http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. In the first genome-wide association study to focus on warfarin dose requirement in African-Americans, a multi-institutional team of researchers has identified a common genetic variation that can help physicians estimate the correct dose of the widely used blood-thinning drug warfarin. http://medicalxpress.com/news/2013-06-team-genetic-variant-warfarin-dosing.html Medications Tue, 04 Jun 2013 18:30:02 EST news289562531 Cancer research has taken a huge leap forward with scientists now able to identify more than 80 genetic markers found to increase the risk of breast, ovarian and prostate cancer. The COGS international research initiative is believed to be the largest of its kind. http://medicalxpress.com/news/2013-05-massive-cancers-markers.html Genetics Wed, 15 May 2013 09:50:02 EST news287827652 A newly published study of patients with pulmonary fibrosis has discovered multiple genetic variations that should help with future efforts to treat the disease. http://medicalxpress.com/news/2013-04-genetic-variation-contributes-pulmonary-fibrosis.html Genetics Mon, 15 Apr 2013 16:48:54 EST news285263326 About 90 percent of children with two copies of a common genetic variation and who wheezed when they caught a cold early in life went on to develop asthma by age 6, according to a study to be published March 28 by the New England Journal of Medicine. http://medicalxpress.com/news/2013-03-childhood-asthma-tied-combination-genes.html Immunology Wed, 27 Mar 2013 17:00:07 EST news283618892 (Medical Xpress)—A multinational research project led by the Universities of Dundee and Glasgow has identified a genetic determinant of hypertension (or high blood pressure), which could inform treatment of the condition for thousands of patients. http://medicalxpress.com/news/2012-11-genetic-hypertension.html Cardiology Thu, 22 Nov 2012 09:20:01 EST news272795207 Focusing on fine features in order to see "the big picture" seems almost counterintuitive, but that is exactly what is happening in the field of genomics. Researchers are sequencing human genomes, cataloging the variation in people's genetic code – the As, Ts, Gs, and Cs of human DNA that serve as each individual's biological blueprint – to get a broader view of human health, a deeper knowledge of human genetic history, and a clearer understanding of why some people develop certain diseases while others do not. http://medicalxpress.com/news/2012-11-genomes.html Genetics Fri, 16 Nov 2012 06:48:59 EST news272270922 Tyrosine kinase inhibitors (TKIs) kill cancerous cells by inducing programmed cell death. They are of enormous therapeutic benefit to patients with chronic myeloid leukemia (CML) and certain types of lung cancer, but their effectiveness may vary from individual to individual. Previous studies have estimated that one in five patients finds TKIs to be ineffective. An international team of researchers including Yijun Ruan and Axel Hillmer at the A*STAR Genome Institute of Singapore, Sin Tiong Ong and King Pan Ng at the Duke-National University of Singapore Graduate Medical School, Charles Chuah at the Department of Haematology, Singapore General Hospital and Darren Wan-Teck Lim at the National Cancer Centre has now identified a common genetic variation linked with resistance to TKIs. http://medicalxpress.com/news/2012-08-genetic-variation-common-east-asian.html Genetics Thu, 02 Aug 2012 08:19:37 EST news263112686 Although the U.S. Food and Drug Administration (FDA) has recommended that a certain type of genetic testing (for the genotype CYP2C19) be considered before prescribing the drug clopidogrel to identify individuals who may be less responsive to the medication, a review and analysis of previous studies did not find an overall significant association between the CYP2C19 genotype and cardiovascular events, according to a study in the December 28 issue of JAMA. http://medicalxpress.com/news/2011-12-analysis-genetic-anti-clotting-drug.html Genetics Tue, 27 Dec 2011 16:00:01 EST news244196798 Asthma patients could clearly benefit from personalized medicine, a new study suggests. However, the new discovery of a key gene, while exciting, does not mean that day is here quite yet. http://medicalxpress.com/news/2011-10-asthma-treatment-personalized-medicine.html Diseases, Conditions, Syndromes Wed, 05 Oct 2011 04:51:09 EST news237009055