http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A new study looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. The findings from this first-of-its-kind meta-analysis were reported online May 12 in Nature Genetics by researchers at the Perelman School of Medicine at the University of Pennsylvania. http://medicalxpress.com/news/2013-05-genetic-factors-testicular-cancer.html Genetics Sun, 12 May 2013 13:00:24 EST news287575870 Researchers have identified and validated two DNA methylation markers that could help physicians to more accurately determine a patient's response to epigenetic drugs for treatment of myelodysplastic syndromes (MDS), according to Xiaojing Yang, Ph.D., a postdoctoral fellow at the University of Southern California, Los Angeles, who presented the data at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10. http://medicalxpress.com/news/2013-04-accurate-markers-response-epigenetic-drugs.html Cancer Mon, 08 Apr 2013 08:50:01 EST news284628755 Whole genome sequencing of the DNA code of three prenatal samples provided a detailed map of the locations of their chromosomal abnormalities in 14 days, scientists reported today at the American Society of Human Genetics (ASHG) 2012 meeting in San Francisco. http://medicalxpress.com/news/2012-11-genome-sequencing-de-novo-rearrangements.html Genetics Wed, 07 Nov 2012 13:30:01 EST news271508420 (Medical Xpress)—Researchers have long known that individual diseases are associated with genes in specific locations of the genome. Genetics researchers at the University of North Carolina at Chapel Hill now have shown definitively that a small number of places in the human genome are associated with a large number and variety of diseases. In particular, several diseases of aging are associated with a locus which is more famous for its role in preventing cancer. http://medicalxpress.com/news/2012-09-diseases-aging-hotspots-human-genome.html Genetics Wed, 19 Sep 2012 13:13:43 EST news267279213 Researchers have newly identified three genetic regions associated with primary biliary cirrhosis (PBC), the most common autoimmune liver disease, increasing the number of known regions associated with the disorder to 25. http://medicalxpress.com/news/2012-09-genetic-clues-primary-biliary-cirrhosis.html Genetics Sun, 09 Sep 2012 14:13:13 EST news266418772 Researchers have identified 38 new genetic regions that are associated with glucose and insulin levels in the blood. This brings the total number of genetic regions associated with glucose and insulin levels to 53, over half of which are associated with type 2 diabetes. http://medicalxpress.com/news/2012-08-metabolic-magic-meta-analyses-reveal-genetic.html Genetics Sun, 12 Aug 2012 13:00:27 EST news263813332 (Medical Xpress) -- Understanding the genetic diversity within and between populations has important implications for studies of human disease and evolution. This includes identifying associations between genetic variants and disease, detecting genomic regions that have undergone positive selection and highlighting interesting aspects of human population history. http://medicalxpress.com/news/2012-05-genetic-method-geographic.html Genetics Thu, 24 May 2012 07:04:43 EST news257061871 Age-related macular degeneration (AMD) is a common disease that can result in blindness. It is caused by cell death in the eye’s retina, which is partly responsible for transforming visual stimuli into electrical signals to the brain. Asian populations tend to exhibit a particular type of the disease, called exudative AMD, which includes changes in the blood vessels of the eye. Caucasians, however, tend to exhibit AMD without these vascular abnormalities. Now, a research team led by Michiaki Kubo at the RIKEN Center for Genomic Medicine in Yokohama has identified four genomic areas that increase the risk for exudative AMD in Japanese individuals. http://medicalxpress.com/news/2012-01-eye-japanese-genome.html Diseases, Conditions, Syndromes Fri, 13 Jan 2012 08:30:06 EST news245664760 (Medical Xpress) -- An international team of scientists, including researchers from Karolinska Institutet, have identified several rare gene variants that predispose to IBD (Inflammatory Bowel Disease). The study provides new insights into disease pathogenesis, and suggests next-generation sequencing may speed hoped-for personalized treatment of common complex disorders. http://medicalxpress.com/news/2011-10-rare-gene-variants-linked-inflammatory.html Inflammatory disorders Mon, 10 Oct 2011 10:26:51 EST news237461097 Researchers have shown they can reverse the aging process for human adult stem cells, which are responsible for helping old or damaged tissues regenerate. The findings could lead to medical treatments that may repair a host of ailments that occur because of tissue damage as people age. A research group led by the Buck Institute for Research on Aging and the Georgia Institute of Technology conducted the study in cell culture, which appears in the September 1, 2011 edition of the journal Cell Cycle. http://medicalxpress.com/news/2011-09-scientists-clock-adult-stem-cells.html Medical research Tue, 20 Sep 2011 15:46:00 EST news235752345 Lung adenocarcinomas in people who have never smoked show greater genome instability than those in smokers, supporting the theory that lung cancer in never smokers arises through different pathways, according to research presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer (IASLC). http://medicalxpress.com/news/2011-07-lung-tumors-never-smokers-greater-genomic.html Cancer Tue, 05 Jul 2011 04:50:46 EST news229060229