http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. NIH-supported scientists used lab-grown human lung cells to study the cells' response to infection by a novel human coronavirus (called nCoV) and compiled information about which genes are significantly disrupted in early and late stages of infection. The information about host response to nCoV allowed the researchers to predict drugs that might be used to inhibit either the virus itself or the deleterious responses that host cells make in reaction to infection. Since nCoV was recognized in 2012, 17 confirmed cases and 11 deaths have been reported—a high fatality rate that is spurring urgent research efforts to better understand the virus and its effects. http://medicalxpress.com/news/2013-04-cell-response-coronavirus-unveils-paths.html Diseases, Conditions, Syndromes Tue, 30 Apr 2013 13:33:04 EST news286547577 (Medical Xpress)—Tumours need a steady supply of sufficient nutrients to be able to grow. In order to secure the nutrient availability, they secrete messenger compounds to stimulate neighbouring blood vessels to proliferate and sprout. Scientists from the Max Planck Institute for Neurological Research in Cologne, Germany, have now identified a new positive feedback loop involving the Vascular Endothelial Growth Factor (VEGF) and its receptor 'VEGFR-2' in human lung adenocarcinoma. http://medicalxpress.com/news/2013-03-fasting-tumour-cells.html Cancer Fri, 15 Mar 2013 07:25:31 EST news282551120 In a London ceremony today, Wyss Founding Director Don Ingber, M.D., Ph.D., received the NC3Rs 3Rs Prize from the UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) for his innovative Lung-on-a-Chip—a microdevice lined by human cells that recapitulates complex functions of the living lung. http://medicalxpress.com/news/2013-02-lung-on-a-chip-prize-potentially-animal.html Medical research Tue, 26 Feb 2013 11:38:21 EST news281101092 The new coronavirus that has emerged in the Middle East is well-adapted to infecting humans but could potentially be treated with immunotherapy, according to a study to be published on February 19 in mBio, the online open-access journal of the American Society for Microbiology. The study indicates that the virus HCoV-EMC can penetrate the lining of the passageways in the lung and evade the innate immune system as easily as a cold virus can, signs that HCoV-EMC is well-equipped for infecting human cells. The study also reveals that the virus is susceptible to treatment with interferons, components of the immune system that have been used successfully to treat other viral diseases, opening a possible mode of treatment in the event of a large-scale outbreak. http://medicalxpress.com/news/2013-02-coronavirus-well-adapted-humans-susceptible-immunotherapy.html Diseases, Conditions, Syndromes Tue, 19 Feb 2013 04:20:01 EST news280468360 The SARS epidemic of 2002-2003 was short-lived, but a novel type of human coronavirus that is alarming public health authorities can infect cells from humans and bats alike, a fact that could make the animals a continuing source of infection, according to a study to be published in in mBio, the online open-access journal of the American Society for Microbiology, on December 11. http://medicalxpress.com/news/2012-12-coronavirus-potential-hosts-animals-humans.html Diseases, Conditions, Syndromes Tue, 11 Dec 2012 00:00:06 EST news274382432 (HealthDay)—A new study that helps explain how human airways rid the lungs of mucus could give insights into asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD), researchers say. http://medicalxpress.com/news/2012-08-human-lungs-intruders.html Medical research Thu, 23 Aug 2012 15:30:02 EST news264951382 (Medical Xpress)—When you are hit with the flu, you know it immediately—fever, chills, sore throat, aching muscles, fatigue. This is your body mounting an immune response to the invading virus. But less is known about what is happening on the molecular level. http://medicalxpress.com/news/2012-08-scientists-ways-influenza-virus-host.html Medical research Thu, 23 Aug 2012 13:00:01 EST news264945204 (HealthDay) -- Researchers have uncovered the first evidence that the adult human lung is capable of growing back -- at least in part -- after being surgically removed. http://medicalxpress.com/news/2012-07-evidence-adult-human-lungs-regrow.html Medical research Thu, 19 Jul 2012 05:30:01 EST news261892800 Overactive epidermal growth factor receptor (EGFR) signaling has been linked to the development of cancer. Several drug therapies have been developed to treat these EGFR-associated cancers; however, many patients have developed resistance to these drugs and are therefore no longer responsive to drug treatment. http://medicalxpress.com/news/2012-06-combination-drug-resistance-cancer.html Cancer Fri, 01 Jun 2012 13:01:11 EST news257774460 (Medical Xpress) -- Innovative technology being pioneered at Cardiff to speed up the discovery of new drugs to tackle lung diseases could also dramatically reduce testing on animals. http://medicalxpress.com/news/2011-11-breakthrough-drug-discovery.html Medical research Fri, 25 Nov 2011 06:10:42 EST news241423834 Cigarette smoke exposure fundamentally alters airway tissue from people with chronic obstructive pulmonary disease (COPD) at the cellular level, laying the groundwork for airway thickening and even precipitating precancerous changes in cell proliferation that may be self-perpetuating long after cigarette smoke exposure ends, according to Australian researchers. http://medicalxpress.com/news/2011-07-mechanism-underlying-copd-disease-persistence.html Diseases, Conditions, Syndromes Wed, 27 Jul 2011 10:50:01 EST news230981716