https://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. UVA Comprehensive Cancer Center scientists have identified a molecule that blocks the gene responsible for glioblastoma, raising hopes that the molecule could become a much-needed new treatment for the deadliest brain cancer. Researcher Hui Li, Ph.D., previously discovered the "oncogene" responsible for glioblastoma, a cancer for which there are no treatments that extend life for more than a few months. In his follow-up work, published in Science Translational Medicine, Li reports the identification of a small molecule that blocked the gene's activity in both cell samples and lab mice. In mice, the molecule proved effective without unwanted or harmful side effects. https://medicalxpress.com/news/2026-02-small-molecule-blocks-key-glioblastoma.html Wed, 04 Feb 2026 15:19:54 EST news689440741 Results from a pilot clinical trial evaluating the safety and feasibility of repeated focused ultrasound-induced blood–brain barrier (BBB) opening combined with the monoclonal antibody drug Avastin (bevacizumab) in patients with recurrent glioblastoma were published in Neurosurgery. With the success of the pilot, the study's next phase—the pivotal trial—is now enrolling participants. https://medicalxpress.com/news/2026-02-focused-ultrasound-glioblastoma-gbm-clinical.html Tue, 03 Feb 2026 00:20:02 EST news689263954 A study by Brown University Health researchers has identified a crucial factor that may help improve treatment for glioblastoma, one of the most aggressive and common forms of adult brain cancer. The findings, published in Cell Reports, reveal how differences among cells within a single tumor influence the cancer's response to chemotherapy, and introduce a promising new therapy designed to tip the odds in the patients' favor. https://medicalxpress.com/news/2026-02-tumor-chaos-uncover-key-glioblastoma.html Mon, 02 Feb 2026 09:14:46 EST news689246041 A team of Canadian scientists has uncovered a new way to slow the growth of glioblastoma, the most aggressive and currently incurable form of brain cancer—and identified an existing medication that could treat it. https://medicalxpress.com/news/2026-01-scientists-uncover-hidden-cells-fueling.html Wed, 21 Jan 2026 11:00:08 EST news688120321 Researchers have developed a new computational approach that uncovers possible drugs for specific cellular targets for treating glioblastoma, a lethal brain tumor. This approach enabled them to predict more effective treatment combinations to fight the disease on an individualized basis. https://medicalxpress.com/news/2026-01-algorithm-drugs-glioblastoma-diverse-cell.html Wed, 07 Jan 2026 05:00:03 EST news686853362 Researchers at the UNC School of Medicine and the UNC Eshelman School of Pharmacy have made a breakthrough that could modernize treatment for glioblastoma. In a study published in Proceedings of the National Academy of Sciences, they found that combining a common chemotherapy drug with a chemical called EdU provided unprecedented survival and cancer remission in various preclinical glioblastoma models. https://medicalxpress.com/news/2026-01-combination-therapy-brain-cancer-effective.html Mon, 05 Jan 2026 14:44:31 EST news686846641 The effectiveness of chemotherapy for brain cancer, done with a technique that opens the blood-brain barrier, can be monitored by blood draw, researchers at Northwestern Medicine and the University of Michigan have shown. https://medicalxpress.com/news/2025-12-blood-analysis-brain-cancer-treatment.html Tue, 16 Dec 2025 14:10:03 EST news685116137 Research by University of Sydney scientists has uncovered a mechanism that may explain why glioblastoma returns after treatment, offering new clues for future therapies which they will now investigate as part of an Australian industry collaboration. https://medicalxpress.com/news/2025-12-fertility-gene-glioblastoma-tumors-survive.html Mon, 15 Dec 2025 05:00:01 EST news684756542 Glioblastoma is the most common form of brain cancer in adults, and its consequences are usually quick and fatal. After receiving standard-of-care treatment (surgery followed by radiation and chemotherapy), fewer than half of patients will survive longer than 15 months. Only 5% of patients survive longer than five years. https://medicalxpress.com/news/2025-12-immunotherapy-glioblastoma-cell-interactions.html Fri, 12 Dec 2025 11:05:35 EST news684759901 Researchers at Mass General Brigham have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells. A single dose of the modified virus increased T-cell, natural killer cell, and myeloid cell responses in the tumor microenvironment and increased the overall survival in preclinical models. Results are published in Nature Cancer. https://medicalxpress.com/news/2025-12-herpes-virus-destroy-glioblastoma-preclinical.html Thu, 04 Dec 2025 12:44:40 EST news684074641 Electrotherapy using injectable nanoparticles delivered directly into the tumor could pave the way for new treatment options for glioblastoma, according to a new study from Lund University in Sweden. https://medicalxpress.com/news/2025-12-electrotherapy-nanoparticles-glioblastoma-treatment.html Mon, 01 Dec 2025 15:41:14 EST news683826021 Researchers at Washington University School of Medicine in St. Louis, along with collaborators at Northwestern University, have developed a noninvasive approach to treat one of the most aggressive and deadly brain cancers. Their technology uses precisely engineered structures assembled from nano-size materials to deliver potent tumor-fighting medicine to the brain through nasal drops. The novel delivery method is less invasive than similar treatments in development and was shown in mice to effectively treat glioblastoma by boosting the brain's immune response. https://medicalxpress.com/news/2025-11-nasal-nanomedicine-immune-boosting-therapy.html Sat, 22 Nov 2025 07:09:20 EST news683017743 With a five-year survival rate of less than 5%, glioblastoma is one of the most aggressive types of brain cancer. Until now, all available treatments, including immunotherapy—which involves strengthening the immune system to fight cancer—have proved disappointing. CAR-T cells are genetically modified immune cells manufactured in the laboratory and designed to identify and destroy cancer cells. https://medicalxpress.com/news/2025-11-immune-cells-destroy-glioblastoma-animal.html Thu, 20 Nov 2025 14:30:04 EST news682871402 Glioblastoma is one of the most aggressive and complex brain cancers. It grows quickly, resists standard treatments, and often leaves patients and their families searching for every possible option. https://medicalxpress.com/news/2025-11-access-specialized-cancer-centers-affects.html Tue, 04 Nov 2025 12:10:06 EST news681478664 Glioblastoma is an aggressive brain cancer that almost always recurs after surgery and radiochemotherapy. Now, researchers have developed a biodegradable implant that can be placed directly into the brain cavity after tumor removal. This so-called wafer, nicknamed CANDI, slowly releases drugs to myeloid cells—a certain immune cell population abundant in glioblastoma—"waking up" these immune cells and helping them fight off any leftover cancer cells. https://medicalxpress.com/news/2025-10-implantable-candi-wafer-glioblastoma-recurrence.html Wed, 29 Oct 2025 09:05:04 EDT news680947502 Scientists at Montefiore Einstein Comprehensive Cancer Center (MECCC) and Albert Einstein College of Medicine have shown for the first time that glioblastoma—the deadliest form of brain cancer—affects not just the brain but also erodes the skull, alters the makeup of skull marrow, and interferes with the body's immune response. Drugs intended to inhibit skull-bone loss made the cancer more aggressive, according to results published in Nature Neuroscience. The paper is titled "Brain Tumors Induce Widespread Disruption of Calvarial Bone and Alteration of Skull Marrow Immune Landscape." https://medicalxpress.com/news/2025-10-glioblastomas-affect-brain-scientists.html Fri, 03 Oct 2025 05:00:18 EDT news678619381 A new study, led by researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, captured details of glioblastoma that had never before been seen and revealed a surprise finding: Glioblastoma cells that "cluster" together with other cells of the same type are less deadly than those that disperse from these clusters. The findings were also corroborated in breast cancer samples and point to a possible new general principle of solid tumor biology. https://medicalxpress.com/news/2025-09-glioblastoma-cells-unstick-neighbors-deadly.html Thu, 18 Sep 2025 11:00:03 EDT news677317801 To move forward or migrate, the different cells in our body must exert forces or interact with their surrounding environment. Interestingly, however, a fault in these interactions can also be the reason for the spread of deadly cancer cells, such as in a brain tumor, or glioblastoma. While the importance of these interactions is well-understood, the machinery involved in these interactions at the molecular level remains a mystery. https://medicalxpress.com/news/2025-09-interactions-cell-migration-brain-cancer.html Fri, 12 Sep 2025 10:02:03 EDT news676890122 An international team of scientists has revealed how rogue rings of DNA that float outside of our chromosomes—known as extrachromosomal DNA, or ecDNA—can drive the growth of a large proportion of glioblastomas, the most common and aggressive adult brain cancer. The discovery could open the door to much-needed new approaches to diagnose glioblastoma early, track its progress and treat it more effectively. https://medicalxpress.com/news/2025-09-rogue-dna-reveal-earliest-clues.html Mon, 08 Sep 2025 10:00:01 EDT news676293823 Research has revealed a new mechanism within cancer cells that could be exploited to treat glioblastoma—one of the deadliest types of brain tumors. https://medicalxpress.com/news/2025-09-reveals-protein-adar1-therapeutic-brain.html Tue, 02 Sep 2025 13:40:03 EDT news676039039 Scientists have found a way to stop brain cancer cells spreading by essentially 'freezing' a key molecule in the brain. https://medicalxpress.com/news/2025-09-brain-cancer-cells-reprogrammed.html Tue, 02 Sep 2025 13:19:04 EDT news676037941 Blocking brain damage triggered by a glioblastoma, an aggressive brain cancer, may slow the growth of the cancer and allow the brain to keep working better for longer, according to a new study led by UCL (University College London) researchers. https://medicalxpress.com/news/2025-08-blocking-brain-glioblastoma-growth.html Wed, 20 Aug 2025 11:00:03 EDT news674841841 University of Kentucky Markey Cancer Center researchers have discovered a genetic biomarker that could help identify patients with glioblastoma most likely to benefit from the cancer drug bevacizumab. https://medicalxpress.com/news/2025-07-genetic-marker-brain-cancer-treatment.html Fri, 25 Jul 2025 07:43:04 EDT news672648182 Advanced treatments, known as immunotherapies that activate T cells—our body's immune cells—to eliminate cancer cells, have shown limited efficacy as standalone therapies for glioblastoma, the most lethal form of brain tumor. This is due to their minimal response to glioblastoma and high resistance to treatment. https://medicalxpress.com/news/2025-07-gut-microbes-tryptophan-immunotherapy-difficult.html Wed, 02 Jul 2025 09:10:09 EDT news670666203 A new study led by Keck Medicine of USC researchers may have uncovered an effective combination therapy for glioblastoma, a brain tumor diagnosis with few available effective treatments. According to the National Brain Tumor Society, the average survival for patients diagnosed with glioblastoma is eight months. https://medicalxpress.com/news/2025-06-electric-fields-supercharge-immune-deadliest.html Mon, 09 Jun 2025 12:06:04 EDT news668689561 Virginia Tech researchers are developing more precise treatments for pediatric brain cancer using a new class of therapies that target cancer cells while sparing healthy tissue. https://medicalxpress.com/news/2025-06-aims-treatment-pediatric-brain-cancer.html Wed, 04 Jun 2025 05:55:04 EDT news668235301 Most of the cells in our bodies don't move—they stay where they're supposed to in service to our organs and biological systems. But aggressive cancer cells behave differently, spreading and ultimately damaging the tissues they invade. https://medicalxpress.com/news/2025-06-genetic-circuit-discovery-cell-migration.html Tue, 03 Jun 2025 10:30:04 EDT news668165401 The genetic makeup and structure of glioblastoma tumors can shift dramatically across different regions of a single tumor, according to a Northwestern Medicine study published in Science Advances. https://medicalxpress.com/news/2025-06-genomic-complexities-glioblastoma-tumors.html Mon, 02 Jun 2025 10:55:03 EDT news668080501 A lab-designed molecule developed and extensively studied by scientists with Virginia Tech's Fralin Biomedical Research Institute at VTC could represent a breakthrough in slowing tumor recurrence in glioblastoma, an aggressive and deadly form of brain cancer. https://medicalxpress.com/news/2025-05-scientists-peptide-drug-combat-deadly.html Thu, 29 May 2025 09:45:04 EDT news667730701 A series of preclinical studies show that a new compound, SHP1705, targets circadian clock proteins hijacked by glioblastoma stem cells, impairing the cancer cells' ability to survive and grow. SHP1705 is also the first clock-targeting compound to complete a phase 1 clinical trial, where it was found to be safe and well-tolerated in humans. A summary of the research is published in the journal Neuro-Oncology. https://medicalxpress.com/news/2025-05-experimental-compound-circadian-clock-machinery.html Mon, 12 May 2025 16:43:04 EDT news666286982