http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Platinum compounds, such as cisplatin and carboplatin, induce DNA cross-linking, prohibiting DNA synthesis and repair in rapidly dividing cells. They are first line therapeutics in the treatment of many solid tumors, but cancer cells frequently develop resistance to these drugs. http://medicalxpress.com/news/2013-04-resistance-futile-gene-cisplatin-ovarian.html Cancer Mon, 15 Apr 2013 12:00:09 EST news285240110 A new antibody-guided drug has shown promising activity in a phase I trial involving ovarian cancer patients with platinum drug-resistant disease, researchers from Dana-Farber Cancer Institute will report today at the annual meeting of the American Association for Cancer Research. The findings (abstract LB-290) will be discussed at a press conference on Saturday, April 06, 2013, and later at an oral presentation on Tuesday, April 09, 2013. http://medicalxpress.com/news/2013-04-toxin-platinum-resistant-ovarian-cancers.html Cancer Sat, 06 Apr 2013 14:39:16 EST news284477951 An extract from a shrub often used for medicinal purposes in tropical Africa may have lethal effects against a dangerous parasite that transmits malaria, according to a multi-institutional team of scientists led by researchers at Virginia Tech. http://medicalxpress.com/news/2013-03-cancer-slowing-compound-combats-malaria.html Medical research Fri, 08 Mar 2013 08:24:29 EST news281953462 Researchers employed an extensive analysis of genomic information to identify a new, high-risk cohort of ovarian cancer patients, characterize their tumors, find a potential treatment and test it in mouse models of the disease. http://medicalxpress.com/news/2013-02-deep-genomic-analysis-micro-rna.html Cancer Mon, 11 Feb 2013 15:37:36 EST news279819376 Unraveling the mechanism that ovarian cancer cells use to change normal cells around them into cells that promote tumor growth has identified several new targets for treatment of this deadly disease. http://medicalxpress.com/news/2012-11-micrornas-cells-cancer.html Cancer Wed, 21 Nov 2012 10:00:01 EST news272714077 (Medical Xpress)—New Georgia Tech research shows that cell stiffness could be a valuable clue for doctors as they search for and treat cancerous cells before they're able to spread. The findings, which are published in the journal PLoS One, found that highly metastatic ovarian cancer cells are several times softer than less metastatic ovarian cancer cells. http://medicalxpress.com/news/2012-10-ovarian-cancer-cells-metastatic-potential.html Cancer Wed, 10 Oct 2012 15:41:04 EST news269102452 Ovarian cancer takes the lives of nearly 900 Australian women each year. It's called the silent killer because by the time most cases are detected, the cancer has spread to other vital organs throughout the abdominal area. http://medicalxpress.com/news/2012-10-ovarian-cancer-stem-cells.html Cancer Fri, 05 Oct 2012 09:17:30 EST news268647442 Scientists at USC have discovered a new type of drug for the treatment of ovarian cancer that works in a way that should not only decrease the number of doses that patients need to take, but also may make it effective for patients whose cancer has become drug-resistant. http://medicalxpress.com/news/2012-10-drug-resistant-ovarian-cancer.html Cancer Wed, 03 Oct 2012 14:48:24 EST news268494489 Dr. Anglea Wandinger-Ness and Dr. Laurie Hudson were awarded a Provocative Questions grant to investigate the use of R-ketorolac against ovarian cancer. Ketorolac is an NSAID that the FDA approved for human use in 1991. They are investigating their hypothesis that R-ketorolac, and not S-ketorolac, acts on GTPases in the cell to control cell adhesion and growth in ovarian cancer cells. http://medicalxpress.com/news/2012-09-drug.html Medications Thu, 27 Sep 2012 13:44:25 EST news267972257 A new discovery that sheds light on the genetic make up of ovarian cancer cells could explain why some women survive longer than others with this deadly disease. A multi-disciplinary team led by the Research Institute of the McGill University Health Centre (RI MUHC), in collaboration with the Lady Davis Institute of the Jewish General Hospital and the University of Montreal Hospital Research Centre, has identified genetic patterns in ovarian cancer tumours that help to differentiate patients based on the length of their survival after initial surgery. The study was published in the journal PLOS ONE. http://medicalxpress.com/news/2012-09-ovarian-cancer-pathways-genetics.html Cancer Mon, 24 Sep 2012 15:48:13 EST news267720458 (Medical Xpress)—Researchers from the University of Dundee have discovered that measuring how active a gene is could predict which women with ovarian cancer will benefit from platinum-based chemotherapy drugs - a common treatment for the disease. http://medicalxpress.com/news/2012-09-gene-ovarian-cancer-benefit-chemotherapy.html Cancer Wed, 19 Sep 2012 07:39:15 EST news267259149 Tumor growth is dependent on interactions between cancer cells and adjacent normal tissue, or stroma. Stromal cells can stimulate the growth of tumor cells; however it is unclear if tumor cells can influence the stroma. http://medicalxpress.com/news/2012-09-ovarian-cancer-cells-hijack-tissues.html Cancer Tue, 04 Sep 2012 12:00:16 EST news265962735 (Medical Xpress) -- A new study by TCD researchers investigates drug-resistant ovarian cancer cells. The findings which have been recently published in the international publication, PLoS One will increase understanding of molecular markers in drug-resistant ovarian cancer with a view to improving clinical treatment. http://medicalxpress.com/news/2012-08-drug-resistant-ovarian-cancer-clinical.html Cancer Thu, 09 Aug 2012 08:47:52 EST news263720848 As the medical community continues to make positive strides in personalized cancer therapy, scientists know some dead ends are unavoidable. Drugs that target specific genes in cancerous cells are effective, but not all proteins are targetable. In fact, it has been estimated that as few as 10 to 15 percent of human proteins are potentially targetable by drugs. For this reason, Georgia Tech researchers are focusing on ways to fight cancer by attacking defective genes before they are able to make proteins. http://medicalxpress.com/news/2012-08-millions-years-cell-evolution-cancer.html Genetics Tue, 07 Aug 2012 13:23:26 EST news263564589 Scientists from Brigham and Women's Hospital and Dana-Farber Cancer Institute and their colleagues have found a genetic marker that predicts which aggressive "triple negative" breast cancers and certain ovarian cancers will likely respond to platinum-based chemotherapies. http://medicalxpress.com/news/2012-03-dna-marker-platinum-drug-response.html Cancer Thu, 22 Mar 2012 10:48:26 EST news251632099 Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the presence and integrity of the opioid growth factor receptor (OGFr), which mediates the inhibitory action of opioid growth factor (OGF) on cell proliferation, is a key to understanding the progression and treatment of human ovarian cancer. Transplantation of human ovarian cancer cells that were molecularly engineered to have a reduced expression of OGFr, into immunocompromised mice resulted in ovarian tumors that grew rapidly. This discovery, reported in the February 2012 issue of Experimental Biology and Medicine, provides fresh new insights into the pathogenesis and therapy of a lethal cancer that is the fifth leading cause of cancer-related mortality among women in the USA, and has a death rate that is unchanged for over 75 years. http://medicalxpress.com/news/2012-02-breakthrough-biology-treatment-ovarian-cancer.html Cancer Tue, 21 Feb 2012 16:09:21 EST news249062956 A recent study published in Clinical Cancer Research suggests that the protein hVps37A suppresses tumor growth in ovarian cancer. The work, which was funded by the Austrian Science Fund FWF, shows, for the first time, that this protein is significantly reduced in ovarian cancer cells. The scientists also found that this reduction affects a cellular signalling pathway that is associated with the membrane receptor EGFR (Epidermal Growth Factor Receptor). The receptor is considered an important biological marker for the course of the disease and therapy, and also serves as a target for modern treatment of different cancer types. In fact, the cells in which hVps37A synthesis was reduced showed resistance to Cetuximab, an approved substance for inhibition of EGFR activity. http://medicalxpress.com/news/2012-02-tumor-suppressor-gene.html Cancer Mon, 13 Feb 2012 08:04:02 EST news248342629 Ovarian cancer is a major cause of death worldwide. Approximately 25,000 women will be diagnosed with ovarian cancer this year and 15,000 women will die from it in the United States alone. The novel anti-cancer drug diindolylmethane (DIM) has been shown in laboratory to inhibit the growth of ovarian cancer cells. New research published in BioMed Central's open access journal BMC Medicine has looked in detail at the action of DIM and showed that it works by blocking the activation and production of the transcription factor STAT3. DIM also enhances the anti-cancer effect of the platinum-based chemotherapy drug cisplatin. http://medicalxpress.com/news/2012-01-dimming-cancer-growth-stat.html Cancer Thu, 26 Jan 2012 04:22:24 EST news246774136 (Medical Xpress) -- Researchers from the Perelman School of Medicine at the University of Pennsylvania are in the midst of testing a personalized, dendritic cell vaccine in patients with recurrent ovarian, primary peritoneal or fallopian tube cancer – a group of patients who typically have few treatment options. Now, they have shown they can shorten the time to manufacture this type of anti-cancer vaccine, which reduces costs of manufacturing the treatment while still yielding powerful dendritic cells that may be beneficial for these and a variety of other tumor types. The data is published in the December issue of PLoS ONE. http://medicalxpress.com/news/2011-12-shorten-personalized-ovarian-cancer-vaccine.html Cancer Mon, 26 Dec 2011 07:01:24 EST news244105188 A large pad of fat cells that extends from the stomach and covers the intestines provides nutrients that promote the spread and growth of ovarian cancer, reports a research team based at the University of Chicago in the journal Nature Medicine, published online October 30th, 2011. http://medicalxpress.com/news/2011-10-fat-cells-abdomen-fuel-ovarian.html Cancer Sun, 30 Oct 2011 14:00:11 EST news239200932 For patients with ovarian cancer and their physicians, resistance to chemotherapy is a serious concern. However, researchers at Moffitt Cancer Center have identified a molecular pathway that may play a key role in the evolution of chemotherapy resistance. They are hopeful that the discovery may lead to therapies that are tailored to individual patients with ovarian cancer; reversing resistance to chemotherapy and improving survival from the disease. http://medicalxpress.com/news/2011-09-key-chemotherapy-resistance-ovarian-cancer.html Cancer Thu, 15 Sep 2011 12:24:16 EST news235308222 Canadian researchers have discovered that a tumor cell marker is a receptor for measles virus, suggesting the possible use of measles virus to help fight cancer. Their findings appear in the Open Access journal PLoS Pathogens on August 25th. http://medicalxpress.com/news/2011-08-cell-receptor-measles-virus-tumors.html Cancer Thu, 25 Aug 2011 17:48:13 EST news233513282 Mayo Clinic has received investigational new drug approval from the Food and Drug Administration for two new cancer vaccines that mobilize the body's defense mechanisms to destroy malignant cells. The vaccines are among the first aimed at preventing cancer recurrence. The approval clears the way for Phase I clinical trials with women treated for ovarian or breast cancer. http://medicalxpress.com/news/2011-08-mayo-clinic-fda-ovarian-breast.html Cancer Wed, 17 Aug 2011 13:46:24 EST news232807571 In a recent issue of Cancer Research, Daniel J. Powell, Jr., PhD, a research assistant professor of Pathology and Laboratory Medicine and Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania, showed for the first time that engineered human T cells can eradicate deadly human ovarian cancer in immune-deficient mice. Ovarian cancer is the most lethal reproductive cancer for women, with one-fifth of women diagnosed with advanced disease surviving five years. Nearly all ovarian cancers (90%) are characterized by their expression of a distinct cell-surface protein called alpha-folate receptor, which can be a target for engineered T cells. http://medicalxpress.com/news/2011-08-effective-approach.html Cancer Mon, 08 Aug 2011 10:50:01 EST news232018837 A team of German and Italian EU-funded scientists has designed peptides that can target the protein-protein interface of an enzyme that plays a key part in the DNA synthesis crucial for cancer growth. http://medicalxpress.com/news/2011-08-peptides-ovarian-cancer.html Cancer Mon, 08 Aug 2011 10:22:28 EST news232017724 Targeted therapies that are designed to suppress the formation of new blood vessels in tumors, such as Avastin (bevacizumab), have slowed cancer growth in some patients. However, they have not produced the dramatic responses researchers initially thought they might. Now, research from the Perelman School of Medicine at the University of Pennsylvania might help to explain the modest responses. The discovery, published in the July 14 issue of Nature, suggests novel treatment combinations that could boost the power of therapies based on slowing blood vessel growth (angiogenesis). http://medicalxpress.com/news/2011-07-scientists-link-immune-suppression-blood.html Cancer Wed, 13 Jul 2011 13:00:09 EST news229780313 A team led by Joan Brugge, the Louise Foote Pfeiffer Professor of Cell Biology at Harvard Medical School, recently shed light on how ovarian cancer spreads. In a paper published in the July edition of the journal Cancer Discovery, the newest journal of the American Association for Cancer Research, Brugge and colleagues found that ovarian cancer cells act like bullies, using brute force to plow their way through tissue and colonize additional organs. http://medicalxpress.com/news/2011-06-scientists-image-stages-ovarian-cancer.html Cancer Tue, 14 Jun 2011 13:38:29 EST news227277494