http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Four proteins involved in translation, the final step of general protein production, are associated with poor prognosis in hormone-receptor-positive breast cancer when they are dysregulated, researchers reported at the AACR Annual Meeting 2012. http://medicalxpress.com/news/2012-04-pi3kmtor-pathway-proteins-tied-poor.html Cancer Sun, 01 Apr 2012 12:32:10 EST news252502306 In two new studies featured in the February issue of the Journal of Nuclear Medicine, researchers are revealing how molecular imaging can be used to solve mysteries about difficult cases of breast cancer. One article focuses on an imaging agent that targets estrogen receptors in estrogen receptor–positive breast cancer patients with formerly inconclusive assessments, and the second highlights a different imaging agent's ability to help predict the prognosis for patients undergoing chemotherapy for a very aggressive type of breast cancer. http://medicalxpress.com/news/2012-02-pet-techniques-accurate-diagnosis-prognosis.html Cancer Mon, 06 Feb 2012 16:25:14 EST news247767908 (Medical Xpress) -- An international team of researchers has identified three new genetic loci associated with an increased susceptibility to breast cancer. As described in their paper published in Nature Genetics, the three new loci will be added to the previous 22 that have been previously found and appear to be associated with mammary gland and bone growth and estrogen receptor signaling. http://medicalxpress.com/news/2012-01-genetic-links-breast-cancer.html Genetics Mon, 23 Jan 2012 14:20:04 EST news246548659 Men are four times more likely to develop liver cancer compared to women, a difference attributed to the sex hormones androgen and estrogen. Although this gender difference has been known for a long time, the molecular mechanisms by which estrogens prevent -- and androgens promote -- liver cancer remain unclear. http://medicalxpress.com/news/2012-01-gender-differences-liver-cancer-small.html Cancer Thu, 19 Jan 2012 12:56:30 EST news246200182 Daily doses of a soy germ-based nutritional supplement containing S-equol significantly improved menopausal symptoms, including significantly reducing hot flash frequency after 12 weeks according to a placebo-controlled study in postmenopausal Japanese women published in the peer-reviewed Journal of Women's Health. http://medicalxpress.com/news/2012-01-fermented-soy-ingredient-s-equol-significantly.html Health Wed, 04 Jan 2012 15:16:55 EST news244912607 Researchers have proven the continuing effectiveness of treating patients with estrogen receptor-positive premenopausal breast cancer with adjuvant zoledronic acid in addition to adjuvant endocrine treatment including ovarian function suppression. http://medicalxpress.com/news/2011-12-zoledronic-acid-long-term-benefit-survivorship.html Cancer Wed, 07 Dec 2011 10:50:02 EST news242476739 The risk of breast cancer is increased by genetic and lifestyle factors such as the inherited BRCA2 gene, age of having first child, or use of hormone replacement therapy (HRT). New research published in BioMed Central's open access journal BMC Cancer looked at the relationship between women with breast cancer and diagnosis of cancer in their parents. The results showed that the chances of women with lobular breast cancer having a father with cancer (especially prostate cancer) was almost twice as likely as women with other forms of breast cancer. http://medicalxpress.com/news/2011-11-breast-cancer-linked-paternal.html Cancer Mon, 28 Nov 2011 10:47:33 EST news241699585 The presence of a new pioneer factor, known as PBX1, can guide the response to estrogen in breast cancer cells according to researchers at Dartmouth-Hitchcock Norris Cotton Cancer Center in results published on November 17 in the open-access journal PLoS Genetics. This research reveals that PBX1 alone can determine the risk of the spread of cancer in patients with estrogen receptor alpha (ERα)-positive breast cancer, which accounts for about two-thirds of all breast cancers diagnosed in North America. http://medicalxpress.com/news/2011-11-pbx1-factor-underlying-breast-cancer.html Genetics Thu, 17 Nov 2011 17:43:51 EST news240774225 In dozens of experiments in mice and in human cancer cells, a team of Johns Hopkins scientists has closely tied production of a cancer-causing protein called TWIST to the development of estrogen resistance in women with breast cancer. Because estrogen fuels much breast cancer growth, such resistance — in which cancers go from estrogen positive to estrogen negative status — can sabotage anticancer drugs that work to block estrogen and prevent disease recurrence after surgery. Estrogen resistance develops in over half of women taking estrogen-blocking medications, such as tamoxifen, and exists from the start in many other women. http://medicalxpress.com/news/2011-11-cancer-causing-protein-strongly-tied-hormone.html Cancer Wed, 16 Nov 2011 07:04:18 EST news240649425 Researchers at the University of Houston (UH) are recommending a new strategy for developing drugs to treat cancer, multiple sclerosis, Alzheimer's and cardiovascular diseases. http://medicalxpress.com/news/2011-10-drug-strategies-alzheimer-multiple-sclerosis.html Alzheimer's disease & dementia Thu, 20 Oct 2011 16:46:02 EST news238347944 A recent UT Southwestern Medical Center study found that estrogen regulates energy expenditure, appetite and body weight, while insufficient estrogen receptors in specific parts of the brain may lead to obesity. http://medicalxpress.com/news/2011-10-estrogen-brain-weight.html Medical research Thu, 20 Oct 2011 02:50:01 EST news238296281 A protein in the nucleus of breast cancer cells that plays a role in fueling the growth of aggressive tumors may be a good target for new drugs, reports a research team at the Duke Cancer Institute. http://medicalxpress.com/news/2011-10-protein-fuels-lethal-breast-cancer.html Cancer Mon, 17 Oct 2011 12:49:32 EST news238074555 UCLA researchers have found that the hormone estrogen may help reverse advanced pulmonary hypertension, a rare and serious condition that affects 2 to 3 million individuals in the U.S., mostly women, and can lead to heart failure. http://medicalxpress.com/news/2011-09-estrogen-treatment-reverse-severe-pulmonary.html Diseases, Conditions, Syndromes Thu, 15 Sep 2011 13:07:13 EST news235310805 UCLA researchers demonstrated that loss of a key protein that regulates estrogen and immune activity in the body could lead to aspects of metabolic syndrome, a combination of conditions that can cause Type 2 diabetes, atherosclerosis and cancer. Called estrogen receptor alpha, this protein is critical in regulating immune system activity such as helping cells suppress inflammation and gobble-up debris. http://medicalxpress.com/news/2011-09-loss-key-estrogen-metabolic-syndrome.html Diseases, Conditions, Syndromes Tue, 06 Sep 2011 14:32:23 EST news234538333 University of Houston (UH) researchers have their sights set on developing possible treatments for breast and colon cancer. http://medicalxpress.com/news/2011-08-uh-explore-treatments-breast-colon.html Cancer Mon, 22 Aug 2011 16:46:26 EST news233250306 For the first time, researchers at Seattle Cancer Care Alliance have demonstrated the feasibility of using serial positron emission tomography (PET) scans, using a special estrogen-containing isotope, to confirm the relative effectiveness of estrogen-blocking and estrogen-depleting therapy in patients with metastatic breast cancer. The results of the research are published online in Clinical Cancer Research. http://medicalxpress.com/news/2011-08-pet-scans-effectiveness-estrogen-blocking-drugs.html Cancer Thu, 18 Aug 2011 10:46:17 EST news232883156 Could some women who naturally produce excess aromatase in their breasts have an increased risk of developing breast cancer? Results of a new animal study suggests that may be the case, say researchers at Georgetown Lombardi Comprehensive Cancer Center, a part of Georgetown University Medical Center. http://medicalxpress.com/news/2011-08-higher-estrogen-production-breast-confer.html Cancer Fri, 12 Aug 2011 12:34:07 EST news232371231 Taking a leukemia chemotherapy drug may help breast cancer patients who don't respond to tamoxifen overcome resistance to the widely-used drug, new research from the Kimmel Cancer Center at Jefferson suggests. http://medicalxpress.com/news/2011-08-leukemia-drug-reverses-tamoxifen-resistance-breast.html Cancer Mon, 01 Aug 2011 12:30:06 EST news231417656 Using a new in vivo screening system, Whitehead Institute researchers have identified a protein in the serine biosynthesis pathway that is essential in estrogen receptor (ER)-negative breast cancer—a notoriously difficult disease to treat associated with low five-year survival rates. http://medicalxpress.com/news/2011-07-key-metabolic-pathway-implicated-intractable.html Cancer Mon, 18 Jul 2011 16:52:22 EST news230226730 A team of Yale Cancer Center researchers has confirmed that between 10-20% of breast cancers classified as Estrogen Receptor (ER) negative are really positive. Understanding when and why breast cancers may be misclassified has important implications for treatment and outcomes for women diagnosed with breast cancer. Its findings are published online in the June 28 Journal of Clinical Oncology. http://medicalxpress.com/news/2011-06-false-negative-breast-cancer-wrong.html Cancer Mon, 27 Jun 2011 16:00:33 EST news228393756 Women with a healthy body weight before and after diagnosis of breast cancer are more likely to survive the disease long term, a new study finds. http://medicalxpress.com/news/2011-06-obesity-breast-cancer-survivors-dying.html Cancer Sat, 04 Jun 2011 14:50:01 EST news226414491 Patterns of radiation usage in breast conserving therapy for women 70 years and older with stage I breast cancer are changing: more women are opting for radioactive implants and those with estrogen positive tumors are opting out of radiation therapy, according to an abstract being presented at the American Society of Clinical Oncology annual meeting in Chicago by Thomas Jefferson University Hospital researchers on Saturday, June 4. The abstract (#6094) received an ASCO Merit Award. http://medicalxpress.com/news/2011-06-emerging-trends-therapy-women-early.html Cancer Thu, 02 Jun 2011 17:26:54 EST news226254381 Cancer researchers at the Kimmel Cancer Center at Jefferson and an international team of collaborators have discovered a biomarker in breast cancer that may help identify which women will respond to anti-estrogen therapy. http://medicalxpress.com/news/2011-05-marker-breast-cancer-patients-tamoxifen.html Cancer Wed, 18 May 2011 10:12:32 EST news224932338 Researchers at the University of California, San Diego School of Medicine have discovered a steroid hormone that inhibits inflammation in the brain. The findings, to be published in the May 13 issue of the journal Cell, have implications for understanding the exaggerated inflammatory responses that are characteristic features of numerous neurodegenerative diseases. http://medicalxpress.com/news/2011-05-sex-hormone-precursor-inhibits-brain.html Medical research Thu, 12 May 2011 12:27:54 EST news224422037 Recently published research shows that coffee drinkers enjoy not only the taste of their coffee but also a reduced risk of cancer with their cuppa. More detailed research published today in BioMed Central's open access journal Breast Cancer Research shows that drinking coffee specifically reduces the risk of antiestrogen-resistant estrogen-receptor (ER)-negative breast cancer. http://medicalxpress.com/news/2011-05-coffee-breast-cancer.html Cancer Wed, 11 May 2011 03:32:02 EST news224303484 In the first large trial of its kind in the United States, researchers have shown that estrogen-lowering drugs can shrink tumors and reduce mastectomy rates for patients with stage 2 or 3 breast cancer. http://medicalxpress.com/news/2011-05-estrogen-lowering-drugs-mastectomy-breast-cancer.html Cancer Mon, 09 May 2011 16:30:49 EST news224177415 A UT Southwestern Medical Center researcher has identified the most comprehensive measurement to date of estrogen's effect on breast cancer cells, showing for the first time how immediate and extensive the effect is. http://medicalxpress.com/news/2011-05-far-reaching-effects-estrogen-breast-cancer.html Cancer Thu, 05 May 2011 13:02:51 EST news223819346