http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. An article published on the journal Nature describes the major role that Pyruvate dehydrogenase (PDH) —an enzyme of cellular energy metabolism— plays in the regulation of the cellular senescence induced by the oncogene BRAF, which usually appears mutated in melanoma and other cancers. http://medicalxpress.com/news/2013-05-factor-oncogene-induced-senescence.html Cancer Tue, 21 May 2013 08:46:11 EST news288344761 Making more use of in-vitro testing, the upcoming 21st-century scientific fields known as 'omics' sciences and developing smart test strategies can clearly reduce the amount of essential animal testing. This is the view of Professor Bennard van Ravenzwaay in his inaugural speech on accepting the endowed chair in Reproduction and Developmental Toxicology at Wageningen University on 2 May. His chair will be funded by BASF and is part of the sub-department of Toxicology. http://medicalxpress.com/news/2013-05-methods-amount-animal.html Medical research Tue, 07 May 2013 08:50:03 EST news287135129 (Medical Xpress)—Expertise at Pacific Northwest National Laboratory contributed to the understanding of the role of cellular metabolism in the pathogenesis of a currently untreatable lung disease. This research, reported in the American Journal of Respiratory and Critical Care Medicine, highlights the importance of PNNL's nuclear magnetic resonance (NMR) metabolomics in the field of biomedicine. http://medicalxpress.com/news/2013-01-metabolomics-key-disease-pathway-reveals.html Diseases, Conditions, Syndromes Mon, 14 Jan 2013 07:07:20 EST news277369632 Researchers at Moffitt Cancer Center have identified metabolic signatures that may pave the way for personalized therapy in glioma, a type of tumor that starts in the brain. http://medicalxpress.com/news/2012-11-metabolic-aggressive-brain-tumors.html Cancer Fri, 09 Nov 2012 13:15:53 EST news271689336 Investigators at Washington University and The Scripps Research Institute have announced the launch of a "Global Metabolomic Initiative" to facilitate meta-analyses on studies of the metabolism of bacteria, yeast, plants, animals and people. http://medicalxpress.com/news/2012-11-global-metabolomic-scientists-uncharted-metabolome.html Other Wed, 07 Nov 2012 07:37:28 EST news271496229 Mitochondria -- subunits inside cells that produce energy -- have long been thought to play a role in Alzheimer's disease. Now Mayo Clinic researchers using genetic mouse models have discovered that mitochondria in the brain are dysfunctional early in the disease. The findings appear in the journal PLoS ONE. http://medicalxpress.com/news/2012-02-mitochondrial-dysfunction-early-alzheimer-memory.html Alzheimer's disease & dementia Wed, 29 Feb 2012 18:40:01 EST news249762272 Progressive deafness profoundly influenced Beethoven's compositions, prompting him to choose lower-frequency notes as his condition worsened, scientists said on Tuesday. http://medicalxpress.com/news/2011-12-deafness-beethoven-music.html Other Tue, 20 Dec 2011 18:42:06 EST news243628887 Statins can be effective at lowering cholesterol, but they have a perplexing tendency to work for some people and not others. Gut bacteria may be the reason. http://medicalxpress.com/news/2011-10-gut-bacteria-affect-statin-drug.html Medical research Thu, 13 Oct 2011 17:00:04 EST news237733100