http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. In a landmark cancer study published online in Nature, researchers at NYU School of Medicine have unraveled a longstanding mystery about how pancreatic tumor cells feed themselves, opening up new therapeutic possibilities for a notoriously lethal disease with few treatment options. Pancreatic cancer kills nearly 38,000 Americans annually, making it a leading cause of cancer death. The life expectancy for most people diagnosed with it is less than a year. http://medicalxpress.com/news/2013-05-breakthrough-pancreatic-cancer-cells-ingest.html Cancer Mon, 13 May 2013 16:47:33 EST news287682443 While the search continues for the Fountain of Youth, researchers may have found the body's "fountain of aging": the brain region known as the hypothalamus. For the first time, scientists at Albert Einstein College of Medicine of Yeshiva University report that the hypothalamus of mice controls aging throughout the body. Their discovery of a specific age-related signaling pathway opens up new strategies for combating diseases of old age and extending lifespan. The paper was published today in the online edition of Nature. http://medicalxpress.com/news/2013-05-brain-region-key-aging.html Neuroscience Wed, 01 May 2013 13:00:16 EST news286626225 Researchers have discovered a unique monoclonal antibody that can effectively reach inside a cancer cell, a key goal for these important anticancer agents, since most proteins that cause cancer or are associated with cancer are buried inside cancer cells. Scientists from Memorial Sloan-Kettering Cancer Center and Eureka Therapeutics have collaborated to create the new human monoclonal antibody, which targets a protein associated with many types of cancer and is of great interest to cancer researchers. http://medicalxpress.com/news/2013-03-monoclonal-antibody-proteins-cancer-cells.html Cancer Wed, 13 Mar 2013 14:15:59 EST news282402953 University of Pittsburgh Cancer Institute (UPCI) researchers have uncovered a technique to halt the growth of cancer cells, a discovery that led them to a potential new anti-cancer therapy. http://medicalxpress.com/news/2013-02-reveal-mechanism-halt-cancer-cell.html Cancer Mon, 04 Feb 2013 04:30:27 EST news279174611 Mice deficient in PTEN in the prostate developed stable precancers. Androgen deprivation promoted progression to invasive prostate cancer. Patients with PTEN-deficient prostate precancers may not benefit from androgen deprivation chemoprevention therapy. http://medicalxpress.com/news/2012-12-prostate-cancer-androgen-deprivation-effects.html Cancer Thu, 20 Dec 2012 10:39:48 EST news275222382 (Medical Xpress)—Bisphenol A, a substance found in many synthetic products, is considered to be harmful, particularly, for fetuses and babies. Researchers from the University of Bonn have now shown in experiments on cells from human and mouse tissue that this environmental chemical blocks calcium channels in cell membranes. Similar effects are elicited by drugs used to treat high blood pressure and cardiac arrhythmia. The results are now presented in the journal Molecular Pharmacology. http://medicalxpress.com/news/2012-12-adverse-effects-bisphenol-calcium-channels.html Medical research Thu, 06 Dec 2012 08:11:37 EST news274003814 New understanding of how drugs called PARP inhibitors, which have already shown promise for the treatment of women with familial breast and ovarian cancers linked to BRCA mutations, exert their anticancer effects has led to the identification of ways in which the patient population that might benefit from PARP inhibitors could be expanded. http://medicalxpress.com/news/2012-11-mechanism-action-parp-inhibitors.html Cancer Fri, 09 Nov 2012 11:29:43 EST news271682973 A new class of drug developed at Northwestern University Feinberg School of Medicine shows early promise of being a one-size-fits-all therapy for Alzheimer's disease, Parkinson's disease, multiple sclerosis and traumatic brain injury by reducing inflammation in the brain. http://medicalxpress.com/news/2012-07-drug-alzheimer-multiple-sclerosis-brain.html Neuroscience Tue, 24 Jul 2012 17:09:11 EST news262368535 Investigators at the Center for Structural Genomics of Infectious Diseases (CSGID) and the Seattle Structural Genomics Center for Infectious Disease (SSGCID) announced today that they reached a significant milestone by determining 1,000 protein structures from infectious disease organisms. The knowledge gained from these structures should lead to new interventions for the deadly diseases caused by these pathogens. http://medicalxpress.com/news/2012-06-scientists-protein-infectious-disease.html Diseases, Conditions, Syndromes Tue, 05 Jun 2012 15:54:04 EST news258130413 Purdue University researchers revealed how a mutation in a protein shuts down a protective function needed to prevent the death of neurons in Parkinson's disease, possibly opening the door to new drug strategies to treat the disorder. http://medicalxpress.com/news/2012-02-purdue-reveal-role-protein-mutation.html Parkinson's & Movement disorders Tue, 21 Feb 2012 12:39:26 EST news249050344 The United States Patent and Trademark Office has reaffirmed the validity of four important patents in the field of RNA therapeutics. http://medicalxpress.com/news/2011-12-patent-office-affirms-zamore-patents.html Medical research Mon, 12 Dec 2011 16:38:43 EST news242930311 MicroRNAs (miRNAs) that regulate processes including fertilization, development, and aging show promise as biomarkers of disease. They can be collected from routinely collected fluids such as blood, saliva, and urine. However, a number of factors can interfere with the accuracy of miRNA tests. In a study published online today in the Journal of Molecular Diagnostics, a group of researchers provide clear procedures for the collection and analysis of miRNA, significantly improving their diagnostic accuracy. http://medicalxpress.com/news/2011-12-protocols-micrornas-diagnosis.html Medical research Wed, 07 Dec 2011 04:49:25 EST news242455755 One major obstacle in the fight against cancer is that anticancer drugs often affect normal cells in addition to tumor cells, resulting in significant side effects. Yet research into development of less harmful treatments geared toward the targeting of specific cancer-causing mechanisms is hampered by lack of knowledge of the molecular pathways that drive cancers in individual patients. http://medicalxpress.com/news/2011-12-tumor-targeting-compound-personalized-cancer-treatments.html Cancer Thu, 01 Dec 2011 16:00:01 EST news241977044 Moderate social drinking significantly reduces the risk of dementia and cognitive impairment, according to an analysis of 143 studies by Loyola University Chicago Stritch School of Medicine researchers. http://medicalxpress.com/news/2011-08-moderate-alzheimer-cognitive-impairment.html Addiction Tue, 16 Aug 2011 09:15:23 EST news232704904 Cells often communicate with one another using pulsatile signals, where information is conveyed in pulse frequency as well as amplitude. This raises the question of how cells decode pulsatile signals, a question that lies at the core of our understanding of how the brain controls reproduction. http://medicalxpress.com/news/2011-08-cell.html Medical research Wed, 03 Aug 2011 03:51:37 EST news231562133