Medical Xpress: PHYSorg news tagged with: dehydrogenase http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Study demonstrates effects of mutant IDH1 and IDH2 inhibitors in primary tumor models Agios Pharmaceuticals announced today the publication of two articles in the journal Science by Agios scientists and their collaborators demonstrating the effects of the company's small molecule isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) mutant specific inhibitors in primary human tumor models. These data add to a growing body of scientific research demonstrating the significant promise of targeting mutant IDH1 and IDH2 enzymes as novel approaches to treating cancer. http://medicalxpress.com/news/2013-04-effects-mutant-idh1-idh2-inhibitors.html Cancer Thu, 04 Apr 2013 14:00:01 EST news284301154 Pesticides and Parkinson's: Researchers uncover further proof of a link (Medical Xpress)—For several years, neurologists at UCLA have been building a case that a link exists between pesticides and Parkinson's disease. To date, paraquat, maneb and ziram—common chemicals sprayed in California's Central Valley and elsewhere—have been tied to increases in the disease, not only among farmworkers but in individuals who simply lived or worked near fields and likely inhaled drifting particles. http://medicalxpress.com/news/2013-01-pesticides-parkinson-uncover-proof-link.html Parkinson's & Movement disorders Fri, 04 Jan 2013 06:45:05 EST news276504277 Common enzyme deficiency may hinder plans to eradicate malaria In malaria-endemic countries, 350 million people are predicted to be deficient in an enzyme that means they can suffer severe complications from taking primaquine, a key drug for treating relapsing malaria, according to a study funded by the Wellcome Trust and published in this week's PLOS Medicine. http://medicalxpress.com/news/2012-11-common-enzyme-deficiency-hinder-eradicate.html Diseases, Conditions, Syndromes Tue, 13 Nov 2012 17:00:07 EST news272046676 Study shows vitamin E may decrease cancer risk in Cowden syndrome patients Cleveland Clinic researchers have discovered that vitamin E may prevent cancer in patients with an under-recognized genetic disorder. http://medicalxpress.com/news/2012-09-vitamin-decrease-cancer-cowden-syndrome.html Cancer Mon, 17 Sep 2012 16:12:03 EST news267117109 Noninvasive imaging can detect mutations within a brain tumor Researchers at Winship Cancer Institute have developed a technique for detecting an "oncometabolite", a chemical produced by some brain tumors' warped metabolism, via non-invasive imaging. http://medicalxpress.com/news/2012-03-noninvasive-imaging-mutations-brain-tumor.html Cancer Thu, 22 Mar 2012 10:50:27 EST news251632173 Three studies find IDH enzyme mutations may alter activity leading to growth of cancer tumors (Medical Xpress) -- Three research teams have published papers in Nature, that together offer evidence suggesting that isocitrate dehydrogenase (IDH) enzyme mutations may play a role in altering activity that could have an impact on whether or not cancerous tumors begin to grow. http://medicalxpress.com/news/2012-02-idh-enzyme-mutations-growth-cancer.html Medical research Thu, 16 Feb 2012 10:28:04 EST news248610418 The aldehyde dehydrogenase-2 polymorphism affects alcohol dependence differently by gender Researchers know that gender differences exist in the prevalence, characteristics, and course of alcohol dependence (AD). Polymorphisms of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) are strong genetic determinants of AD. A new study of gender differences in the effects of these polymorphisms on the development of AD has found that inactive ALDH2 can accelerate the development of AD in women. http://medicalxpress.com/news/2011-08-aldehyde-dehydrogenase-polymorphism-affects-alcohol.html Other Mon, 15 Aug 2011 16:00:06 EST news232642090