http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A drug developed by scientists at the Salk Institute for Biological Studies, known as J147, reverses memory deficits and slows Alzheimer's disease in aged mice following short-term treatment. The findings, published May 14 in the journal Alzheimer's Research and Therapy, may pave the way to a new treatment for Alzheimer's disease in humans. http://medicalxpress.com/news/2013-05-scientists-drug-alzheimer-mice.html Alzheimer's disease & dementia Mon, 13 May 2013 20:00:01 EST news287689272 Neuroscientists at The University of Texas Health Science Center at Houston (UTHealth) have taken a major step in their efforts to help people with memory loss tied to brain disorders such as Alzheimer's disease. http://medicalxpress.com/news/2013-04-scientists-reverse-memory-loss-animal.html Neuroscience Wed, 17 Apr 2013 16:42:36 EST news285435742 Researchers at the Institute for Comprehensive Medical Science, Fujita Health University and the National Institute for Physiological Sciences, Japan, along with colleagues from 9 other institutions, have identified an exceptional mouse model of schizophrenia. After screening over 160 mutant mouse strains with a systematic battery of behavioral tests, they identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia. Shn-2 is an NF-kappaB site-binding protein that binds enhancers of major histocompatibility complex class I genes and inflammatory cytokines, which harbor common variant single nucleotide polymorphisms associated with schizophrenia. The Shn-2 KO mice display behavioral abnormalities that resemble the symptoms of human schizophrenia, including working memory deficits, impaired nest building behavior (a measure of self-neglect), decreased social behaviors, and anhedonia (loss of the ability to experience pleasure). http://medicalxpress.com/news/2013-02-induction-mild-inflammation-cognitive-deficits.html Psychology & Psychiatry Wed, 06 Feb 2013 09:50:11 EST news279366453 (HealthDay)—People with insomnia may have double the chances of a heart attack or stroke as opposed to those who sleep well, a study by Taiwanese researchers suggests. http://medicalxpress.com/news/2012-11-insomnia-heart.html Health Mon, 05 Nov 2012 10:30:02 EST news271332395 The brain's key "breeder" cells, it turns out, do more than that. They secrete substances that boost the numbers and strength of critical brain-based immune cells believed to play a vital role in brain health. This finding adds a new dimension to our understanding of how resident stem cells and stem cell transplants may improve brain function. http://medicalxpress.com/news/2012-10-natural-brain-immune-cells-tissue.html Neuroscience Sun, 21 Oct 2012 13:00:17 EST news270017832 New studies presented today offer vivid examples of how advances in basic brain research help reduce the trauma and suffering of innocent landmine victims, amateur and professional athletes, and members of the military. The research was presented today at Neuroscience 2012, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health. http://medicalxpress.com/news/2012-10-traumatic-injury-citizens-soldiers.html Neuroscience Mon, 15 Oct 2012 10:32:54 EST news269515968 Scientists studying a rare genetic disorder have identified a molecular pathway that may play a role in schizophrenia, according to new research in the October 10 issue of The Journal of Neuroscience. The findings may one day guide researchers to new treatment options for people with schizophrenia—a devastating disease that affects approximately 1 percent of the world's population. http://medicalxpress.com/news/2012-10-rare-genetic-disorder-molecules-role.html Genetics Tue, 09 Oct 2012 17:00:01 EST news269020708 Columbia University Medical Center (CUMC) researchers have identified a potential medical treatment for the cognitive effects of stress-related disorders, including post-traumatic stress disorder (PTSD). The study, conducted in a PTSD mouse model, shows that an experimental drug called S107, one of a new class of small-molecule compounds called Rycals, prevented learning and memory deficits associated with stress-related disorders. The findings were published today in the online edition of Cell. http://medicalxpress.com/news/2012-08-potential-treatment-cognitive-effects-stress-related.html Psychology & Psychiatry Thu, 30 Aug 2012 12:00:05 EST news265546491 University of Florida researchers have identified a gene responsible for brain-related symptoms of the most common form of adult-onset muscular dystrophy. http://medicalxpress.com/news/2012-08-underlying-impaired-brain-function-muscular.html Neuroscience Wed, 08 Aug 2012 12:00:01 EST news263642344 A recent study finds that a new compound reverses many of the major symptoms associated with Fragile X syndrome (FXS), the most common form of inherited intellectual disability and a leading cause of autism. The paper, published by Cell Press in the April 12 issue of the journal Neuron, describes the exciting observation that the FXS correction can occur in adult mice, after the symptoms of the condition have already been established. http://medicalxpress.com/news/2012-04-fragile-syndrome-reversed-adult-mouse.html Neuroscience Wed, 11 Apr 2012 12:00:10 EST news253364173 The difficulties that many women describe as memory problems when menopause approaches are real, according to a study published today in the journal Menopause, the journal of the North American Menopause Society. http://medicalxpress.com/news/2012-03-brain-fog-menopause.html Medical research Wed, 14 Mar 2012 11:23:08 EST news250942976 (Medical Xpress) -- Researchers at the University of California, San Diego, the Medical University of South Carolina, the University of Cincinnati, and American Life Science Pharmaceuticals of San Diego have validated the protease cathepsin B (CatB) as a target for improving memory deficits and reducing the pathology of Alzheimer's disease (AD) in an animal model representative of most AD patients. The study has been published in the online edition of the Journal of Alzheimer's Disease. http://medicalxpress.com/news/2012-03-drug-memory-mouse-alzheimer-disease.html Alzheimer's disease & dementia Wed, 07 Mar 2012 15:41:03 EST news250357244 Working memory, which consists in the short-term retention and processing of information, depends on specific regions of the brain working correctly. This faculty tends to deteriorate in patients with schizophrenia, as it does in healthy aged subjects. http://medicalxpress.com/news/2012-02-memory-deficits-schizophrenic-patients-healthy.html Psychology & Psychiatry Thu, 23 Feb 2012 09:20:01 EST news249210260 Neuroscientists at Case Western Reserve University School of Medicine have made a dramatic breakthrough in their efforts to find a cure for Alzheimer's disease. The researchers' findings, published in the journal Science, show that use of a drug in mice appears to quickly reverse the pathological, cognitive and memory deficits caused by the onset of Alzheimer's. The results point to the significant potential that the medication, bexarotene, has to help the roughly 5.4 million Americans suffering from the progressive brain disease. http://medicalxpress.com/news/2012-02-fda-approved-drug-rapidly-amyloid-brain.html Neuroscience Thu, 09 Feb 2012 14:00:03 EST news248007423 The treatment for moderate-to-severe memory impairment could one day include a prescription for a smartphone. http://medicalxpress.com/news/2012-02-smartphone-people-memory-impairment-regain.html Psychology & Psychiatry Wed, 08 Feb 2012 12:29:54 EST news247926580 About half of newborns who have seizures go on to have long-term intellectual and memory deficits and cognitive disorders such as autism, but why this occurs has been unknown. In the December 14 Journal of Neuroscience, researchers at Children's Hospital Boston detail how early-life seizures disrupt normal brain development, and show in a rat model that it might be possible to reverse this pathology by giving certain drugs soon after the seizure. http://medicalxpress.com/news/2011-12-dodging-cognitive-early-life-seizures.html Neuroscience Tue, 13 Dec 2011 17:00:06 EST news243005693 The brains of individuals with Alzheimer's disease contain protein aggregates called plaques and tangles, which interfere with normal communication between nerve cells and cause progressive learning and memory deficits. Now, a research team led by Takaomi Saido from the RIKEN Brain Science Institute in Wako has identified a particular fragment of the amyloid precursor protein (APP) that contributes to the formation of plaques in the brain. http://medicalxpress.com/news/2011-12-characterizing-toxic.html Neuroscience Fri, 09 Dec 2011 06:50:02 EST news242635245 A diametric shift in the levels of two proteins involved in folding, moving and cutting other proteins enables accumulation of the destructive brain plaque found in Alzheimer's disease, researchers report. http://medicalxpress.com/news/2011-12-diametric-shift-protein-spurs-alzheimer.html Medical research Thu, 01 Dec 2011 12:00:02 EST news241962075 (Medical Xpress) -- Chronic stress in childhood can hurt children and teens physically, mentally and emotionally. However, having a sensitive, responsive mother can reduce at least one of these harmful effects, reports a new Cornell study. It shows that such moms can help buffer the effects of chronic stress on teens' working memories. http://medicalxpress.com/news/2011-11-mom-buffer-effects-stress-teen.html Psychology & Psychiatry Tue, 01 Nov 2011 06:45:47 EST news239348678 A new biomarker may help identify which people with mild memory deficits will go on to develop Alzheimer's disease, according to a new study published in the June 22, 2011, online issue of Neurology, the medical journal of the American Academy of Neurology. The biomarker may be more accurate than the currently established biomarkers. http://medicalxpress.com/news/2011-06-biomarker-early-diagnosis-alzheimer-disease.html Neuroscience Wed, 22 Jun 2011 16:33:20 EST news227979178 Scientists at the Gladstone Institutes have identified a drug candidate that diminishes the effects of both Alzheimer's disease and Huntington's disease in animal models, offering new hope for patients who currently lack any medications to halt the progression of these two debilitating illnesses. http://medicalxpress.com/news/2011-06-scientists-drug-candidate-alzheimer-huntington.html Medical research Thu, 02 Jun 2011 13:43:10 EST news226240874