http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. In a first-of-its-kind experiment using microvesicles generated from mesenchymal bone marrow cells (MSCs) to treat cancer, neurological researchers at Henry Ford Hospital have discovered a novel approach for treatment of tumor. Specifically, the research team found that introducing genetic material produced by MSCs, significantly reduced a particularly resistant form of malignant brain tumor in living lab rats. http://medicalxpress.com/news/2013-04-brain-cancer-treatment-genetic-material.html Cancer Mon, 01 Apr 2013 10:16:59 EST news284030172 A multi-institutional team led by Massachusetts General Hospital (MGH) researchers has identified a molecular pathway that appears to be essential for the growth and spread of medulloblastoma, the most common malignant brain tumor in children. In their report in the Feb. 28 issue of Cell, they show that blocking this pathway – which involves interactions between tumor cells and the surrounding tissues – leads to regression of all four molecular subtypes of medulloblastoma in several mouse models. http://medicalxpress.com/news/2013-02-growth-factor-essential-common-malignant.html Cancer Thu, 28 Feb 2013 12:33:45 EST news281277209 (HealthDay)—Corticorelin acetate (CrA) administration to patients with peritumoral brain edema (PBE) allows the reduction of steroid doses and is associated with reduced incidence and severity of steroid-induced myopathy and other steroid-related adverse effects, according to research published online Feb. 4 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2013-02-corticorelin-acetate-steroid-sparing-effect-brain.html Cancer Wed, 06 Feb 2013 15:00:01 EST news279384191 Researchers using sophisticated genetic testing techniques have identified a promising new biomarker for diagnosis of glioma—the most common type of malignant brain tumor, reports the January issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. http://medicalxpress.com/news/2013-01-biomarker-gliomas.html Cancer Wed, 16 Jan 2013 13:01:20 EST news277563674 Between the blueprint of the genome and the products of its expression lie microRNAs, which can boost or lower the rate at which genes become stuff. In fact, many cancers use microRNA to magnify the expression of faulty genes or shrink the expression of helpful genes that would otherwise suppress tumors. A University of Colorado Cancer Center study published in the December issue of the Journal of Biological Chemistry shows that in medulloblastoma, a malignant brain tumor of children, microRNA-218 is especially low. The article also shows that adding microRNA-218 to neural stem cells engineered to develop medulloblastoma decreases the development of the cancer. http://medicalxpress.com/news/2012-12-microrna-medulloblastoma-aggressive-childhood-brain.html Cancer Thu, 13 Dec 2012 10:37:29 EST news274617443 An experimental immune-based therapy more than doubled median survival of patients diagnosed with the most aggressive malignant brain tumor, Cedars-Sinai Medical Center researchers reported in Cancer Immunology, Immunotherapy, published online Aug. 3. http://medicalxpress.com/news/2012-08-vaccine-malignant-brain-cancer-antigens.html Immunology Wed, 15 Aug 2012 11:08:38 EST news264247704 A study by UT Southwestern Medical Center researchers published online today in Nature reveals new insight into why the most common, deadly kind of brain tumor in adults recurs and identifies a potential target for future therapies. http://medicalxpress.com/news/2012-08-treatment-glioblastoma-multiforme.html Cancer Wed, 01 Aug 2012 13:00:01 EST news263040203 Researchers at Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) and several collaborating institutions have linked mutations in specific genes to each of the four recognized subtypes of medulloblastoma, the most common malignant brain tumor of children. The discovery, reported July in the journal Nature, provides doctors with potential biomarkers for guiding and individualizing treatment and reveals prospective therapeutic opportunities for countering this devastating malignancy. http://medicalxpress.com/news/2012-07-key-mutations-medulloblastoma-common.html Cancer Sun, 22 Jul 2012 13:00:12 EST news262178469 Persistent protein expression may explain why tumors return after therapy in glioblastoma patients, according to a study published on March 5th in the Journal of Experimental Medicine. http://medicalxpress.com/news/2012-03-culprit-brain-tumor-resistance-therapy.html Cancer Mon, 05 Mar 2012 12:00:03 EST news250165773 Scientists at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center, in collaboration with colleagues in Boston and South Korea, say they have identified a novel gene mutation that causes at least one form of glioblastoma (GBM), the most common type of malignant brain tumor. http://medicalxpress.com/news/2011-11-drugs-brain-tumor.html Cancer Fri, 18 Nov 2011 14:40:01 EST news240847563 A research alliance of Heidelberg University Hospital and the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), jointly with colleagues of the Helmholtz Center for Environmental Research in Leipzig, have discovered a new metabolic pathway which makes malignant brain tumors (gliomas) more aggressive and weakens patients' immune systems. Using drugs to inhibit this metabolic pathway is a new approach in cancer treatment. The group's results have been published in the prestigious specialist journal Nature. http://medicalxpress.com/news/2011-10-dioxin-like-chemical-messenger-brain-tumors.html Cancer Thu, 06 Oct 2011 10:04:32 EST news237114238 New research suggests brain tumor patients who take the seizure drug valproic acid on top of standard treatment may live longer than people who take other kinds of epilepsy medications to control seizures. The research is published in the August 31, 2011, online issue of Neurology, the medical journal of the American Academy of Neurology. http://medicalxpress.com/news/2011-08-choice-seizure-drug-brain-tumor.html Neuroscience Wed, 31 Aug 2011 16:49:38 EST news234028149 Ependymomas are the second most frequent type of malignant brain tumor in children. Ependymoma develops from precursor cells of the tissue that lines the hollow cavities of the brain. Therapy results of ependymoma vary immensely: While in some patients tumor growth comes to a standstill after surgery and radiotherapy, in other children the disease rapidly takes a severe course. In about half of those affected the tumor continues to grow and the patients often succumb to the disease. http://medicalxpress.com/news/2011-08-brain-tumors-two-tier.html Cancer Tue, 23 Aug 2011 10:37:40 EST news233314628 Survival rates of wealthier patients and those younger than 70 with glioblastoma, the most common and aggressive malignant brain tumor, have improved since 2000, whereas rates for those living in poorer areas and older than 70 have remained stagnant, according to an abstract being presented at the American Society of Clinical Oncology annual meeting in Chicago by Thomas Jefferson University Hospital researchers on Saturday, June 4. http://medicalxpress.com/news/2011-06-glioblastoma-21st-century-wealthier-patients.html Cancer Thu, 02 Jun 2011 17:24:51 EST news226254275