http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. New Johns Hopkins research showing a more than four-fold increase in the incidence of breast cancer in women with neurofibromatosis-1 (NF1) adds to growing evidence that women with this rare genetic disorder may benefit from early breast cancer screening with mammograms beginning at age 40, and manual breast exams as early as adolescence. http://medicalxpress.com/news/2012-11-gene-tumor-disorder-linked-breast.html Cancer Tue, 27 Nov 2012 04:49:49 EST news273214178 Researchers at Moffitt Cancer Center working with colleagues at three other institutions have validated a link between a rare genetic variant and the risk of glioma, the most common and lethal type of brain tumor. The validation study also uncovered an association between the same rare genetic variant and improved rates of survival for patients with glioma. http://medicalxpress.com/news/2012-07-validates-rare-genetic-variant-glioma.html Genetics Mon, 02 Jul 2012 17:26:18 EST news260468773 Advanced high-speed gene-sequencing has been used in the clinical setting to find diagnoses for seven children out of a dozen who were experiencing developmental delays and congenital abnormalities for mysterious reasons. http://medicalxpress.com/news/2012-05-sequencing-clinical-diagnosis.html Pediatrics Tue, 08 May 2012 00:20:01 EST news255629098 Ohio State University researchers have discovered a hereditary cancer syndrome that predisposes certain people to a melanoma of the eye, along with lung cancer, brain cancer and possibly other types of cancer. http://medicalxpress.com/news/2011-12-hereditary-predisposition-melanoma-eye.html Ophthalmology Thu, 15 Dec 2011 16:18:14 EST news243188281 In the largest study of its kind to date, Stanford University School of Medicine researchers have shown that women related to a patient with a breast cancer caused by a hereditary mutation -- but who don't have the mutation themselves -- have no higher risk of getting cancer than relatives of patients with other types of breast cancer. The multinational, population-based study involving more than 3,000 families settles a controversy that arose four years ago when a paper hinted that a familial BRCA mutation in and of itself was a risk factor. http://medicalxpress.com/news/2011-10-higher-breast-cancer-women-dont.html Cancer Mon, 31 Oct 2011 16:00:03 EST news239289107 Chromosomal abnormalities linked to intellectual disability can be traced back to the father, particularly those who are older when the child is conceived, finds research published online in the Journal of Medical Genetics. http://medicalxpress.com/news/2011-10-faulty-intellectual-disability-genes-linked.html Genetics Mon, 03 Oct 2011 19:10:48 EST news236887839 Researchers at the University of Pittsburgh School of Medicine have developed a mouse model of major depressive disorder (MDD) that is based on a rare genetic mutation that appears to cause MDD in the majority of people who inherit it. The findings, which were published online today in the American Journal of Medical Genetics Part B: Neuropsychiatric Genetics EarlyView, could help to clarify the brain events that lead to MDD, and contribute to the development of new and better means of treatment and prevention. This report also illustrates an advance in the design of recombinant mouse models that should be applicable to many human diseases. http://medicalxpress.com/news/2011-05-mouse-depression.html Genetics Thu, 19 May 2011 04:04:30 EST news224996648