http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A type of low-grade but sometimes lethal brain tumor in children has been found in many cases to contain an unusual mutation that may help to classify, diagnose and guide the treatment of the tumors, report scientists at Dana-Farber Cancer Institute. http://medicalxpress.com/news/2013-04-scientists-mutation-pediatric-brain-tumors.html Genetics Tue, 30 Apr 2013 17:28:13 EST news286561685 Glioblastoma, the most common and lethal form of brain tumor in adults, is challenging to treat because the tumors rapidly become resistant to therapy. As cancer researchers are learning more about the causes of tumor cell growth and drug resistance, they are discovering molecular pathways that might lead to new targeted therapies to potentially treat this deadly cancer. http://medicalxpress.com/news/2013-02-combination-therapy-route-glioblastoma-tumor.html Cancer Tue, 26 Feb 2013 13:29:15 EST news281107744 One of the most common types of brain tumors in adults, glioblastoma multiforme, is one of the most devastating. Even with recent advances in surgery, radiation and chemotherapy, the aggressive and invasive tumors become resistant to treatment, and median survival of patients is only about 15 months. In a study published in Neuro-Oncology, researchers at Mayo Clinic identify an important association between the naturally occurring enzyme Kallikrein 6, also known as KLK6, and the malignant tumors. http://medicalxpress.com/news/2013-01-enzyme-involved-deadly-brain-tumors.html Cancer Thu, 17 Jan 2013 14:48:11 EST news277656484 Using an artificial protein that stimulates the body's natural immune system to fight cancer, a research team at Duke Medicine has engineered a lethal weapon that kills brain tumors in mice while sparing other tissue. If it can be shown to work in humans, it would overcome a major obstacle that has hampered the effectiveness of immune-based therapies. http://medicalxpress.com/news/2012-12-immune-therapy-successfully-brain-tumors.html Immunology Mon, 17 Dec 2012 15:00:07 EST news274959213 Researchers at Columbia University Medical Center (CUMC) have discovered that some cases of glioblastoma, the most common and aggressive form of primary brain cancer, are caused by the fusion of two adjacent genes. The study also found that drugs that target the protein produced by this genetic aberration can dramatically slow the growth of glioblastomas in mice. The findings were published today in the online edition of the journal Science. http://medicalxpress.com/news/2012-07-genetic-lethal-brain-tumor-treatment.html Cancer Thu, 26 Jul 2012 14:00:01 EST news262521194 Researchers at Northwestern Brain Tumor Institute (NBTI) are seeking to understand if a vaccine made from a patient's own blood cells may slow the growth of a type of brain tumor. The trial is studying the vaccine's effect on glioblastoma multiformes (GBM), the most common and aggressive type of primary brain tumor. The trial is an example of a growing trend in cancer research that seeks to understand if vaccines can be used to turn a person's own immune system into a weapon against cancers by slowing the growth of tumors. http://medicalxpress.com/news/2012-07-vaccine-potential-weapon-aggressive-brain.html Cancer Tue, 24 Jul 2012 17:05:50 EST news262368345 An international research team led by the Research Institute of the McGill University Health Centre (RI MUHC) has made a major genetic breakthrough that could change the way pediatric cancers are treated in the future. The researchers identified two genetic mutations responsible for up to 40 per cent of glioblastomas in children - a fatal cancer of the brain that is unresponsive to chemo and radiotherapy treatment. The mutations were found to be involved in DNA regulation, which could explain the resistance to traditional treatments, and may have significant implications on the treatment of other cancers. The study was published this week in the journal Nature. http://medicalxpress.com/news/2012-01-genetic-breakthrough-brain-cancer-children.html Cancer Mon, 30 Jan 2012 10:30:02 EST news247141164 Glioblastoma, a lethal brain cancer, is one of the most resistant to available therapies and patients typically live approximately 15 months. http://medicalxpress.com/news/2012-01-pathway-glioblastoma-resistance.html Cancer Tue, 24 Jan 2012 11:37:28 EST news246627439 A small percentage of the deadly brain tumors called glioblastomas, which usually resist treatment with drugs targeting mutations in cell-growth genes, appears to contain extra copies of two or three of these genes at the same time. The surprising discovery by a Massachusetts General Hospital (MGH)-based research team has major implications for the understanding of tumor biology – including the evolution of tumor cell populations – and for targeted cancer therapies. http://medicalxpress.com/news/2011-12-amplification-multiple-cell-growth-genes-brain.html Cancer Thu, 01 Dec 2011 12:50:04 EST news241965316 Glioblastoma multiforme (GBM) is the most common malignant brain cancer in humans. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies. http://medicalxpress.com/news/2011-11-glioblastoma-multiforme-dock.html Cancer Mon, 14 Nov 2011 12:32:01 EST news240496299 The metabolic state of glioma stem cells, which give rise to deadly glioblastomas, is significantly different from that of the brain cancer cells to which they give birth, a factor which helps those stem cells avoid treatment and cause recurrence later. http://medicalxpress.com/news/2011-09-metabolic-state-brain-cancer-stem.html Cancer Tue, 06 Sep 2011 16:43:16 EST news234546183