http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Mutations in HIV that develop during the first few weeks of infection may play a critical role in undermining a successful early immune response, a finding that reveals the importance of vaccines targeting regions of the virus that are less likely to mutate. A new study in the journal PLoS Pathogens, led by researchers at the Ragon Institute of Massachusetts General Hospital, MIT and Harvard and the Broad Institute of MIT and Harvard, applied the same next-generation technologies that have revolutionized sequencing of the human genome to study how HIV adapts within the first few weeks after infection. http://medicalxpress.com/news/2012-03-deeper-view-hiv-reveals-impact.html HIV & AIDS Thu, 08 Mar 2012 17:00:09 EST news250444422 A team of global scientists, led by researchers at Intermountain Medical Center in Salt Lake City, has developed a safer and more accurate way to administer warfarin, one of the most commonly prescribed but also potentially dangerous medications in the United States. http://medicalxpress.com/news/2012-02-safer-common-potentially-dangerous-medication.html Medical research Wed, 29 Feb 2012 10:12:22 EST news249732726 With no lab tests to guide the clinician, psychiatric diagnostics is challenging and controversial. Antisocial personality disorder is defined as "a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood," according to the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) of the American Psychiatric Association. http://medicalxpress.com/news/2012-02-dark-path-antisocial-personality-disorder.html Psychology & Psychiatry Tue, 07 Feb 2012 10:07:25 EST news247831621 Sequencing the entire human genome took more than a decade before leaders of the Human Genome Project announced their completion of a rough draft in a 2000 White House ceremony. Finished in 2003, sequencing that first genome cost nearly $3 billion. Today, with advances in technology, an individual's whole genome can be sequenced in a few months for about $4,000. http://medicalxpress.com/news/2011-12-patients-families-doctors-personalized-genetic.html Genetics Tue, 06 Dec 2011 15:05:32 EST news242406320 When RNA component units called ribonucleotides become embedded in genomic DNA, which contains the complete genetic data for an organism, they can cause problems for cells. It is known that ribonucleotides in DNA can potentially distort the DNA double helix, resulting in genomic instability and altered DNA metabolism, but not much is known about the fate of these ribonucleotides. http://medicalxpress.com/news/2011-12-mechanisms-cells-bits-rna-dna.html Cancer Sun, 04 Dec 2011 13:00:04 EST news242222973 The largest-ever analysis of genetic data related to type 1 diabetes has uncovered new genes associated with the common metabolic disease, which affects 200 million people worldwide. The findings add to knowledge of gene networks involved in the origin of this complex disorder, in which patients depend on frequent insulin injections to control their blood sugar levels. http://medicalxpress.com/news/2011-09-large-meta-analysis-genes-diabetes.html Genetics Thu, 29 Sep 2011 18:19:52 EST news236539177 A new international report from scientists around the world finds that common variants in 28 regions of DNA are associated with blood pressure in human patients. Of the identified regions, most were completely unsuspected, although some harbor genes suspected of influencing blood pressure based on animal studies. In the study receiving advance online publication in Nature, members of the International Consortium for Blood Pressure Genome-Wide Association Studies (ICBP-GWAS) analyzed genetic data from over 275,000 individuals from around the world. They also identified for the first time the involvement of an important physiologic pathway in blood pressure control, potentially leading to a totally new class of hypertension drugs. http://medicalxpress.com/news/2011-09-international-gene-hypertension-treatment.html Genetics Sun, 11 Sep 2011 13:00:58 EST news234964755 A new national collaboration of asthma genetics researchers has revealed a novel gene associated with the disease in African-Americans, according to a new scientific report. http://medicalxpress.com/news/2011-08-asthma-gene-african-americans-replicates.html Genetics Mon, 01 Aug 2011 15:08:19 EST news231430050 The technology that allows scientists to profile the entire genome of individual tumors offers new hope for discovering ways to select the best treatment for each patient's particular type of cancer. However, these profiles produce huge amounts of data, and the volume alone creates unique analytical problems. http://medicalxpress.com/news/2011-06-analysis-method-genomic-cancer.html Genetics Thu, 30 Jun 2011 13:31:37 EST news228659484 More than just a tool for predicting health, modern genetics is upending long-held assumptions about who we are. A new study by Harvard researchers casts new light on the intermingling and migration of European, Middle Eastern and African and populations since ancient times. http://medicalxpress.com/news/2011-05-population-genetics-reveals-ancestries.html Genetics Tue, 24 May 2011 15:01:20 EST news225468060 (Medical Xpress) -- Mayo Clinic researchers have discovered two mutations responsible for a devastating neurological condition they first identified 15 years ago. The researchers say their study -- appearing in Nature Genetics -- has revealed a new neural pathway that may help understand a variety of similar conditions. http://medicalxpress.com/news/2011-05-genetic-neurodegeneration.html Genetics Sun, 01 May 2011 13:29:55 EST news223475372 By dividing individuals with autism spectrum disorders (ASD) into four subtypes according to similarity of symptoms and reanalyzing existing genome-wide genetic data on these individuals vs. controls, researchers at the George Washington University School of Medicine and Health Sciences have identified 18 novel and highly significant genetic markers for ASD. http://medicalxpress.com/news/2011-04-subtype-dependent-genetic-variants-autism-spectrum.html Genetics Wed, 27 Apr 2011 17:16:38 EST news223143369