http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. It is estimated that between 5% and 10% of breast and ovarian cancers are familial in origin, which is to say that these tumours are attributable to inherited mutations from the parents in genes such as BRCA1 or BRCA2. In patients with these mutations, PARP inhibitors, which are currently in clinical trials, have shown encouraging results that make them a new option for personalised cancer treatment, an alternative to standard chemotherapy. Nevertheless, the latest studies indicate that a fraction of these patients generate resistance to the drug and, therefore, stop responding to the new treatment. http://medicalxpress.com/news/2013-06-cell-article-reveals-resistance-mechanism.html Cancer Tue, 18 Jun 2013 11:35:57 EST news290774132 (Medical Xpress)—Approximately 90 percent of cancers start within tissues that form the inner linings of various organs. Decades of accumulated genetic mutations can, on occasion, induce cells specialized for growth in one-cell deep sheets to form disordered clumps that eventually become tumors. http://medicalxpress.com/news/2013-05-cancer-driver-monoclonal-antibody-therapy.html Cancer Wed, 08 May 2013 07:40:04 EST news287216212 KISS 1 is a metastasis-suppressor gene which helps to prevent the spread of cancers, including melanoma, pancreatic and ovarian cancers to name a few. But new research from Western University's Schulich School of Medicine & Dentistry shows that kisspeptins –peptide products of KISS1, actually make some breast cancers worse, with a higher tumor grade and metastatic potential. The research is published online in the journal Endocrinology. http://medicalxpress.com/news/2013-04-breast-cancer-linked-kisspeptins-inhibit.html Cancer Tue, 16 Apr 2013 15:05:00 EST news285343494 Interferons have antitumor activity and have been used to treat a variety of malignancies, including colorectal and ovarian cancers. However, their effectiveness varies. A clearer understanding of the role of interferon in immune-mediated tumor cell death and how its antitumor effects could be optimized are presented in a comprehensive Review article published in Journal of Interferon & Cytokine Research. http://medicalxpress.com/news/2013-04-approaches-maximize-antitumor-interferon.html Medical research Tue, 16 Apr 2013 11:25:51 EST news285330333 Men are over 35 per cent more likely to die from cancer than women in the UK, according to a new report released today . http://medicalxpress.com/news/2013-01-cancer-death-higher-men-women.html Cancer Tue, 29 Jan 2013 06:40:04 EST news278663193 A new study by Georgetown University Medical Center researchers reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth. http://medicalxpress.com/news/2012-12-uncovers-mechanism-brca1-suppress-tumors.html Cancer Mon, 17 Dec 2012 06:00:01 EST news274903771 New understanding of how drugs called PARP inhibitors, which have already shown promise for the treatment of women with familial breast and ovarian cancers linked to BRCA mutations, exert their anticancer effects has led to the identification of ways in which the patient population that might benefit from PARP inhibitors could be expanded. http://medicalxpress.com/news/2012-11-mechanism-action-parp-inhibitors.html Cancer Fri, 09 Nov 2012 11:29:43 EST news271682973 (Medical Xpress)—Researchers led by Tanya Stoyanova and Dr. Owen Witte of UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have determined how a protein known as Trop2 drives the growth of tumor cells in prostate and other epithelial cancers. http://medicalxpress.com/news/2012-10-reveal-trop2-protein-tumor-growth.html Cancer Tue, 16 Oct 2012 07:33:15 EST news269591570 Postdoctoral Research Fellow Devin Koestler is a biostatistician in the Geisel School of Medicine at Dartmouth. He develops and applies statistical methods to large volumes of data, seeking new approaches for understanding disease, cancer in particular. Koestler and his colleagues are investigating the potential use of white blood cell variation as a diagnostic, predictive, and research tool in the study of non-blood cancers. http://medicalxpress.com/news/2012-10-blood-cells-telltale-clues-cancer.html Cancer Fri, 12 Oct 2012 17:08:06 EST news269280478 Poly (ADP-Ribose) polymerase (PARP) inhibitors, shown to have clinical activity when used alone in women with familial breast and ovarian cancers linked to BRCA mutations, may be a novel treatment strategy in women with HER2-positive breast cancers, according to the results of a study published in Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-09-parp-inhibitors-clinical-her2-positive-breast.html Cancer Mon, 17 Sep 2012 00:20:01 EST news267018005 (Medical Xpress)—In a study to decipher clues about how prostate cancer cells grow and become more aggressive, Johns Hopkins urologists have found that reduction of a specific protein is correlated with the aggressiveness of prostate cancer, acting as a red flag to indicate an increased risk of cancer recurrence. Their findings are reported online in the Proceedings of the National Academy of Sciences on Aug. 27, 2012. http://medicalxpress.com/news/2012-08-team-biological-indicator-aggressive-recurrent.html Cancer Mon, 27 Aug 2012 18:14:37 EST news265310066 A new study shows that the lack of a certain gene occurs in almost 28 percent of human breast cancers, playing a role in some 60,000 breast cancer cases in the United States and 383,000 worldwide this year. http://medicalxpress.com/news/2012-08-gene-deletion-quarter-breast-cancers.html Genetics Wed, 15 Aug 2012 04:17:35 EST news264223029 Individuals with mutations in BRCA1 and BRCA2 genes have a significantly higher risk of developing breast and ovarian cancers. Families at risk have been seeking genetic testing and counseling based on their mutation carrier status, but the standard method of direct sequencing is labor-intensive, costly, and it only targets a part of the BRCA1 and BRCA2 genes. A group of Canadian scientists has developed a new sequencing approach to provide a more effective method of BRCA1/2 mutational analysis. Their work is published in the September issue of The Journal of Molecular Diagnostics. http://medicalxpress.com/news/2012-08-method-fast-accurate-analysis-brca.html Cancer Mon, 06 Aug 2012 00:00:01 EST news263386783 In the largest study of its kind, researchers have profiled genetic changes in cancer with drug sensitivity in order to develop a personalised approach to cancer treatments. The study is published in Nature on Thursday 29 March 2012. http://medicalxpress.com/news/2012-03-path-personalized-cancer-treatment.html Cancer Wed, 28 Mar 2012 13:00:03 EST news252151008 Scientists from Brigham and Women's Hospital and Dana-Farber Cancer Institute and their colleagues have found a genetic marker that predicts which aggressive "triple negative" breast cancers and certain ovarian cancers will likely respond to platinum-based chemotherapies. http://medicalxpress.com/news/2012-03-dna-marker-platinum-drug-response.html Cancer Thu, 22 Mar 2012 10:48:26 EST news251632099 Cancer Research UK scientists have succeeded in purifying a protein found in bacteria that could reveal new drug targets for inherited breast and ovarian cancers - and other cancers linked to DNA repair faults. The study is published in the journal Nature yesterday. http://medicalxpress.com/news/2011-09-bacteria-drug-inherited-cancers.html Cancer Tue, 06 Sep 2011 09:49:38 EST news234521369 Dose-dense chemotherapy has shown promise in smaller clinical trials, and now is being investigated in a multi-center, phase III study in which nearly 700 women will participate. Earlier phase II trials pointed to anti-cancer effects for the treatment approach, even when ovarian cancers had become resistant to standard treatment. http://medicalxpress.com/news/2011-06-ovarian-cancer-outcomes-dose-dense-chemotherapy.html Cancer Thu, 30 Jun 2011 09:23:51 EST news228644565 BOSTON--Researchers at Dana-Farber Cancer Institute have demonstrated a molecular strategy they say could make a much larger variety of tumors treatable with PARP inhibitors, a promising new class of cancer drugs. http://medicalxpress.com/news/2011-06-blocking-molecular-cancers-treatable-parp.html Cancer Wed, 29 Jun 2011 15:22:50 EST news228579697 Women with ovarian cancer could be helped by a new test that identifies the specific type of tumour they have, a conference will hear this week. http://medicalxpress.com/news/2011-05-treatment-ovarian-cancer-patients.html Cancer Tue, 31 May 2011 10:20:29 EST news226056014 A new treatment regimen for patients with metastatic colon cancer appears to offer clinical benefit even when used after multiple other treatments have failed, say research physicians at Georgetown Lombardi Comprehensive Cancer Center, a part of Georgetown University Medical Center. http://medicalxpress.com/news/2011-05-treatment-regimen-clinical-benefit-advanced.html Cancer Wed, 18 May 2011 18:20:10 EST news224961596