http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A significant breakthrough has been made by scientists at The University of Manchester towards developing an effective treatment for neurodegenerative diseases such as Huntington's, Alzheimer's and Parkinson's. http://medicalxpress.com/news/2013-04-team-breakthrough-neurodegenerative-disease-treatments.html Medical research Wed, 10 Apr 2013 13:00:02 EST news284817534 Research for diabetes is far more focused on drug therapies than preventive measures, and tends to exclude children and older people who have much to gain from better disease management, according to a Duke Medicine study. http://medicalxpress.com/news/2013-04-treatments-dominate-diabetes.html Diabetes Fri, 05 Apr 2013 18:10:01 EST news284401446 Researchers at Mayo Clinic Cancer Center have developed new guidelines to treat recently diagnosed multiple myeloma patients who are not participating in clinical trials. The guidelines give physicians practical, easy to follow recommendations for providing initial therapy, stem cell transplant and maintenance therapy. The guidelines are published in the current issue of the journal Mayo Clinic Proceedings and represent a consensus opinion of hematologists at Mayo Clinic Cancer Center sites in Minnesota, Florida and Arizona. http://medicalxpress.com/news/2013-04-multiple-myeloma-treatment-guidelines-personalize.html Cancer Mon, 01 Apr 2013 12:23:08 EST news284037777 (Medical Xpress)—Researchers from Plymouth University Peninsula Schools of Medicine and Dentistry are part of an international team which has for the first time identified the role of a tumour suppressor in peripheral neuropathy in those suffering multiple tumours of the brain and nervous system. http://medicalxpress.com/news/2013-03-brain-tumours-peripheral-neuropathy.html Neuroscience Tue, 05 Mar 2013 07:20:06 EST news281688839 Researchers at Wake Forest Baptist Medical Center and colleagues have identified a special population of adult stem cells in bone marrow that have the natural ability to migrate to the intestine and produce intestinal cells, suggesting their potential to restore healthy tissue in patients with inflammatory bowel disease (IBD). http://medicalxpress.com/news/2013-02-cell-therapy-bowel-disease.html Medical research Thu, 28 Feb 2013 04:14:29 EST news281247258 Researchers used induced pluripotent stem cells (iPSCs) derived from a young patient with Long QT syndrome (LQTS), a congenital heart disorder, to determine a course of treatment that helped manage the patient's life-threatening arrhythmias. The results, which appear in The Journal of General Physiology, could lead to improved treatments for LQTS and other channelopathies, diseases caused by disturbed ion channel function. http://medicalxpress.com/news/2013-01-ipscs-optimal-treatment-life-threatening-arrhythmias.html Cardiology Fri, 11 Jan 2013 12:18:05 EST news277129079 (Medical Xpress)—Research led by Queen Mary, University of London, has opened up the possibility that drug therapies may one day be able to restore the integrity of the blood-brain barrier, potentially slowing or even reversing the progression of diseases like multiple sclerosis (MS). The study, funded by the Wellcome Trust, is published in Proceedings of the National Academy of Sciences. http://medicalxpress.com/news/2013-01-possibility-therapies-blood-brain-barrier.html Medical research Wed, 02 Jan 2013 10:55:59 EST news276346551 Literally hundreds of clinical trials, including some that have gained widespread attention, have been done on the possible benefits of omega-3 fatty acids for the prevention of heart disease – producing conflicting results, varied claims, and frustrated consumers unsure what to believe. http://medicalxpress.com/news/2012-11-analysis-conflicting-fish-oil-omega-.html Health Wed, 28 Nov 2012 13:37:02 EST news273332211 (Medical Xpress)—A research team made up of a group of private practitioners and medical experts has conducted a follow-up study of a trial of 3,4-methylenedioxymethamphetamine (MDMA) use in therapy sessions to treat Post Traumatic Stress Disorder (PTSD). In describing their results in their paper published in the Journal of Psychopharmacology, the team says that 17 of 20 patients who participated in the original study reported positive results long term. http://medicalxpress.com/news/2012-11-follow-up-benefit-mdma-people-ptsd.html Psychology & Psychiatry Wed, 21 Nov 2012 09:40:01 EST news272711659 A study in The Journal of Cell Biology shows how a transcription factor called STAT3 remains in the axon of nerve cells to help prevent neurodegeneration. The findings could pave the way for future drug therapies to slow nerve damage in patients with neurodegenerative diseases. http://medicalxpress.com/news/2012-10-stay-at-home-transcription-factor-neurodegeneration.html Medical research Mon, 29 Oct 2012 13:10:20 EST news270734992 After surgeons removed the tumor from her breast last November, Karen Hajiaskari, of Hamburg, N.Y., was deemed cancer-free. But for the next five years she will take a drug called tamoxifen, a medication that's commonly used to prevent a breast cancer recurrence. http://medicalxpress.com/news/2012-10-additional-medicines-recurrence-issues.html Cancer Sun, 07 Oct 2012 15:30:01 EST news268839720 The inflammatory response is a double-edged sword—it enables the body to mount a vigorous defense against infection, but can also inflict serious physiological damage if allowed to rampage uncontrolled. Patients experience the worst of both worlds when an infection gives way to sepsis. They undergo an initial strong inflammatory response that subsequently gives way to immunosuppression, wherein immune cells no longer respond to toxic molecules produced by bacteria. http://medicalxpress.com/news/2012-09-inappropriate-immune-pathway-infection-body.html Immunology Wed, 26 Sep 2012 11:00:02 EST news267875244 New research shows that a special population of stem cells found in cord blood has the innate ability to migrate to the intestine and contribute to the cell population there, suggesting the cells' potential to treat inflammatory bowel disease (IBD). http://medicalxpress.com/news/2012-09-cell-therapy-bowel-disease.html Diseases, Conditions, Syndromes Wed, 19 Sep 2012 15:53:24 EST news267288796 Researchers at the Georgia Health Sciences University Cancer Center have identified a gene that disrupts the inflammatory process implicated in liver cancer. http://medicalxpress.com/news/2012-08-inflammation-cancers.html Cancer Wed, 22 Aug 2012 16:06:58 EST news264870392 A laboratory study led by UNC medical oncologist Stergios Moschos, MD, demonstrates how a new targeted drug, Elesclomol, blocks oxidative phosphorylation, which appears to play essential role in melanoma that has not been well-understood. Elesclomol (Synta Pharmaceuticals, Lexington, MA) was previously shown to have clinical benefit only in patients with normal serum lactate dehydrogenase (LDH), a laboratory test routinely used to assess activity of disease. http://medicalxpress.com/news/2012-08-reveals-molecular-melanoma-treatment.html Cancer Fri, 17 Aug 2012 23:17:06 EST news264464196 A new study shows that taking part in a stress management program may help people with multiple sclerosis (MS) prevent new disease activity. The study is published in the July 11, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology. http://medicalxpress.com/news/2012-07-stress-disease-multiple-sclerosis.html Neuroscience Wed, 11 Jul 2012 16:00:04 EST news261240827 Researchers in the biological sciences department in the Faculty of Science at the University of Calgary have revealed how white blood cells move to infection or inflammation in the body; findings which could help lead to developing drug therapies for immune system disorders. The research is published this month in the Journal of Biological Chemistry. http://medicalxpress.com/news/2012-07-closer-proteins-immune.html Immunology Tue, 03 Jul 2012 10:25:43 EST news260529938 In the realm of deadly and disabling diseases, conditions such as cancer and Alzheimer's seem to attract the most media attention. But there are others that take a similarly high toll, and rheumatoid arthritis is one of them, Mayo Clinic researchers say. It is a common cause of disability: 1 of every 5 rheumatoid arthritis patients is unable to work two years after diagnosis, and within five years, that rises to one-third. Life expectancy drops by up to five years, they write in the July issue of Mayo Clinic Proceedings in an article taking stock of current diagnosis and treatment approaches. http://medicalxpress.com/news/2012-07-rheumatoid-arthritis-high-toll-unemployment.html Arthritis & Rheumatism Mon, 02 Jul 2012 04:30:01 EST news260420969 (Medical Xpress) -- Phosphorylation is one of the most important and ubiquitous cell regulatory events. EU-funded researchers assessed the dynamic events of intracellular phosphorylation in two model systems with important implications for targeted drug therapies for cancer and inflammatory responses. http://medicalxpress.com/news/2012-05-real-time-cellular-events.html Cancer Wed, 02 May 2012 05:59:06 EST news255157135 The World Health Organisation heralded major gains Tuesday in the fight against malaria, one of the developing world's biggest killers, but warned universal access to treatment remains elusive. http://medicalxpress.com/news/2012-04-hails-big-gains-anti-malaria.html Diseases, Conditions, Syndromes Tue, 24 Apr 2012 10:48:41 EST news254483311 Cedars-Sinai researchers have determined that two prevalent drug therapies – rifaximin and lubiprostone – offer some of the best options for treating irritable bowel syndrome, a widespread disorder that affects up to one in five Americans. The findings, based on an analysis of more than two dozen large-scale clinical trials, are contained in a peer-reviewed study published online by The American Journal of Medicine and set to appear in the publication's April print edition. http://medicalxpress.com/news/2012-03-drugs-fewest-side-effects-bowel-syndrome.html Diseases, Conditions, Syndromes Mon, 26 Mar 2012 05:00:39 EST news251956826 Researchers from the Hotchkiss Brain Institute (HBI) and the Snyder Institute for Chronic Diseases at the University of Calgary's Faculty of Medicine have discovered a pathway that may contribute to the symptoms related to Crohn's disease and ulcerative colitis, collectively known as Inflammatory Bowel Disease (IBD). This research is a major milestone in developing future drug therapies for those living with these debilitating disorders. http://medicalxpress.com/news/2012-03-crohn-disease.html Inflammatory disorders Wed, 21 Mar 2012 09:22:39 EST news251540547 Cedars-Sinai researchers have unlocked the mystery of how an inflammatory molecule is produced in the body, a discovery they say could lead to advances in the treatment of rheumatoid arthritis, Type 2 diabetes and numerous other chronic diseases that affect tens of millions of people. http://medicalxpress.com/news/2012-03-mechanism-cells-inflammatory-diseases.html Immunology Mon, 12 Mar 2012 10:05:35 EST news250765521 Alternative therapies for dementia patients need to be researched and applied more consistently if they are to help care organisations improve the well-being of patients and reduce the number of antipsychotic drugs prescribed. http://medicalxpress.com/news/2012-02-paves-drug-based-dementia-treatments-behaviors.html Diseases, Conditions, Syndromes Wed, 15 Feb 2012 04:13:20 EST news248501557 A recent discovery by Van Andel Research Institute (VARI) scientists enables the prediction of patient sensitivity to proposed drug therapies for glioblastoma – the most common and most aggressive malignant brain tumor in humans. http://medicalxpress.com/news/2012-02-discovery-patient-sensitivity-important-drug.html Cancer Mon, 06 Feb 2012 16:06:48 EST news247766704 (Medical Xpress) -- A team of researchers at the Johns Hopkins Bloomberg School of Public Health recently discovered a new protein that enables HIV to destroy human cells. The finding provides scientists with a critical glimpse into the complex interactions between HIV proteins and human proteins, a discovery that could potentially lead to new HIV drug therapies. The study was published in the January 19, 2012 issue of Nature. http://medicalxpress.com/news/2012-01-protein-discovery-hiv-drugs.html HIV & AIDS Fri, 27 Jan 2012 08:37:55 EST news246875859 Following a major Northwestern Medicine breakthrough that identified a common converging point for all forms of amyotrophic lateral sclerosis (ALS and Lou Gehrig's disease), a new finding from the same scientists further broadens the understanding of why cells in the brain and spinal cord degenerate in the fatal disease. http://medicalxpress.com/news/2011-11-bad-gene-linked-cell-buildup.html Genetics Mon, 21 Nov 2011 16:20:19 EST news241114788 The influenza virus remains a worldwide threat to humans, causing an average of 36,000 deaths and 200,000 hospitalizations each year in the United States alone. As health care professionals prepare for another flu season, a University of Missouri scientist is studying how two enzymes could be used to stop the virus in its tracks. http://medicalxpress.com/news/2011-11-mu-scientist-eyeing-enzymes-flu.html Medical research Thu, 17 Nov 2011 10:21:38 EST news240747681 A new discovery by Californian scientists may lead to a pharmaceutical breakthrough for a wide range of illnesses that involve the hydration of cells that line the inner surfaces of our body's organs and tissues. In a new report appearing in the FASEB Journal, the researchers describe how they used high-throughput screening to identify small-molecule drug candidates which help cells bypass defective channels that normally move salt and water through cell membranes. These drug candidates work by activating an alternative chloride channel called "TMEM16A" that might be effective in treating conditions such as cystic fibrosis, dry eye and dry mouth diseases and slow-transit constipation. http://medicalxpress.com/news/2011-11-scientists-drug-candidates-cystic-fibrosis.html Medications Tue, 01 Nov 2011 10:16:20 EST news239361372 Researchers at Rutgers and UMDNJ-Robert Wood Johnson Medical School have determined the structure of a protein that is the first line of defense in fighting viral infections including influenza, hepatitis C, West Nile, rabies, and measles. http://medicalxpress.com/news/2011-09-unprecedented-insight-viral-infections.html Medical research Thu, 29 Sep 2011 16:46:30 EST news236533554