http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Obese older adults can reduce their chance of developing the metabolic syndrome by losing weight through dieting alone, but adding exercise to a weight loss program has even more benefit, a new study finds. The results, to be presented at The Endocrine Society's 94th Annual Meeting in Houston, show that a combination of diet-induced weight loss and frequent exercise almost doubled the improvement in insulin sensitivity compared with dieting alone. http://medicalxpress.com/news/2012-06-diet-insulin-sensitivity.html Diabetes Mon, 25 Jun 2012 10:16:25 EST news259838164 (HealthDay) -- A widely prescribed drug, metformin, may lower the risk of invasive breast cancer in postmenopausal women with diabetes, a new study indicates. http://medicalxpress.com/news/2012-06-diabetes-drug-metformin-breast-cancer.html Cancer Mon, 11 Jun 2012 18:10:01 EST news258653386 Drugs for type 2 diabetes can contribute to weight gain, bone fractures and cardiovascular problems, but in mice, an investigational drug appears to improve insulin sensitivity without those troublesome side effects, researchers at Washington University School of Medicine in St. Louis have shown. http://medicalxpress.com/news/2012-06-diabetes-drug-side-effects.html Medical research Mon, 04 Jun 2012 17:51:39 EST news258051090 In recent years, a growing body of evidence has linked inflammation to the development of insulin resistance. In insulin resistance, the hormone insulin is less effective in promoting glucose uptake from the bloodstream into other tissues. Obesity is a major factor that contributes to insulin resistance, which can eventually lead to type 2 diabetes. Previous studies have shown that proinflammatory molecules found in fat tissue decreases sensitivity of tissues to insulin. http://medicalxpress.com/news/2012-06-obesity-induced-insulin-sensitivity.html Overweight and Obesity Fri, 01 Jun 2012 13:05:49 EST news257774686 (HealthDay) -- For women without diabetes and with operable breast cancer, administration of metformin prior to surgery does not significantly affect the proliferative marker Ki-67 overall, but drug effects are observed according to homeostasis model assessment (HOMA), particularly in luminal B tumors, according to a study published online May 7 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-05-metformin-dual-effect-breast-cancer.html Cancer Wed, 09 May 2012 15:00:01 EST news255786992 (HealthDay) -- Levels of some amino acids are associated with glycemia and insulin resistance and predict the development of type 2 diabetes in men, according to a study published online May 2 in Diabetes. http://medicalxpress.com/news/2012-05-amino-acid-linked-diabetes.html Diabetes Wed, 09 May 2012 14:30:01 EST news255786955 (HealthDay) -- Liver insulin resistance (IR) may be a significant indicator of cardiovascular disease (CVD) risk among men, and correlates more closely with risk factors than whole-body insulin sensitivity, according to a study published online April 5 in the Journal of Internal Medicine. http://medicalxpress.com/news/2012-04-liver-insulin-resistance-cardiac.html Cardiology Mon, 16 Apr 2012 17:50:01 EST news253816036 (Medical Xpress) -- Scientists used the ACE inhibitor captopril (CAP)—commonly used for the treatment of hypertension and cardiac conditions—and found that it can reduce the body weight of mice maintained on a high-fat diet. http://medicalxpress.com/news/2012-04-shown-reverse-obesity-body-fat.html Medical research Fri, 13 Apr 2012 09:22:40 EST news253527747 A class of compounds found in hops, the crop generally known for its role in beer production, reduces weight gain in obese and diabetic mice, according to a study published Mar. 28 in the open access journal PLoS ONE. http://medicalxpress.com/news/2012-03-compounds-health-obese-diabetic-mice.html Diabetes Wed, 28 Mar 2012 17:00:13 EST news252153740 (HealthDay) -- There is considerable evidence that calcium and vitamin D intake are influential in modulating energy metabolism in humans, according to a study published online March 2 in Obesity Reviews. http://medicalxpress.com/news/2012-03-calcium-vitamin-d-modulate-human.html Health Mon, 12 Mar 2012 14:30:01 EST news250779073 Intermittent exercise with and without low oxygen concentrations (or hypoxia) can improve insulin sensitivity in type 2 diabetics, however exercise while under hypoxic conditions provides greater improvements in glycemic control than intermittent exercise alone, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). http://medicalxpress.com/news/2012-02-intermittent-blood-glucose-diabetics.html Health Thu, 02 Feb 2012 07:50:01 EST news247390627 New research from Uppsala University shows that reduced insulin sensitivity is linked to smaller brain size and deteriorated language skills in seniors. The findings are now published in the scientific journal Diabetes Care. http://medicalxpress.com/news/2012-02-insulin-resistance-linked-brain-health.html Diseases, Conditions, Syndromes Wed, 01 Feb 2012 10:31:32 EST news247314682 UCLA researchers demonstrated that an over-the-counter dietary supplement may help inhibit development of insulin resistance and glucose intolerance, conditions that are involved in the development of Type 2 diabetes and metabolic syndrome, which affect millions worldwide. http://medicalxpress.com/news/2011-09-early-dietary-supplement-diabetes.html Diseases, Conditions, Syndromes Thu, 22 Sep 2011 17:38:02 EST news235931866 Cells in bone, fat and the pancreas appear to be talking to each other and one thing they likely are saying is, "Get moving." http://medicalxpress.com/news/2011-09-healthy-chatter-bone-fat-pancreatic.html Medical research Mon, 19 Sep 2011 11:31:35 EST news235650539 High levels of chocolate consumption might be associated with a one third reduction in the risk of developing heart disease, finds a study published in the British Medical Journal today. http://medicalxpress.com/news/2011-08-chocolate-linked-heart-health.html Cardiology Mon, 29 Aug 2011 08:48:57 EST news233826522 Research led by Dr. Melinda Sothern, Professor of Public Health and Jim Finks Endowed Chair in Health Promotion at LSU Health Sciences Center New Orleans, has found that obese 7-9-year-old children had nearly three times the liver fat and almost double the belly fat of their nonobese counterparts and that insulin resistance was more than double and insulin sensitivity less than half respectively. The study is the first to use a combination of advanced measurements in healthy obese and nonobese children in this age group prior to entering puberty. The findings are detailed in the journal, Obesity, online August 25, 2011. http://medicalxpress.com/news/2011-08-differences-metabolic-disease-markers-healthy.html Health Thu, 25 Aug 2011 10:36:27 EST news233487374 Research to be presented at the upcoming annual meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, may explain why some antipsychotic drugs can promote overeating, weight gain, and insulin resistance. http://medicalxpress.com/news/2011-07-metabolic-effects-antipsychotic-drugs.html Medical research Tue, 12 Jul 2011 05:14:38 EST news229666465 Poor maternal diet before conception can result in offspring with reduced birth weights and increased risk of developing type II diabetes and obesity. http://medicalxpress.com/news/2011-07-pre-pregnancy-diet-affects-health-future.html Health Sat, 02 Jul 2011 10:24:34 EST news228820840 A study led by researchers at the Joslin Diabetes Center suggests that adding the amino acid leucine to their diets may help those with pre-diabetes or metabolic syndrome. http://medicalxpress.com/news/2011-06-dietary-leucine-prediabetes-metabolic-syndrome.html Medical research Wed, 22 Jun 2011 17:30:01 EST news227982261 A little bitter with a little sweet, in the form of a nano-complex dietary supplement taken before meals, can result in a substantial reduction of fat and sugar absorption in the body, Hebrew University of Jerusalem and Harvard University researchers have found. http://medicalxpress.com/news/2011-05-pre-meal-dietary-supplement-fat-sugar.html Medical research Mon, 23 May 2011 09:47:30 EST news225362838 The road to type 2 diabetes is paved with insulin resistance, a condition often associated with obesity in which the hormone begins to fail at its job helping to convert sugars to energy. Researchers at Joslin Diabetes Center have now identified an enzyme called PKC-delta as an important molecular modifier for development of insulin resistance, diabetes and fatty liver in mice. They also have found evidence suggesting a similar role for the enzyme in humans, making PKC-delta a promising new target for drugs for diabetes and related ailments. http://medicalxpress.com/news/2011-05-tale-mice-major-factor-insulin.html Medical research Mon, 16 May 2011 12:41:45 EST news224768488 (PhysOrg.com) -- Despite promising findings in the laboratory, nutrition researchers at Washington University School of Medicine in St. Louis have found that ginseng does not improve insulin sensitivity in diabetics who are overweight. http://medicalxpress.com/news/2011-04-ginseng-doesnt-patients-early-diabetes.html Diseases, Conditions, Syndromes Tue, 19 Apr 2011 07:35:36 EST news222417317 Walking on a treadmill for one hour a day may slow the progression of nonalcoholic fatty liver disease in obese people with prediabetes by jump-starting their metabolism and slowing the oxidative damage wrought by the condition, say researchers at the Cleveland Clinic. A study of 15 obese people with nonalcoholic fatty liver disease revealed that the daily walks not only increase insulin sensitivity, but improve the liver's polyunsaturated lipid index (PUI), which is thought to be a marker of liver health. http://medicalxpress.com/news/2011-04-aerobic-nonalcoholic-fatty-liver-disease.html Diseases, Conditions, Syndromes Wed, 13 Apr 2011 13:03:27 EST news221918599