http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Transformative research from Western University has identified new hormones in the body which may suppress breast cancer and stimulate the regression of breast tumors. http://medicalxpress.com/news/2013-05-breast-cancer-hormone.html Cancer Fri, 24 May 2013 08:30:04 EST news288600254 Estrogen and progesterone receptors, and the gene HER2 – these are the big three markers and/or targets in breast cancer. Evidence presented at the AACR Annual Meeting 2013 adds a fourth: androgen receptors. http://medicalxpress.com/news/2013-04-evidence-androgen-breast-cancer.html Cancer Wed, 10 Apr 2013 09:16:19 EST news284804172 A newly identified set of genes may predict which women are at high risk for getting breast cancer that is sensitive to estrogen and, therefore, would be helped by taking drugs to prevent it, reports a new Northwestern Medicine study. http://medicalxpress.com/news/2013-03-genes-breast-cancer-aid.html Cancer Tue, 19 Mar 2013 13:21:54 EST news282918105 Mice with many of the pathologies of Alzheimer's Disease showed fewer signs of the disease when given a protein-restricted diet supplemented with specific amino acids every other week for four months. http://medicalxpress.com/news/2013-02-low-protein-diet-alzheimer-mice.html Alzheimer's disease & dementia Thu, 14 Feb 2013 11:50:01 EST news280064039 (Medical Xpress)—In the first study to examine discussion of drug side effects on Internet message boards, researchers from the Perelman School of Medicine at the University of Pennsylvania found that breast cancer survivors taking the commonly prescribed adjuvant therapy known as aromatase inhibitors (AIs) often detailed in these forums troublesome symptoms resulting from the drugs, and they were apt to report discontinuing the treatment or switching to a different drug in the same class. The findings are published online this week in the journal Pharmacoepidemiology and Drug Safety. With 2.5 million breast cancer survivors living in the United States today – the largest group of cancer survivors – researchers say the findings have broad implications for physician communication with patients about these issues to help to promote proper adherence and inform patient-to-patient discussion online. http://medicalxpress.com/news/2013-01-breast-cancer-message-boards-frequent.html Cancer Wed, 16 Jan 2013 09:45:28 EST news277551921 The American Society of Clinical Oncology (ASCO) has just released its annual report on the top cancer advances of the year. Clinical Cancer Advances 2012: ASCO's Annual Report on Progress Against Cancer, highlights major achievements in precision medicine, cancer screening and overcoming treatment resistance. http://medicalxpress.com/news/2012-12-american-society-clinical-oncology-issues.html Cancer Mon, 03 Dec 2012 16:00:12 EST news273757673 Cancer is a complex disease and only thanks to advances in genomic techniques have researchers begun to understand, at a cellular and molecular level, the mechanisms which are disrupted in cancer cells. This knowledge is a key prerequisite for developing effective treatment strategies. http://medicalxpress.com/news/2012-11-genome-packaging-key-breast-cancer.html Cancer Thu, 22 Nov 2012 10:25:38 EST news272802331 An oral green tea extract, Polyphenon E, appears to inhibit vascular endothelial growth factor and hepatocyte growth factor, both of which promote tumor cell growth, migration and invasion. http://medicalxpress.com/news/2012-10-mechanisms-action-green-tea-breast.html Cancer Thu, 18 Oct 2012 15:00:17 EST news269786109 Blood hormone tests can predict a woman's risk for developing postmenopausal breast cancer for up to 20 years, according to a study led by Xuehong Zhang, MD, Channing Division of Network Medicine, Brigham and Women's Hospital (BWH) Department of Medicine. http://medicalxpress.com/news/2012-10-blood-hormone-long-term-breast-cancer.html Cancer Thu, 18 Oct 2012 15:00:01 EST news269786031 Human epidermal growth factor (HER2) positive breast cancers are often treated with the same therapy regardless of hormone receptor status. New research published in BioMed Central's open access journal Breast Cancer Research shows that women whose HER2 positive cancer was also hormone (estrogen and progesterone) receptor (HR) negative had an increased risk of early death, and that their cancer was less likely to recur in bone than those whose cancer retained hormone sensitivity. http://medicalxpress.com/news/2012-10-breast-cancer-recurrence-hormone-receptor.html Cancer Mon, 01 Oct 2012 02:26:55 EST news268277209 Regular mammography screening can help narrow the breast cancer gap between black and white women, according to a retrospective study published in Breast Cancer Research and Treatment in August. http://medicalxpress.com/news/2012-09-disparity-breast-cancer-black-white.html Cancer Tue, 25 Sep 2012 15:24:06 EST news267805439 A large study in people at risk of diabetes has found a direct association between the presence of a small genetic alteration in a hormone receptor and increased body fat and insulin resistance. The results, to be presented Tuesday at The Endocrine Society's 94th Annual Meeting in Houston, suggest an adverse role for a previously described genetic variant, the BclI polymorphism. http://medicalxpress.com/news/2012-06-genetic-variant-linked-obesity-insulin.html Genetics Tue, 26 Jun 2012 14:30:01 EST news259925896 (HealthDay) -- From 2006 to 2008, the use of gene expression profile (GEP) testing increased, correlating with a decrease in the percentage of women with hormone receptor (HR)-positive breast cancer receiving adjuvant chemotherapy, according to a study published online May 14 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-05-gene-profile-breast-cancer.html Cancer Fri, 18 May 2012 04:30:01 EST news256532228 American and Spanish researchers have found potential ways for doctors to improve the treatment of hormone receptor-positive breast cancer even if they lack access to costly multi-gene tests, as they report at the 4th IMPAKT Breast Cancer Conference. http://medicalxpress.com/news/2012-05-progesterone-receptor-hormone-receptor-positive-cancer.html Cancer Thu, 03 May 2012 11:30:03 EST news255261199 Four proteins involved in translation, the final step of general protein production, are associated with poor prognosis in hormone-receptor-positive breast cancer when they are dysregulated, researchers reported at the AACR Annual Meeting 2012. http://medicalxpress.com/news/2012-04-pi3kmtor-pathway-proteins-tied-poor.html Cancer Sun, 01 Apr 2012 12:32:10 EST news252502306 Two studies published March 6 in the Journal of the National Cancer Institute provide insights about the CYP2D6 genotype in postmenopausal breast cancer patients and represent a major step forward in understanding the usefulness of CYP2D6 testing for deciding whether or not a patient should receive adjuvant tamoxifen for treatment of early-stage breast cancer. Both studies found that CYP2D6 genotypes that were indicative of reduced activity of enzymes that metabolize tamoxifen did not predict clinical responsiveness to adjuvant tamoxifen therapy among postmenopausal women with early-stage breast cancer. One study also found that CYP2D6 genotypes of reduced enzyme activity were not linked with fewer tamoxifen-induced hot flushes in patients. http://medicalxpress.com/news/2012-03-cyp2d6-genotype-tamoxifen-benefit.html Cancer Tue, 06 Mar 2012 16:00:07 EST news250263753 A leaky gut may be the root of some cancers forming in the rest of the body, a new study published online Feb. 21 in PLoS ONE by Thomas Jefferson University researchers suggests. http://medicalxpress.com/news/2012-02-stronger-intestinal-barrier-cancer-rest.html Immunology Tue, 21 Feb 2012 17:00:24 EST news249053644 Among postmenopausal women with hormone receptor-positive breast cancer, increasing age was associated with a higher risk of death from breast cancer, according to a study in the February 8 issue of JAMA. http://medicalxpress.com/news/2012-02-death-breast-cancer-higher-older.html Cancer Tue, 07 Feb 2012 16:29:01 EST news247854530 Post-menopausal women with hormone receptor-positive metastatic breast cancer may have a new treatment option that could lengthen their lives, according to results of a study by the SWOG clinical trials network that were presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium. http://medicalxpress.com/news/2011-12-anti-estrogen-combo-drug-hormone-sensitive-breast.html Cancer Wed, 07 Dec 2011 10:26:21 EST news242475965 Stockholm, Sweden: Women diagnosed with breast cancer late in life are at greater risk of dying from the disease than younger patients, assuming they survive other age-related conditions, according to a study to be presented at the 2011 European Multidisciplinary Cancer Congress on Saturday. The results point to shortcomings in patient care for elderly women as well as differences in the progress of the disease. http://medicalxpress.com/news/2011-09-elderly-breast-cancer-patients-treatment.html Cancer Thu, 22 Sep 2011 18:38:34 EST news235935491 The hormone receptor guanylyl cyclase C (GCC) has been established as a suppressor of colorectal cancer tumors, but new evidence from Thomas Jefferson University suggests it may also help fight one of the country's biggest pandemics: obesity. http://medicalxpress.com/news/2011-08-tumor-suppressor-obesity.html Medical research Thu, 25 Aug 2011 12:56:55 EST news233495785 Amid the controversy surrounding the Food and Drug Administration's ruling that Avastin should no longer be used to treat metastatic breast cancer, a new multinational Phase III clinical trial shows that Avastin significantly increased tumor response rates in breast cancer patients when given before surgery. http://medicalxpress.com/news/2011-08-clinical-trial-benefit-adding-avastin.html Cancer Tue, 23 Aug 2011 12:47:04 EST news233321197 African-American women are at higher risk for hormone receptor-negative breast cancer, one of the most difficult subtypes to treat, but this risk could be ameliorated somewhat by breast-feeding their children. http://medicalxpress.com/news/2011-08-childbearing-hormone-receptor-negative-breast-cancer.html Cancer Tue, 16 Aug 2011 13:55:15 EST news232721679 The use of trastuzumab, chemotherapy and surgery among women with HER2-positive metastatic breast cancer significantly improved survival from the time central nervous system metastases were diagnosed. http://medicalxpress.com/news/2011-07-trastuzumab-chemotherapy-survival-her2-postive-breast.html Cancer Mon, 18 Jul 2011 03:55:34 EST news230179836 Cancer researchers at the Kimmel Cancer Center at Jefferson and an international team of collaborators have discovered a biomarker in breast cancer that may help identify which women will respond to anti-estrogen therapy. http://medicalxpress.com/news/2011-05-marker-breast-cancer-patients-tamoxifen.html Cancer Wed, 18 May 2011 10:12:32 EST news224932338 Two multi-gene tests designed to predict the risk of disease progression and response to chemotherapy in breast cancer produce broadly similar results for high- and low-risk patients, but do not always agree in their predictions for those at intermediate risk, a new analysis shows. http://medicalxpress.com/news/2011-05-breast-cancer-multi-gene.html Cancer Thu, 05 May 2011 09:56:03 EST news223808141 Drugs known as thiazolidinediones, or TZDs for short, are widely used in diabetes treatment, but they come with a downside. The drugs have effects on the kidneys that lead to fluid retention as the volume of plasma in the bloodstream expands. http://medicalxpress.com/news/2011-05-popular-diabetes-drugs-cardiovascular-side_1.html Medical research Tue, 03 May 2011 12:17:37 EST news223643824