http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have found that when given together, a two-drug combination acts synergistically in test animals modeled with sarcoma tumors. They report that the drug combination of MK-1775 and gemcitabine resulted in a 70 percent decrease in the tumor volume when compared to receiving one drug or the other. http://medicalxpress.com/news/2013-04-two-drug-combo-effective-sarcomas.html Cancer Tue, 09 Apr 2013 14:54:47 EST news284738079 Breast cancers that lack estrogen receptors are more difficult to treat than ER+ cancers. Research presented at the AACR Annual Meeting 2013 demonstrates an investigational drug, Paragazole, that makes triple-negative breast cancer cells express estrogen receptors, and that increases the sensitivity of these cells to chemotherapy. http://medicalxpress.com/news/2013-04-paragazole-excels-preclinical-triple-negative-breast.html Cancer Mon, 08 Apr 2013 09:16:30 EST news284631363 Researchers at Georgia Regents University Cancer Center are investigating a new avenue of treatment to help boost poor pancreatic cancer survival rates. http://medicalxpress.com/news/2013-02-clinical-trial-pancreatic-cancer-survival.html Cancer Tue, 12 Feb 2013 11:50:02 EST news279890541 A multi-center Phase III clinical trial demonstrates that Abraxane (nab-paclitaxel) plus gemcitabine is the first combination of cancer drugs to extend survival of late-stage pancreatic cancer patients compared to standard treatment. http://medicalxpress.com/news/2013-01-drug-combination-pancreatic-cancer-patient.html Cancer Tue, 22 Jan 2013 18:00:01 EST news278097991 Liposarcoma, the most common type of sarcoma, is an often lethal form of cancer that develops in fat cells. It is particularly deadly, in part, because the tumors are not consistently visible with positron emission tomography (PET) scans that use a common probe called FDG and because they frequently do not respond to chemotherapy. http://medicalxpress.com/news/2012-12-scientists-liposarcoma-tumors-chemotherapy.html Cancer Mon, 10 Dec 2012 13:34:43 EST news274368875 An Inserm team in Dijon directed by François Ghiringhelli is to publish an article this week in the Nature Medicine review. The article suggests that two chemotherapy drugs frequently used to treat digestive and breast cancers may encourage the development of tumors by modulating the anti-tumoral immune response. http://medicalxpress.com/news/2012-12-chemotherapy-effectiveness-immune.html Immunology Tue, 04 Dec 2012 13:02:28 EST news273848532 (HealthDay) -- For most patients with locally advanced pancreatic carcinoma (LAPC), induction with a combination of gemcitabine and oxaliplatin (GEMOX) followed by chemoradiotherapy (CRT) is feasible, resulting in clinical benefit, a chance of resectability, and improved survival, according to a study published online July 6 in Cancer. http://medicalxpress.com/news/2012-07-induction-chemo-beneficial-locally-advanced.html Cancer Tue, 17 Jul 2012 15:06:05 EST news261756301 Patients who had surgery for periampullary cancer (a variety of types of cancer that are located in and near the head of the pancreas, including an area called the ampulla where the bile duct joins up with the pancreatic duct to empty their secretions into the upper small intestine) and received chemotherapy had a statistically significant survival benefit, compared to patients who did not receive chemotherapy, after adjusting for prognostic variables, according to a study in the July 11 issue of JAMA. http://medicalxpress.com/news/2012-07-chemotherapy-cancer-pancreas-survival.html Cancer Tue, 10 Jul 2012 16:14:04 EST news261155637 Combining a new targeted therapy with standard chemotherapy may help defeat pancreatic cancer, according to results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held here June 18-21. http://medicalxpress.com/news/2012-06-inhibiting-hedgehog-pathway-pancreatic-cancer.html Cancer Tue, 19 Jun 2012 11:09:35 EST news259322966 Patients with advanced non-small cell lung cancer should only receive treatment with the drug erlotinib before receiving standard chemotherapy if their tumor is known to harbor EGFR mutations, researchers report at the 3rd European Lung Cancer Conference in Geneva, Switzerland. http://medicalxpress.com/news/2012-04-analysis-erlotinib-advanced-non-small-cell.html Cancer Wed, 18 Apr 2012 11:14:35 EST news253966439 The combination of the novel drug TH-302 with the standard drug gemcitabine has shown early signs of delaying the worsening of cancer in patients with advanced pancreatic cancer, a Mayo Clinic-led study has found. This was evaluated using a measure termed progression-free survival (PFS). According to the results of a multi-center Phase II clinical trial, patients receiving the combination of gemcitabine and TH-302 demonstrated a progression-free survival of 5.6 months compared to 3.6 months in those patients who received gemcitabine alone. http://medicalxpress.com/news/2012-04-two-drug-combo-advanced-pancreatic-cancer.html Cancer Tue, 03 Apr 2012 09:48:29 EST news252665289 The dietary supplement gamma-linoleic acid can inhibit the growth of a subset of pancreatic cancer cells and selectively promote cancer cell death in mice, a Mayo Clinic study has found. The supplement, a fatty acid also known as GLA, worked particularly well when combined with the chemotherapy drug gemcitabine, the researchers say. The findings were presented today by Mayo Clinic pathologist Ruth Lupu, Ph.D., at the American Association for Cancer Research (AACR) Annual Meeting 2012. http://medicalxpress.com/news/2012-04-nutritional-supplement-pancreatic-cancer-cells.html Cancer Tue, 03 Apr 2012 09:47:47 EST news252665248 Scientists at Fox Chase Cancer Center are developing a new way to treat pancreatic cancer by boosting the effects of gemcitabine (Gemzar)—the chemotherapy drug that is considered standard therapy for the disease. Although gemcitabine is the first line of defense against pancreatic cancer, many cells find ways to evade the treatment. The new research, which will be presented at the AACR Annual Meeting 2012 on Monday, April 2, found several compounds that appear to improve the cancer-killing effect of gemcitabine. http://medicalxpress.com/news/2012-04-boost-pancreatic-cancer-therapy.html Cancer Mon, 02 Apr 2012 17:30:54 EST news252606640 Pancreas cancer tumors spread quickly and are notoriously resistant to treatment, making them among the deadliest of malignancies. Their resistance to chemotherapy stems in part from a unique biological barrier the tumor builds around itself. Now scientists at Fred Hutchinson Cancer Research Center have found a way to break through that defense, and their research represents a potential breakthrough in the treatment of pancreas cancer. http://medicalxpress.com/news/2012-03-scientists-pancreas-cancer-treatment-barrier.html Cancer Mon, 19 Mar 2012 12:00:01 EST news251375099 Oncologists who treat patients with pancreatic cancer may be one step closer to understanding why gemcitabine, the only currently available treatment, works in some cases but not in others, according to a paper in Cancer Discovery, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-02-combination-therapy-gemcitabine.html Cancer Tue, 28 Feb 2012 10:29:39 EST news249647368 (Medical Xpress) -- New data from the University of Rochester Medical Center confirms that an easier, two-drug chemotherapy regimen given to bladder cancer patients prior to surgery shrinks locally advanced tumors and completely eliminates all evidence of cancer in some patients. http://medicalxpress.com/news/2011-08-less-toxic-chemo-outlook-advanced-bladder.html Cancer Fri, 19 Aug 2011 06:26:21 EST news232953851 (Medical Xpress) -- Tiny tumor proteins circulating in blood may be used to identify which pancreatic cancer patients would benefit from the drug Avastin, researchers at Duke University Medical Center have found. http://medicalxpress.com/news/2011-06-blood-proteins-vulnerability-pancreatic-cancers.html Cancer Tue, 07 Jun 2011 08:47:17 EST news226655214