http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. For the first time, scientists show that a leading cause of liver transplant, primary sclerosing cholangitis (PSC), is a distinct disease from inflammatory bowel disease, opening up new avenues for specific PSC treatments. http://medicalxpress.com/news/2013-04-large-scale-genetic-relationship-primary-sclerosing.html Genetics Sun, 21 Apr 2013 13:00:17 EST news285763950 A new form of genetic testing of the bacteria that causes tuberculosis can provide better information on TB transmission and also trace TB outbreaks more accurately than the current standard test, according to a study from Germany published in this week's PLOS Medicine. http://medicalxpress.com/news/2013-02-genome-sequencing-tb-outbreaks-standard.html Diseases, Conditions, Syndromes Tue, 19 Feb 2013 17:10:08 EST news279910834 (Medical Xpress)—Platelet disorders are heavily underdiagnosed, little understood and cannot be cured. University of Birmingham researchers and the Birmingham Platelet Group are running a UK-wide clinical trial 'Genotyping and platelet phenotyping' (GAPP) funded by the British Heart Foundation (BHF). The trial includes lab research by BHF-funded scientist Dr Yotis Senis in an effort to better identify patients and potentially to develop new treatments. http://medicalxpress.com/news/2013-02-mystery-disorders-unraveled-efforts.html Medical research Mon, 11 Feb 2013 07:44:35 EST news279791066 Exon 20 insertions are the third most common family of epidermal growth factor receptor (EGFR) mutations found in non–small-cell lung cancer (NSCLC). Little is known about cancers harboring these mutations aside from their lack of response to EGFR tyrosine kinase inhibitors, impairing the development of effective targeted therapies. A recent study published in the February 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concludes that patients with EGFR exon 20 insertions have similar clinical characteristics to those with common EGFR mutations, but a poorer prognosis. http://medicalxpress.com/news/2013-01-patients-egfr-exon-insertions-poorer.html Cancer Tue, 15 Jan 2013 11:16:49 EST news277470992 (HealthDay)—For women affected by familial breast cancer, a polygenic risk score based on 22 genomic variants can identify women at high-risk of breast cancer, according to a study published in the Dec. 10 issue of the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-12-polygenic-score-women-familial-breast.html Cancer Tue, 18 Dec 2012 18:30:01 EST news275076443 A gene so powerful it nearly triples the risk of Alzheimer's disease has been discovered by an international team including researchers from Mayo Clinic. It is the most potent genetic risk factor for Alzheimer's identified in the past 20 years. The findings were reported Wednesday in the online edition of the New England Journal of Medicine. http://medicalxpress.com/news/2012-11-rare-genetic-mutation-triples-alzheimer.html Alzheimer's disease & dementia Wed, 14 Nov 2012 18:10:15 EST news272129519 (HealthDay)—Genotyping of two genetic risk alleles can be used to estimate the long-term risk of early and late age-related macular degeneration (AMD), but knowing the phenotype is important in assessing risk when early AMD is present, according to a study published online Nov. 9 in the Archives of Ophthalmology. http://medicalxpress.com/news/2012-11-genotyping-ids-long-term-macular-degeneration.html Ophthalmology Tue, 13 Nov 2012 18:10:04 EST news272048480 Researchers from East Carolina University used a new technique of genotyping to identify the source of a hematology clinic outbreak of Mycobacterium mucogenicum, a gram-positive, acid-fast bacteria found in tap water. This is the first outbreak of M. mucogenicum in an ambulatory care setting; five other outbreaks have been reported in hospital settings since 1995. The study was published in the November issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America. http://medicalxpress.com/news/2012-10-genotyping-source-clinic-infection-outbreak.html Diseases, Conditions, Syndromes Fri, 05 Oct 2012 11:31:41 EST news268655490 Researchers have identified 38 new genetic regions that are associated with glucose and insulin levels in the blood. This brings the total number of genetic regions associated with glucose and insulin levels to 53, over half of which are associated with type 2 diabetes. http://medicalxpress.com/news/2012-08-metabolic-magic-meta-analyses-reveal-genetic.html Genetics Sun, 12 Aug 2012 13:00:27 EST news263813332 (HealthDay) -- Researchers have identified three previously unreported instances of severe opioid-induced toxicity in children following adenotonsillectomy for obstructive sleep apnea syndrome, according to a case report published online April 9 in Pediatrics. http://medicalxpress.com/news/2012-04-highlights-child-deaths-post-surgery-codeine.html Sleep apnea Mon, 09 Apr 2012 13:50:02 EST news253195977 Developed in Canada and conducted by researchers from the University of Ottawa Heart Institute, in partnership with Spartan Bioscience, the world's first bedside genetic test has received acknowledgment by The Lancet, the world's leading general medical journal. http://medicalxpress.com/news/2012-03-world-bedside-genetic-green-lancet.html Cardiology Thu, 29 Mar 2012 11:21:58 EST news252238889 Can pregnant women help boost their children's brainpower by eating fish? The findings of a study, presented in the American Journal of Clinical Nutrition, show how children born to women who consumed more fish during their pregnancies demonstrated improved outcomes in tests for verbal intelligence, fine motor skills and prosocial behavior. http://medicalxpress.com/news/2012-01-fish-brainpower.html Health Tue, 10 Jan 2012 10:53:43 EST news245415209 If you had a family history of developing Alzheimer's disease, would you take a genetic test that would give you more information about your chances? http://medicalxpress.com/news/2011-12-alzheimers-genetic-results.html Diseases, Conditions, Syndromes Mon, 12 Dec 2011 11:21:46 EST news242911288 Investigators have identified a human chromosome containing a specific gene associated with susceptibility to herpes simplex labialis (HSL), the common cold sore. Published in the Journal of Infectious Diseases and now available online, the study looks at how several genes may affect the severity of symptoms and frequency of this common infection. The findings, if confirmed, could have implications for the development of new drugs to treat outbreaks. http://medicalxpress.com/news/2011-10-specific-gene-linked-cold-sore.html Diseases, Conditions, Syndromes Fri, 28 Oct 2011 04:28:41 EST news238994797 Are you genetically predisposed to tuberculosis? Scientists may now be able to answer this question and doctors may be able to adjust their therapeutic approach based on what they learn. That's because new research presented in the Journal of Leukocyte Biology suggests that two frequent mutations in an immune system gene called TLR1 are responsible for cellular changes that ultimately make us less likely to resist the disease. http://medicalxpress.com/news/2011-08-discovery-customized-tuberculosis-therapies-based.html Diseases, Conditions, Syndromes Mon, 01 Aug 2011 11:50:23 EST news231416433