http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Heart disease and approximately half of all strokes are the results of advanced atherosclerosis with damaged endothelium, the inner lining of blood vessels. In 2009, the direct and indirect annual cost of heart disease and stroke was approximately $312.6 billion. Projections are for the total cost of heart disease to increase from $523 to $1.126 billion from 2013 to 2030. And by 2030, it is expected that there will be more than 148 million of the US population would have heart disease. Development of new technologies for assessing and treating endothelium damage will help reduce that financial burden as reduce the human health burden resulting from atherosclerosis. http://medicalxpress.com/news/2013-04-therapies-endothelial-atherosclerotic-plaques.html Cardiology Sun, 21 Apr 2013 19:01:28 EST news285789678 (Medical Xpress)—Last week, the common antibiotic Zithromax received a new warning label from the U.S. Food and Drug Administration indicating it could cause dangerous arrhythmias in people with pre-existing heart conditions. Today, researchers at the Stanford University School of Medicine describe a "clinical trial in a dish" using patient-specific induced pluripotent stem, or iPS, cells to predict whether a drug will dangerously affect the heart's function. The technique may be more accurate than the current in vitro drug-safety screening assays used by pharmaceutical companies, say the researchers, and may better protect patients from deadly side effects of common medications. http://medicalxpress.com/news/2013-03-clinical-trials-dish-reliable-standard.html Medical research Fri, 22 Mar 2013 11:40:03 EST news283165743 The over-the-counter anti-inflammatory drug naproxen may also exhibit antiviral activity against influenza A virus, according to a team of French scientists. The finding, the result of a structure-based investigation, is published online ahead of print in the journal Antimicrobial Agents and Chemotherapy. http://medicalxpress.com/news/2013-03-pain-reliever-naproxen-anti-viral-flu.html Medications Thu, 21 Mar 2013 14:44:02 EST news283095833 (Medical Xpress)—A team of researchers at Indiana University's School of Medicine has found that giving meloxicam, a non-steroidal anti-inflammatory drug (NSAID), to people and baboons boosts the number of haematopoietic stem cells that enter the blood stream from bone marrow. This, the team writes in their paper they've had published in the journal Nature, may help cancer patients recover their ability to create new blood cells following chemotherapy. http://medicalxpress.com/news/2013-03-nsaids-stem-cells-bloodstream-prior.html Medical research Thu, 14 Mar 2013 08:37:33 EST news282469042 A single dose of an investigational anti-inflammatory drug, inclacumab, reduced damage to heart tissue during angioplasty in a study presented today at the American College of Cardiology's 62nd Annual Scientific Session. http://medicalxpress.com/news/2013-03-drug-heart-angioplasty.html Cardiology Tue, 12 Mar 2013 10:36:46 EST news282303358 A single dose of an investigational anti-inflammatory drug called inclacumab considerably reduces damage to heart muscle during angioplasty (the opening of a blocked artery), according to a recent international clinical trial spearheaded by Dr. Jean-Claude Tardif, Director of the Research Centre at the Montreal Heart Institute, affiliated with the University of Montreal. Presented today in San Francisco at the prestigious American cardiology conference, these findings show great promise. http://medicalxpress.com/news/2013-03-drug-inclacumab-heart.html Cardiology Sun, 10 Mar 2013 14:30:01 EST news282138621 Phenylbutazone, a painkiller for horses, can cause blood disorders in humans but at doses much higher than any one person is likely to ingest from eating horsemeat. http://medicalxpress.com/news/2013-02-facts-bute-pain-drug-horsemeat.html Other Thu, 14 Feb 2013 12:00:01 EST news280064923 Cancer researchers are increasingly aware that in addition to genetic mutations in a cancer itself, characteristics of the surrounding tissue can promote or suppress tumor growth. One of these important tissue characteristics is inflammation – most cancers prosper in and attach to inflamed tissue and so many cancers have developed ways to create it. http://medicalxpress.com/news/2013-01-body-ibuprofen-sparc-inflammation-bladder.html Cancer Wed, 16 Jan 2013 12:00:01 EST news277556125 (AP)—The Supreme Court will decide whether generic drug manufacturers can be held responsible in state courts for possible design defects that are in the brand-name medicine they are copying. http://medicalxpress.com/news/2012-11-court-makers-sued-drug-flaws.html Medications Fri, 30 Nov 2012 15:58:26 EST news273513479 If a medical study seems too good to be true, it probably is, according to a new analysis. http://medicalxpress.com/news/2012-10-medical-results-false.html Cancer Wed, 24 Oct 2012 16:20:01 EST news270314004 Dr. Anglea Wandinger-Ness and Dr. Laurie Hudson were awarded a Provocative Questions grant to investigate the use of R-ketorolac against ovarian cancer. Ketorolac is an NSAID that the FDA approved for human use in 1991. They are investigating their hypothesis that R-ketorolac, and not S-ketorolac, acts on GTPases in the cell to control cell adhesion and growth in ovarian cancer cells. http://medicalxpress.com/news/2012-09-drug.html Medications Thu, 27 Sep 2012 13:44:25 EST news267972257 In the first clinical trial to demonstrate an effective treatment for constant, disabling cough among people with idiopathic pulmonary fibrosis (IPF), researchers at the Johns Hopkins University School of Medicine found that taking thalidomide significantly reduced the cough and improved quality of life. http://medicalxpress.com/news/2012-09-thalidomide-relieves-disabling-people-deadly.html Diseases, Conditions, Syndromes Mon, 17 Sep 2012 17:00:01 EST news267098688 (HealthDay)—Two new studies paint a complex portrait of aspirin's impact on cancer risk and mortality, with one suggesting the drug may lower the risk of dying from prostate cancer and the other seeing no significant drop in the risk for developing breast cancer. http://medicalxpress.com/news/2012-08-daily-aspirin-prostate-cancer-breast.html Cancer Mon, 27 Aug 2012 17:20:02 EST news265303971 An international multi-site trial has launched to determine whether a common anti-inflammatory drug can reduce heart attacks, strokes, and deaths due to cardiovascular disease in people at high risk for them. This study is being supported by the National Heart, Lung, and Blood Institute (NHLBI), a part of the National Institutes of Health. http://medicalxpress.com/news/2012-08-nih-trial-anti-inflammatory-treatment-heart.html Cardiology Wed, 22 Aug 2012 02:50:01 EST news264821847 (HealthDay) -- For patients with type 2 diabetes (T2D), treatment with salsalate does not improve endothelial function as measured by flow-mediated, endothelium-dependent dilation (FMD), although it is associated with lower glycated hemoglobin (HbA1c) levels and markers of inflammation, according to a study presented at the American Diabetes Association's 72nd Scientific Sessions, held from June 8 to 12 in Philadelphia. http://medicalxpress.com/news/2012-06-ada-salsalate-doesnt-endothelial-function.html Diseases, Conditions, Syndromes Tue, 12 Jun 2012 13:30:01 EST news258723935 (Phys.org) -- Researchers in Canada, Scotland and Australia have discovered that salicylate, the active ingredient in aspirin, directly increases the activity of the protein AMPK (AMP-activated protein kinase), a key player in regulating cell growth and metabolism. AMPK which is considered a cellular fuel-gauge is switched on by exercise and the commonly used anti-diabetic medication metformin. http://medicalxpress.com/news/2012-04-potential-drug.html Medications Thu, 19 Apr 2012 14:32:47 EST news254064740 Scientists at Emory University School of Medicine have identified a new group of compounds that may protect brain cells from inflammation linked to seizures and neurodegenerative diseases. http://medicalxpress.com/news/2012-02-class-potential-drugs-inhibits-inflammation.html Neuroscience Tue, 14 Feb 2012 11:14:10 EST news248440412 A new study in Nature Medicine describes how different types of immune system T-cells alternately discourage and encourage stem cells to regrow bone and tissue, bringing into sharp focus the importance of the transplant recipient's immune system in stem cell regeneration. http://medicalxpress.com/news/2011-11-recipient-immune-stem-cell-regeneration.html Medical research Sun, 20 Nov 2011 13:00:22 EST news241013089 A new study in the Journal of Bone and Joint Surgery (JBJS) found that patients with herniated lumbar disc symptoms were significantly worse if the patients had symptoms for more than six months prior to treatment, compared to those who had symptoms for six months or less. Symptoms included pain, function, general health, work status and patient satisfaction. http://medicalxpress.com/news/2011-10-surgical-treatment-months-lumbar-disc.html Diseases, Conditions, Syndromes Tue, 25 Oct 2011 13:30:48 EST news238768237 Postmenopausal women who reported having used nonsteroidal anti-inflammatory drugs for at least 10 years at the time of enrollment in the Women's Health Initiative study had a lower risk for death from colorectal cancer compared with women who reported no use of these drugs at enrollment, according to data presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011. http://medicalxpress.com/news/2011-10-nsaid-colorectal-cancer-mortality-postmenopausal.html Cancer Mon, 24 Oct 2011 04:27:49 EST news238649261 Taking the new generation anti-inflammatory drug natalizumab for two years lowers the number of remitting multiple sclerosis patients who experience relapses and progression of disability. This is the main finding of a systematic review published in the latest edition of The Cochrane Library. http://medicalxpress.com/news/2011-10-remitting-multiple-sclerosis-natalizumab-relapses.html Diseases, Conditions, Syndromes Wed, 05 Oct 2011 04:18:58 EST news237007118 Several clinical studies have shown that taking the anti-inflammatory drug celecoxib can reduce the risk of developing polyps that lead to colon cancers, at the cost of increasing the risk of heart disease. But what if this tradeoff was not necessary? http://medicalxpress.com/news/2011-09-cancer-drug-heart-disease.html Cancer Tue, 13 Sep 2011 11:50:03 EST news235131850 A new anti-inflammatory drug used by patients with type 2 diabetes improved their kidney function during a year-long study involving researchers from UT Southwestern Medical Center. http://medicalxpress.com/news/2011-06-drug-kidney-function-diabetics.html Diseases, Conditions, Syndromes Fri, 24 Jun 2011 11:10:31 EST news228132609 A new drug to treat potentially fatal lung injuries caused by ventilators in hospital intensive care units is being developed by Flinders University researchers. http://medicalxpress.com/news/2011-06-drug-life-intensive.html Medical research Tue, 07 Jun 2011 12:06:04 EST news226667146 The anti-inflammatory drug celecoxib may be a useful additional treatment for people with breast cancer, Dutch researchers report at the IMPAKT Breast Cancer Conference in Brussels. http://medicalxpress.com/news/2011-05-anti-inflammatory-drug-breast-cancer.html Cancer Thu, 05 May 2011 10:01:54 EST news223808489