http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Multi-peptide vaccination therapy combined with the low-dose steroid drug dexamethasone shows promise in treating chemotherapy-naive castration resistant prostate cancer (CRPC) patients. http://medicalxpress.com/news/2013-03-japanese-p2-potential-combined-vaccine.html Cancer Fri, 15 Mar 2013 03:00:03 EST news282499148 (HealthDay)—Corticorelin acetate (CrA) administration to patients with peritumoral brain edema (PBE) allows the reduction of steroid doses and is associated with reduced incidence and severity of steroid-induced myopathy and other steroid-related adverse effects, according to research published online Feb. 4 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2013-02-corticorelin-acetate-steroid-sparing-effect-brain.html Cancer Wed, 06 Feb 2013 15:00:01 EST news279384191 A new oral agent under review by the U.S. Food and Drug Administration (FDA) is safe and effective in treating relapsed and treatment-resistant multiple myeloma, according to a multicenter, Phase II study presented by Mount Sinai School of Medicine researchers at the American Society of Hematology (ASH) Annual Meeting. The meeting is taking place December 8-11, 2012 in Atlanta. http://medicalxpress.com/news/2012-12-multiple-myeloma-drug-people-advanced.html Cancer Mon, 10 Dec 2012 11:50:11 EST news274359619 This month, Molecular Pharmaceutics reported promising findings from the Nemours Center for Childhood Cancer Research and the Materials Science and Engineering Department at the University of Delaware, about the potential for nanotechnology to deliver chemotherapeutic agents in a way that attacks cancer cells without harming healthy cells. To date, nanoparticle-based drug delivery approaches have been poorly developed for the treatment of childhood leukemia, which comprises 30% of childhood cancers. In the Nemours study, encapsulated dexamethasone ("dex") delivered to pre-clinical models with leukemia significantly improved quality of life and survival compared to the control receiving the unencapsulated drug. http://medicalxpress.com/news/2012-12-nanotechnology-drug-delivery-treatment-pediatric.html Cancer Tue, 04 Dec 2012 12:06:07 EST news273845157 Using tiny spheres filled with an anesthetic derived from a shellfish toxin, researchers at Boston Children's Hospital and the Massachusetts Institute of Technology have developed a way to delay the rise of neuropathic pain, a chronic form of pain that arises from flawed signals transmitted by damaged nerves. http://medicalxpress.com/news/2012-10-block-neuropathic-pain.html Medical research Tue, 09 Oct 2012 10:52:28 EST news268998715 Tonsillectomy is exceedingly common, with a reported increase in tonsillectomy rates in children younger than 15 years from 287,000 to 530,000 per year over the past decade. Although safe, adenotonsillectomy can result in significant complications, such as aspiration and bleeding. Complications are infrequent, but because tonsillectomy is so common, the absolute number of children experiencing tonsillectomy complications is formidable. http://medicalxpress.com/news/2012-09-pre-op-steroids-nausea-significantly-post-op.html Diseases, Conditions, Syndromes Tue, 25 Sep 2012 16:00:03 EST news267807366 (HealthDay) -- Adding dexamethasone to prochlorperazine on days two and three, following palonosetron and dexamethasone on day one, reduces delayed nausea (DN) in patients receiving chemotherapy containing a platinum-based drug or an anthracycline, according to research published online Aug. 20 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-08-prolonged-dexamethasone-nausea-chemo.html Cancer Wed, 22 Aug 2012 16:50:01 EST news264870982 (Medical Xpress) -- A new paper just published in the Journal of Bioethical Inquiry uses extensive Freedom of Information Act findings to detail an extremely troubling off-label medical intervention employed in the U.S. on pregnant women to intentionally engineer the development of their fetuses for sex normalization purposes. http://medicalxpress.com/news/2012-08-dangerous-fetal.html Other Fri, 03 Aug 2012 06:48:52 EST news263195324 (HealthDay) -- For patients with newly diagnosed multiple myeloma (MM), induction treatment with a combination of bortezomib, doxorubicin, and dexamethasone (PAD) followed by bortezomib maintenance therapy improves complete response (CR), progression-free survival (PFS), and overall survival (OS) rates, according to a study published online July 16 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-07-bortezomib-ups-response-survival-multiple.html Cancer Mon, 23 Jul 2012 19:40:01 EST news262286111 Cabazitaxel (trade name: Jevtana) has been approved since March 2011 in men with metastatic prostate cancer who no longer respond to conventional therapy with hormone blockers and have already been pre-treated with the cytostatic drug docetaxel. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether cabazitaxel offers an added benefit compared with the present standard therapy. http://medicalxpress.com/news/2012-05-cabazitaxel-advantage-patients.html Cancer Tue, 29 May 2012 13:07:31 EST news257515625 (HealthDay) -- For patients with relapsed or refractory multiple myeloma, combination treatment with elotuzumab, lenalidomide, and low-dose dexamethasone is generally well tolerated, with encouraging response rates, according to a study published online April 30 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-05-chemo-combination-multiple-myeloma.html Cancer Wed, 02 May 2012 15:30:01 EST news255188297 Two studies published today in Blood, the Journal of the American Society of Hematology (ASH), demonstrate preliminary success of an effective multiple myeloma (MM) regimen in patients with AL amyloidosis, a rare and devastating blood disease that results in deposition of damaging abnormal protein in critical organs of the body, including the kidneys, heart, liver, and intestines, and shares some characteristics with MM. http://medicalxpress.com/news/2012-02-powerful-myeloma-treatment-regimen-al.html Cancer Mon, 13 Feb 2012 13:28:09 EST news248362040 Abiraterone (trade name: Zytiga) has been approved since September 2011 for men with metastatic prostate cancer that is no longer responsive to hormone therapy and progresses further during or after therapy with the cytostatic drug docetaxel. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether abiraterone offers an added benefit compared with the present standard therapy. http://medicalxpress.com/news/2012-01-abiraterone-indication-considerable-added-benefit.html Medications Fri, 06 Jan 2012 09:46:34 EST news245065586 (Medical Xpress) -- A three-drug combination treatment for the blood cancer multiple myeloma compares favorably to the best established therapy for newly diagnosed patients, according to a multi-center study led by Andrzej Jakubowiak, MD, PhD, professor of medicine and director of the multiple myeloma program at the University of Chicago Medical Center. http://medicalxpress.com/news/2011-12-drug-combination-highly-effective-newly.html Cancer Thu, 08 Dec 2011 06:00:01 EST news242545705 Premature infants exposed after birth to drugs known as glucocorticoids are at increased risk for having impaired growth of the cerebellum, according to findings from a new UCSF-led study. The cerebellum is a region of the brain associated with balance, motor learning, language and behavior. http://medicalxpress.com/news/2011-10-pre-term-babies-exposure-steroids-impaired.html Neuroscience Wed, 19 Oct 2011 14:00:05 EST news238248969 Overexposure to stress hormones in the womb can program the potential for adverse health effects in those children and the next generation, but effects vary depending on whether the mother or father transmits them, a new animal study suggests. http://medicalxpress.com/news/2011-06-fetal-disease-parental-gender.html Health Sat, 04 Jun 2011 14:20:01 EST news226414098