrounding healthy tissue. To at least slow down the growth of tumor cells that have remained in the head, almost all glioblastoma patients are treated by radiotherapy after surgery. http://medicalxpress.com/news/2011-11-treatment-brain-tumors.html Cancer Wed, 23 Nov 2011 10:00:01 EST news241263401 The debate about using menopausal hormone therapies to relieve symptoms in post-menopausal women has been ongoing. Is the combination therapy of estrogen and progestin better or worse than just giving women estrogen alone? In women who still have a uterus (those who have not had a hysterectomy), progestin counteracts the increased risk of uterus cancer when estrogen is given alone, but at the expense of an increase in breast cancer risk compared to estrogen alone. http://medicalxpress.com/news/2011-11-combo-hormone-therapy-breast-cancer.html Cancer Fri, 18 Nov 2011 09:05:05 EST news240829394 (Medical Xpress) -- Post-menopausal women who experience breast tenderness after starting combination hormone therapy have a higher risk of breast cancer than women who don't, a study by researchers with UCLA's Jonsson Comprehensive Cancer Center has shown. One reason for this, they now say, may be that these women's breasts are becoming more dense. http://medicalxpress.com/news/2011-10-breast-tenderness-linked-density.html Cancer Mon, 24 Oct 2011 07:52:05 EST news238661007 The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has stopped one arm of a three arm multi-center, clinical trial studying treatments for the lung-scarring disease idiopathic pulmonary fibrosis (IPF) for safety concerns. The trial found that people with IPF receiving a currently used triple-drug therapy consisting of prednisone, azathioprine, and N-acetylcysteine (NAC) had worse outcomes than those who received placebos, or inactive substances. http://medicalxpress.com/news/2011-10-commonly-drug-regimen-idiopathic-pulmonary.html Diseases, Conditions, Syndromes Fri, 21 Oct 2011 17:24:01 EST news238436620 Post-menopausal women who experience new onset breast tenderness after starting combination hormone therapy may have an increased risk of breast cancer compared to women who don't experience breast tenderness, a study by researchers at UCLA's Jonsson Comprehensive Cancer Center has shown. One reason for this may be that their breasts are becoming more dense. http://medicalxpress.com/news/2011-10-breast-tenderness-women-combo-hormone.html Cancer Fri, 14 Oct 2011 11:10:57 EST news237809442 Patients who have high-risk non-melanoma skin carcinomas of the head and neck may benefit from concomitant radiotherapy and chemotherapy, according to a UNC-led study. Their study is the first to report on multiple patients with these skin carcinomas treated simultaneously with radio-and chemotherapy. http://medicalxpress.com/news/2011-10-combination-therapy-beneficial-neck-skin.html Cancer Tue, 04 Oct 2011 11:04:42 EST news236944966 East Africa is fighting the worst kala azar outbreak in a decade. Collaboration across the region through the Leishmaniasis East Africa Platform (LEAP) has resulted in the development of a new combination therapy (SSG&PM) which is cheaper and nearly halves the length of treatment from a 30 day course of injections to 17 days. East African endemic countries are taking the necessary regulatory measures to use it in their programmes, but experts warn that without international funding or interest in supporting governments in the roll out, too few patients will benefit. http://medicalxpress.com/news/2011-09-treatment-kala-azar-deadly-parasitic.html Diseases, Conditions, Syndromes Fri, 23 Sep 2011 10:20:55 EST news235992031 Researchers are working to discover how genes interact with each other to lead to cancer progression. This research is expected to lead the way toward the discovery of new targeted therapies against breast cancer, according to a study presented at the Second AACR International Conference on Frontiers in Basic Cancer Research, held here Sept. 14-18, 2011. http://medicalxpress.com/news/2011-09-pathways-cancer-identification-therapies.html Cancer Thu, 15 Sep 2011 14:10:42 EST news235314614 Elevated blood cholesterol levels are regarded as a risk factor for heart attacks and other cardiovascular diseases. However, this does not necessarily mean that every cholesterol-lowering drug can also prevent heart attacks. For example, the benefit of the cholesterol-lowering drug ezetimibe is unclear. In particular, proof is lacking that patients have a greater benefit if they take ezetimibe in addition to statins for the prevention of heart attacks. This is the result of the final report published by the German Institute for Quality and Efficiency in Health Care (IQWiG) on 12 September 2011. http://medicalxpress.com/news/2011-09-elevated-cholesterol-benefit-ezetimibe-proven.html Medications Wed, 14 Sep 2011 10:45:09 EST news235215866 A new drug, rilpivirine, can add powerfully to the combination of medications used to control HIV for first-time patients, researchers conclude in Friday's issue of The Lancet. http://medicalxpress.com/news/2011-07-drug-arsenal-aids.html HIV & AIDS Fri, 15 Jul 2011 11:40:06 EST news229948222 According to new research that will be presented Saturday, June 11, at the 20th Anniversary Meeting of the American Academy of Dental Sleep Medicine (AADSM), the apnea-hypopnea index (AHI) in patients with severe obstructive sleep apnea (OSA) was more improved by a combination treatment of a mandibular advancement splint (MAS) and positive airway pressure (PAP) therapy than by continuous positive airway pressure (CPAP) therapy alone. http://medicalxpress.com/news/2011-06-combination-therapy-osa.html Diseases, Conditions, Syndromes Mon, 13 Jun 2011 09:36:30 EST news227176569 (Medical Xpress) -- Researchers at the Duke Cancer Institute and the University of Chicago have found a way to identify the one in four patients with recurring head and neck cancers who are most likely to benefit from a second round of chemotherapy and radiation. http://medicalxpress.com/news/2011-06-criteria-treatment-success-recurring-neck.html Cancer Mon, 13 Jun 2011 08:23:13 EST news227171928