http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A report from investigators at the Massachusetts General Hospital (MGH) Cancer Center has defined the role of a recently identified gene abnormality in a deadly form of lung cancer. Tumors driven by rearrangements in the ROS1 gene represent 1 to 2 percent of non-small-cell lung cancers (NSCLC), the leading cause of cancer death in the U.S. The researchers show that ROS1-driven tumors can be treated with crizotinib, which also inhibits the growth of tumors driven by an oncogene called ALK, and describe the remarkable response of one patient to crizotinib treatment. http://medicalxpress.com/news/2012-01-genetic-subtype-lung-cancer.html Cancer Tue, 31 Jan 2012 12:44:38 EST news247236268 Doctors and researchers of Hospital del Mar and its research institute, the IMIM, have lead a study describing a new pharmacological resistance to cancer. This new mechanism is a mutation in an oncogene called EGFR (epidermal growth factor receptor) causing resistance to treatment using a drug called cetuximab, a monoclonal antibody which specifically attacks the EGFR. http://medicalxpress.com/news/2012-01-resistance-colon-cancer-treatment.html Cancer Sun, 22 Jan 2012 13:04:32 EST news246459858 Often, and without much warning, pancreatic cancer cells slip through the endothelial cells, head into the blood and out to other parts of the body to metastasize, making it one of the deadliest and hardest to treat cancers today. http://medicalxpress.com/news/2011-12-potential-metastatic-pancreatic-cancer-prolong.html Cancer Wed, 21 Dec 2011 11:41:27 EST news243690073 Just as people's bodies and minds can become addicted to substances such as drugs, caffeine, alcohol, their cancers can become addicted to certain genes that insure their continued growth and dominance. http://medicalxpress.com/news/2011-12-oncogene-cancer-cell-treatment.html Cancer Thu, 08 Dec 2011 14:00:02 EST news242573362 Scientists at Joslin Diabetes Center in Boston have uncovered important molecular and genetic keys to the development of soft-tissue sarcomas in skeletal muscle, giving researchers and clinicians additional targets to stop the growth of these often deadly tumors. http://medicalxpress.com/news/2011-11-genetic-molecular-mystery-soft-tissue-sarcoma.html Cancer Wed, 30 Nov 2011 12:25:26 EST news241878317 A new study from the University of Hawaii Cancer Center reveals that PEA-15, a protein previously shown to slow ovarian tumor growth and metastasis, can alternatively enhance tumor formation in kidney cells carrying a mutation in a cancer-promoting gene called H-Ras. http://medicalxpress.com/news/2011-11-role-pea-protein-cancer-growth.html Cancer Mon, 21 Nov 2011 16:17:51 EST news241114663 Researchers from Virginia Commonwealth University Massey Cancer Center and the VCU Institute of Molecular Medicine have discovered a mechanism by which glioblastoma multiforme (GBM), the most common form of brain cancer, promotes the loss of function or death of neurons, a process known as neurodegeneration. http://medicalxpress.com/news/2011-11-mechanism-brain-cancer-responsible-neuron.html Medical research Thu, 03 Nov 2011 11:00:01 EST news239534512 Carefully tracking the rate of response of human lung tumors during the first weeks of treatment can predict which cancers will undergo sustained regression, suggests a new study by researchers at the Stanford University School of Medicine. http://medicalxpress.com/news/2011-10-math-formula-success-cancer-therapies.html Medical research Wed, 05 Oct 2011 14:00:01 EST news237038276 Like snakes, tumour cells shed their skin. Cancer is not a static disease but during its development the disease accumulates changes to evade natural defences adapting to new environmental circumstances, protecting against chemotherapy and radiotherapy and invading neighbouring organs, eventually causing metastasis. http://medicalxpress.com/news/2011-09-cancer-cells.html Cancer Fri, 02 Sep 2011 09:19:11 EST news234173936 A team of scientists at Cold Spring Harbor Laboratory (CSHL) has laid bare the mechanism behind a phenomenon called oncogene addiction in mice suffering from a form of leukemia that mimics acute myelogenous leukemia (AML) in humans. Significantly, the team was able to mobilize their newly gained understanding to target "addiction" pathways in the model mice, resulting in rapid and complete eradication of the cancer, which is usually fatal and resistant to conventional chemotherapy. http://medicalxpress.com/news/2011-08-scientists-reveal-mechanism-oncogene-addiction.html Addiction Mon, 01 Aug 2011 04:34:42 EST news231392042 Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells. Scientists at the Keck School of Medicine of the University of Southern California (USC) have proven that those genes also can change normal cells into stem-like cells, paving the way to a safer and more practical approach to treating diseases like multiple sclerosis and cancer with stem cell therapy. http://medicalxpress.com/news/2011-07-cancer-cells-stem.html Cancer Mon, 18 Jul 2011 17:22:13 EST news230228522 Researchers have identified a protein long known to regulate gene expression as a potent suppressor of breast cancer growth. Their study, in the journal Oncogene, is the first to demonstrate how this protein, known as Runx3, accomplishes this feat. http://medicalxpress.com/news/2011-06-team-breast-cancer-tumor-suppressor.html Cancer Mon, 27 Jun 2011 09:47:33 EST news228386815 A mutant gene long thought to accelerate tumor growth in thyroid cancer patients actually inhibits the spread of malignant cells, showing promise for novel cancer therapies, a Mayo Clinic study has found. http://medicalxpress.com/news/2011-06-cancer-mayo-clinic-thyroid-gene.html Cancer Sat, 04 Jun 2011 13:45:36 EST news226413912 Leukemia is the most common childhood cancer; it also occurs in adults. Now researchers working with zebrafish at Huntsman Cancer Institute (HCI) at the University of Utah have identified previously undiscovered high-risk genetic features in T-cell acute lymphocytic leukemia (T-ALL), according to an article published online May 9, 2011, in the cancer research journal Oncogene. When compared to samples from human patients with T-ALL, these genetic characteristics allowed scientists to predict which patients may have more aggressive forms of the disease that either recur after remission or do not respond to treatment. http://medicalxpress.com/news/2011-05-zebrafish-high-risk-genetic-features-leukemia.html Genetics Tue, 10 May 2011 12:32:01 EST news224249478