http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A multi-institutional team led by Massachusetts General Hospital (MGH) researchers has identified a molecular pathway that appears to be essential for the growth and spread of medulloblastoma, the most common malignant brain tumor in children. In their report in the Feb. 28 issue of Cell, they show that blocking this pathway – which involves interactions between tumor cells and the surrounding tissues – leads to regression of all four molecular subtypes of medulloblastoma in several mouse models. http://medicalxpress.com/news/2013-02-growth-factor-essential-common-malignant.html Cancer Thu, 28 Feb 2013 12:33:45 EST news281277209 An analysis of breast cancer trends in the U.S. finds a small but statistically significant increase in the incidence of advanced breast cancer for women 25 to 39 years of age, without a corresponding increase in older women, according to a study appearing in the February 27 issue of JAMA. http://medicalxpress.com/news/2013-02-small-incidence-advanced-breast-cancer.html Cancer Tue, 26 Feb 2013 16:00:11 EST news281108310 Neuroblastoma, the most common malignant tumor of early childhood, is frequently associated with the presence of MYCN amplification, a genetic biomarker associated with poor prognosis. Researchers have determined that tumors containing MYCN amplification are sensitive to a new class of drugs, BET bromodomain inhibitors. http://medicalxpress.com/news/2013-02-biomarker-neuroblastomas-sensitivity-bromodomain-inhibitors.html Cancer Thu, 21 Feb 2013 10:32:14 EST news280665121 In a large epidemiologic study, researchers at UCLA's Jonsson Cancer Center found that the children of U.S.-born Latina women are at higher risk of having retinoblastoma, a malignant tumor of the retina which typically occurs in children under six. http://medicalxpress.com/news/2012-08-us-born-latinas-great-babies-retinoblastoma.html Cancer Mon, 06 Aug 2012 15:26:05 EST news263485549 An investigational drug that acts like a Trojan Horse to deliver cancer killing agents for pancreatic cancer is being studied at the Virginia G. Piper Cancer Center Clinical Trials, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute (TGen) that treats cancer patients with promising new drugs. http://medicalxpress.com/news/2012-06-trial-drug-trojan-horse-pancreatic.html Cancer Thu, 14 Jun 2012 09:00:19 EST news258883210 Inflammation, cell division and cell differentiation that occur during skeletal muscle regeneration may provide an ideal environment for the highly malignant tumor, rhabdomyosarcoma to arise. These are the findings from a Nationwide Children's Hospital study that examined rhabdomyosarcoma growth in mouse models of muscular dystrophy. The new models could help investigators search for factors that drive tumor growth and help test new therapies. http://medicalxpress.com/news/2012-02-muscle-regeneration-ideal-environment-rhabdomyosarcoma.html Cancer Wed, 22 Feb 2012 11:52:12 EST news249133922 The proliferation of metastases is often the main cause of complications and death from cancer. For the first time, researchers are looking very closely at the development of these metastases themselves, instead of focusing on the "primary" cancers from which they originated. In doing so, a team from the Swiss Center for Experimental Cancer Research (ISREC), at EPFL, was able to isolate a protein that plays a major role in metastasis development, and showed that the formation of secondary cancers could be prevented by blocking this protein. http://medicalxpress.com/news/2011-12-nipping-metastases-bud-strategy-cancer.html Cancer Wed, 07 Dec 2011 13:00:01 EST news242484916 When U.S. Sen. Edward Kennedy was diagnosed with a glioblastoma of the brain in May 2009, doctors understood there was little chance he could survive it. He died that August. http://medicalxpress.com/news/2011-11-brain-vaccine-aims-fatal-disease.html Cancer Tue, 29 Nov 2011 16:23:22 EST news241806177 Results of a study by Baylor College of Medicine physicians underscore the important role that clinical genetic evaluation can have in the management plan of patients with retinoblastoma, a childhood cancer of the eye. http://medicalxpress.com/news/2011-11-genetic-retinoblastoma.html Cancer Mon, 14 Nov 2011 16:00:03 EST news240490980 As an individual's level of vitamin D increases, the risk of nonmelanoma skin cancer (NMSC) seems to increase as well, although factors such as ultraviolet (UV) radiation exposure may complicate the relationship, according to a report published Online First by Archives of Dermatology. http://medicalxpress.com/news/2011-08-vitamin-d-skin-cancer-relationship.html Health Mon, 15 Aug 2011 17:37:47 EST news232648650