http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Two articles in BioMed Central's open access journal BMC Medicine by Geoff Wong, Trisha Greenhalgh and colleagues, propose publication guidelines for both realist synthesis and meta-narrative reviews. http://medicalxpress.com/news/2013-01-guidelines-systematic-bmc-medicine.html Other Mon, 28 Jan 2013 19:00:01 EST news278613264 (Medical Xpress)—At least one in five people in countries for which data are available were infected with influenza during the first year of the 2009 H1N1 pandemic, according to a new study. http://medicalxpress.com/news/2013-01-infected-flu-pandemic-international.html Diseases, Conditions, Syndromes Fri, 25 Jan 2013 09:25:58 EST news278328348 Scientists have long known that the human genome is incredibly complex. However, after almost 10 years of hard work, a team of more than 400 scientists at 32 research institutions worldwide has finally made serious headway in beginning to understand the structure, function and internal logic of the approximately 3.2 billion bases found within every cell of our body. http://medicalxpress.com/news/2013-01-staking-unknown-genomic-territory.html Genetics Fri, 04 Jan 2013 09:40:02 EST news276513381 (Medical Xpress)—A well-established family of drugs used to treat parasitic diseases is showing surprising potential as a therapy for tuberculosis (TB), according to new research from University of British Columbia microbiologists. http://medicalxpress.com/news/2012-11-repurposed-anti-parasite-drug-tb-treatment.html Diseases, Conditions, Syndromes Fri, 23 Nov 2012 07:58:29 EST news272879872 With today's modern medicine, misdiagnoses may be unexpected and surprising. But when symptoms of an unknown and uncommon illness mimic a number of other conditions, it can be difficult for medical professionals to properly diagnose and treat patients. That's why four leading allergy/immunology organizations have announced the release of a report to help set a new standard for a commonly misdiagnosed, under-recognized and under treated condition known as angioedema, the rapid swelling of deep layers of skin and tissue. http://medicalxpress.com/news/2012-11-aims-medical-misdiagnoses-treatment.html Immunology Fri, 09 Nov 2012 03:40:01 EST news271654300 Scientists from the University of Sheffield have unlocked one of the secrets to DNA repair—helping doctors identify DNA base damage and a patient's susceptibility to certain types of cancer. http://medicalxpress.com/news/2012-10-secrets-dna.html Cancer Wed, 31 Oct 2012 17:18:40 EST news270922713 Three thousand new cases of Mantle Cell Lymphoma (MCL), a form of blood cancer, appear in the United States each year. With a median survival span of only five to seven years, according to the Leukemia and Lymphoma Society, this disease is devastating, and new therapies are sorely needed. http://medicalxpress.com/news/2012-10-rna-based-therapy-incurable-blood-cancer.html Cancer Wed, 10 Oct 2012 13:02:08 EST news269092903 Public health 'superheroes' are needed to help tackle the growing challenges posed by obesity, alcohol, smoking and other public health threats, according to new research published today. http://medicalxpress.com/news/2012-10-superheroes-tackle-timebomb-health.html Health Sat, 06 Oct 2012 07:31:33 EST news268727479 A whole-genome scan to identify large-scale chromosomal damage can help doctors choose the best treatment option for children with neuroblastoma, one of the most common types of childhood cancer, finds an international collaboration jointly led by The Institute of Cancer Research, London. http://medicalxpress.com/news/2012-09-whole-genome-scan-treatment-childhood-cancer.html Cancer Fri, 14 Sep 2012 10:21:24 EST news266836870 An important breakthrough could help in the fight against myotonic dystrophy. The discovery, recently published in the prestigious scientific journal Cell, results from an international collaboration between researchers at the IRCM, the Massachusetts Institute of Technology (MIT), the University of Southern California and Illumina. Their findings could lead to a better understanding of the causes of this disease. http://medicalxpress.com/news/2012-09-implications-pathogenesis-myotonic-dystrophy.html Medical research Wed, 12 Sep 2012 10:45:41 EST news266665530 With widespread hunger continuing to haunt developing nations, and obesity fast becoming a global epidemic, any number of efforts on the parts of governments, scientists, non-profit organizations and the business world have taken aim at these twin nutrition-related crises. But all of these efforts have failed to make a large dent in the problems, and now an unusual international collaboration of researchers is explaining why. http://medicalxpress.com/news/2012-07-anti-hunger-anti-obesity-fall-short.html Overweight and Obesity Mon, 23 Jul 2012 15:00:11 EST news262262102 (Medical Xpress) -- Adrenocortical cancer is an uncommon form of cancer that is often fatal. For the first time, a large-scale randomized treatment study has now been carried out. The study is being published in the prestigious New England Journal of Medicine and constitutes an important and long-awaited platform for continued research. http://medicalxpress.com/news/2012-06-important-adrenal-cortex-cancer.html Cancer Mon, 11 Jun 2012 06:03:33 EST news258613389 Patients with infective endocarditis involving implanted cardiac devices experience a high rate of complications such as valve infections, heart failure, and persistent bacteremia, and high in-hospital and 1-year mortality rates, particularly if there is valve involvement, according to a study in the April 25 issue of JAMA. http://medicalxpress.com/news/2012-04-heart-infection-involving-icd-high.html Cardiology Tue, 24 Apr 2012 16:44:41 EST news254504670 An international study found that bone marrow transplants are not the best option for some young patients with acute lymphoblastic leukemia (ALL) who fail to attain clinical remission after the initial weeks of intense chemotherapy known as induction therapy. http://medicalxpress.com/news/2012-04-chemotherapy-life-saving-leukemia-patients-induction.html Cancer Wed, 11 Apr 2012 17:00:11 EST news253377835 Three newly confirmed lupus genes are opening new avenues of research at the Oklahoma Medical Research Foundation. http://medicalxpress.com/news/2012-03-lupus-genes.html Genetics Thu, 29 Mar 2012 12:00:05 EST news252239914 (Medical Xpress) -- Helene Intraub, professor of psychology at the University of Delaware, and then-undergraduate researcher Mike Richardson first published their paper on the phenomenon of "boundary extension" in 1989, describing a phenomenon that surprised many observers. http://medicalxpress.com/news/2012-03-explores-common-visual-error-boundary.html Psychology & Psychiatry Fri, 09 Mar 2012 09:27:00 EST news250507590 Persistent protein expression may explain why tumors return after therapy in glioblastoma patients, according to a study published on March 5th in the Journal of Experimental Medicine. http://medicalxpress.com/news/2012-03-culprit-brain-tumor-resistance-therapy.html Cancer Mon, 05 Mar 2012 12:00:03 EST news250165773 Scientists at King's College London and the National Diabetes Centre (Sri Lanka) have found evidence of a high number of risk factors for type 2 diabetes among the young urban population in Sri Lanka. The study is the first large-scale investigation into diabetes risk among children and young people in South Asia, and provides further evidence that the region is rapidly becoming a hotspot in the growing international diabetes epidemic. http://medicalxpress.com/news/2012-02-diabetes-factors-young-sri-lankans.html Diabetes Tue, 14 Feb 2012 09:40:32 EST news248434824 The genetic predisposition to obesity due to the 'fat mass and obesity associated' (FTO) gene can be substantially reduced by living a physically active lifestyle according to new research by a large international collaboration, led by Ruth Loos from the Medical Research Council Epidemiology Unit, in Cambridge, UK, and published in this week's PLoS Medicine. The researchers found that the effect of the FTO gene on obesity risk is nearly 30% weaker among physically active than in physically inactive adults. http://medicalxpress.com/news/2011-11-physical-effect-obesity-gene.html Health Tue, 01 Nov 2011 17:45:43 EST news239388293 An international collaboration of scientists, including researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a part of the National Institutes of Health, has identified a genetic mutation that causes a rare childhood disease characterized predominantly by inflammation and fat loss. The research suggests that the disorder, named chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE), actually represents a spectrum of diseases that have been described in the literature under a variety of names. More importantly, since no effective treatment for this disease currently exists, the findings may have uncovered a possible target for future treatments. http://medicalxpress.com/news/2011-10-scientists-link-spectrum-childhood-diseases.html Diseases, Conditions, Syndromes Mon, 31 Oct 2011 11:33:22 EST news239279590 HIV infection is commonly associated with other sexual infections, such as herpes simplex virus (HSV). Infection with HSV facilitates the risk of HIV infection and negatively impacts the clinical course of HIV disease. Therefore, it would be highly beneficial to identify multi-faceted microbicide compounds that are efficient against HIV-1 and other sexually transmitted infections. http://medicalxpress.com/news/2011-10-duty-anti-hiv-topical-gel-herpes.html HIV & AIDS Wed, 19 Oct 2011 12:36:08 EST news238246558 Genetics play an important role in the variation in, and risk of, low testosterone concentrations in men. A study by the CHARGE Sex Hormone Consortium, published in the open-access journal PLoS Genetics on Thursday, 6th October, is the first genome-wide association study to examine the effects of common genetic variants on serum testosterone concentrations in men. http://medicalxpress.com/news/2011-10-testosterone-men-affected-genetic-makeup.html Genetics Thu, 06 Oct 2011 17:00:01 EST news237129242 A new genetic defect that predisposes people to acute myeloid leukemia and myelodysplasia has been discovered. The mutations were found in the GATA2 gene. Among its several regulatory roles, the gene acts as a master control during the transition of primitive blood-forming cells into white blood cells. http://medicalxpress.com/news/2011-09-gene-defect-predisposes-people-leukemia.html Genetics Sun, 04 Sep 2011 13:01:42 EST news234359162 Innovative UK technology is contributing to the development of a revolutionary digital stethoscope that could make it easier for GPs to spot the first signs of heart disease. http://medicalxpress.com/news/2011-06-synchronization-technology-key-earlier-diagnosis.html Cardiology Thu, 02 Jun 2011 10:12:35 EST news226228344