http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A DNA variant near a digestive enzyme does not only affect risk of developing diabetes but also affects the response to treatment, an international consortium of researchers including the University of Dundee has found. http://medicalxpress.com/news/2013-05-dna-variant-affects-diabetes-treatment.html Diabetes Fri, 17 May 2013 08:10:03 EST news287996295 Two professors believe they may have a promising lead from which to develop a new treatment for obesity and diabetes. http://medicalxpress.com/news/2013-04-treatment-obesity-diabetes.html Overweight and Obesity Thu, 25 Apr 2013 07:35:54 EST news286094146 (Medical Xpress)—Individuals who had taken a type of drug commonly used to treat Type 2 diabetes showed abnormalities in the pancreas, including cell proliferation, that may be associated with an increased risk of neuroendocrine tumors, according to a new study by researchers from UCLA and the University of Florida. Their findings were published online March 22 in the journal Diabetes. http://medicalxpress.com/news/2013-03-popular-diabetes-drugs-abnormal-pancreatic.html Diabetes Wed, 27 Mar 2013 07:27:52 EST news283588058 A class of medications commonly prescribed to lower blood sugar in diabetic patients appears to protect them from developing heart failure, according to a study at Henry Ford Hospital in Detroit. http://medicalxpress.com/news/2013-03-diabetic-medication-patients-heart-failure.html Cardiology Sun, 10 Mar 2013 12:53:17 EST news282138790 (HealthDay)—Feeding obese-prone rats a high-fat diet leads to impaired satiation signaling through glucagon-like peptide-1 (GLP-1), a gastrointestinal hormone that suppresses food intake and helps regulate energy balance, according to a study published online Feb. 19 in Diabetes. http://medicalxpress.com/news/2013-02-high-fat-diet-impairs-satiation-obese-prone.html Diabetes Wed, 27 Feb 2013 15:40:01 EST news281200420 People who take the newest class of diabetes drugs to control blood sugar are twice as likely as those on other forms of sugar-control medication to be hospitalized with pancreatitis, Johns Hopkins researchers report. http://medicalxpress.com/news/2013-02-pancreatitis-class-diabetes-drugs.html Medications Mon, 25 Feb 2013 16:00:07 EST news281009581 Preliminary evidence from a clinical trial suggests that treatment with glucagon-like peptide-1 (GLP-1) receptor agonists was associated with reduced body mass index and body weight in adolescents with severe obesity, according to a report published Online First by JAMA Pediatrics. http://medicalxpress.com/news/2013-02-glucagon-like-peptide-receptor-agonists-adolescent.html Pediatrics Mon, 04 Feb 2013 16:00:12 EST news279197910 (HealthDay)—For patients with type 2 diabetes taking metformin monotherapy, the bile acid sequestrant colesevelam reduces fasting and postprandial glucose concentrations without any effects on insulin concentration, secretion, or action, according to research published online Dec. 18 in Diabetes. http://medicalxpress.com/news/2013-01-bile-acid-sequestrant-glucose-t2dm.html Diabetes Wed, 30 Jan 2013 16:10:01 EST news278781849 A team, led by senior author Morris J. Birnbaum, MD, PhD, the Willard and Rhoda Ware Professor of Medicine, with the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, found that the diabetes drug metformin works in a different way than previously understood. Their research in mice found that metformin suppresses the liver hormone glucagon's ability to generate an important signaling molecule, pointing to new drug targets. The findings were published online this week in Nature. http://medicalxpress.com/news/2013-01-most-used-diabetes-drug-previously-thought.html Diabetes Sun, 06 Jan 2013 13:00:31 EST news276685322 (HealthDay)—For patients with short bowel syndrome with intestinal failure (SBS-IF), the glucagon-like peptide 2 analogue teduglutide appears to be safe and reduces the number of days off parenteral support, according to a phase 3 study published in the December issue of Gastroenterology. http://medicalxpress.com/news/2012-12-teduglutide-effective-safe-short-bowel.html Diseases, Conditions, Syndromes Wed, 12 Dec 2012 13:30:01 EST news274540602 Researchers at Karolinska Institutet in Sweden have shown that the cells that produce glucagon are stimulated by the hormone itself. A previous study by the same group demonstrated that this principle also applies to insulin. This means that a feedback system is at work in the body, whereby hormone secreting cells receive an immediate signal to produce more of the hormone. http://medicalxpress.com/news/2012-12-glucagon-synthesis.html Medical research Mon, 03 Dec 2012 15:00:10 EST news273755404 A collaboration between scientists in Munich, Germany and Bloomington, USA may have overcome one of the major challenges drug makers have struggled with for years: Delivering powerful nuclear hormones to specific tissues, while keeping them away from others. http://medicalxpress.com/news/2012-11-diabetes-turbo-charged-gut-hormones.html Medical research Tue, 13 Nov 2012 11:27:54 EST news272028400 Scientists at Joslin Diabetes Center have identified biological mechanisms by which glucagon-like peptide-1 (GLP-1), a gut hormone, protects against kidney disease, and also mechanisms that inhibit its actions in diabetes. The findings, which are reported today online by Diabetes, may lead to the development of new therapeutic agents that harness the actions of GLP-1 to prevent the harmful effects of hyperglycemia on renal endothelial cells. http://medicalxpress.com/news/2012-07-joslin-gain-diabetes-kidney-disease.html Diseases, Conditions, Syndromes Mon, 23 Jul 2012 10:27:42 EST news262258055 Fruit flies on dietary restriction (DR) need to be physically active in order to get the lifespan extending benefits that come from their Spartan diet. If the same axiom holds true in humans, those practicing caloric restriction in hopes of living longer need to make sure they eat enough to avoid fatigue. http://medicalxpress.com/news/2012-07-physical-reap-benefits-dietary-restriction.html Medical research Mon, 02 Jul 2012 12:00:02 EST news260448824 (HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) the absolute incretin effect is reduced compared with healthy individuals, but its relative importance is increased, particularly in first-phase insulin secretion, according to a study published online June 20 in Diabetes. http://medicalxpress.com/news/2012-06-absolute-incretin-effect-diabetes.html Diabetes Mon, 25 Jun 2012 14:35:04 EST news259853673 Researchers have discovered how a hormone in the gut slows the rate at which the stomach empties and thus suppresses hunger and food intake. Results of the animal study will be presented at The Endocrine Society's 94th Annual Meeting in Houston. http://medicalxpress.com/news/2012-06-gut-hormone-receptor-brain-key.html Overweight and Obesity Mon, 25 Jun 2012 13:30:01 EST news259847813 (HealthDay) -- In adolescents with type 1 diabetes the glucagon response to hypoglycemia is lost as early as one month and at a median of eight months after diabetes diagnosis, according to a study published online June 14 in Diabetes Care. http://medicalxpress.com/news/2012-06-early-loss-glucagon-response-hypoglycemia.html Diabetes Fri, 22 Jun 2012 11:30:01 EST news259577602 A new link between obesity and type 2 diabetes found in mice could open the door to exploring new potential drug treatments for diabetes, University of Michigan Health System research has found. http://medicalxpress.com/news/2012-05-inflammation-hormone-link-pave-drugs.html Diabetes Tue, 15 May 2012 13:41:04 EST news256308049 Maintaining the right level of sugar in the blood is the responsibility not only of insulin, which removes glucose, but also of a hormone called glucagon, which adds glucose. http://medicalxpress.com/news/2012-04-glucagon-pathway-approach-diabetes.html Diabetes Thu, 12 Apr 2012 12:00:17 EST news253443358 In their extraordinary quest to decode human metabolism, researchers at the Salk Institute for Biological Studies have discovered a pair of molecules that regulates the liver's production of glucose -- the simple sugar that is the source of energy in human cells and the central player in diabetes. http://medicalxpress.com/news/2012-04-molecular-liver-glucose-production-ii.html Medical research Sun, 08 Apr 2012 13:00:29 EST news253084650 (HealthDay) -- Genetic variants associated with type 2 diabetes that affect glucagon-like peptide 1 (GLP-1) are not associated with GLP-1 levels or GLP-1-induced insulin secretion in healthy individuals, according to a study published online March 28 in Diabetes. http://medicalxpress.com/news/2012-04-importance-diabetes-genetic-variants-unclear.html Diabetes Wed, 04 Apr 2012 12:50:01 EST news252762281 (HealthDay) -- Drinking a diet soda before a glucose load is associated with increased glucagon-like peptide 1 (GLP-1) secretion in individuals with type 1 diabetes and healthy controls, but not in those with type 2 diabetes, according to research published online March 12 in Diabetes Care. http://medicalxpress.com/news/2012-03-diet-soda-linked-glucagon-like-peptide.html Diabetes Thu, 22 Mar 2012 16:20:02 EST news251650831 Giving overweight or obese patients a gut hormone that suppresses appetite leads to clinically beneficial weight loss as well as reduced blood pressure and cholesterol levels, finds a study published in the British Medical Journal today. http://medicalxpress.com/news/2012-01-gut-hormone-weight-loss-overweight.html Overweight and Obesity Tue, 10 Jan 2012 18:54:21 EST news245444054 Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have discovered a new protein that may play a critical role in how the human body regulates blood sugar levels. Reporting in the current issue of Pancreas, the research team says the protein may represent a new target for treating type 1 diabetes. http://medicalxpress.com/news/2012-01-protein-diabetes.html Medical research Wed, 04 Jan 2012 10:54:31 EST news244896822 Two newer drugs used to treat Type 2 diabetes could be linked to a significantly increased risk of developing pancreatitis and pancreatic cancer, and one could also be linked to an increased risk of thyroid cancer, according to a new UCLA study. http://medicalxpress.com/news/2011-09-link-diabetes-drugs-pancreatic-cancer.html Medications Fri, 16 Sep 2011 16:52:43 EST news235410714