http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. (HealthDay)—There appears to be no association between persistent pulmonary hypertension of the newborn (PPHN) and gestational exposure to nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, according to a study published online Dec. 3 in Pediatrics. http://medicalxpress.com/news/2012-12-fetal-nsaid-exposure-tied-persistent.html Pediatrics Mon, 03 Dec 2012 16:59:13 EST news273776344 (HealthDay)—There is increasing evidence that the small airways contribute significantly to the clinical expression and severity of asthma, according to research published online Nov. 9 in Allergy. http://medicalxpress.com/news/2012-11-evidence-small-airway-role-asthma.html Immunology Tue, 20 Nov 2012 17:10:02 EST news272652446 (HealthDay)—Patients with advanced solid tumors receiving cisplatin-based chemotherapy regimens have a significantly higher risk of having a venous thromboembolic event (VTE) compared with those who do not receive a cisplatin-based regimen, according to research published online Nov. 13 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-11-venous-thromboembolism-cisplatin-based-chemo.html Cancer Thu, 15 Nov 2012 06:20:01 EST news272175326 (HealthDay)—For patients with cancer, statin use prior to diagnosis correlates with reduced all-cause and cancer-related mortality, according to a study published in the Nov. 8 issue of the New England Journal of Medicine. http://medicalxpress.com/news/2012-11-statin-cancer-diagnosis-linked-mortality.html Cancer Thu, 08 Nov 2012 11:20:01 EST news271593372 (HealthDay)—For women with operable breast cancer, moderate immunohistochemical expression of human epidermal growth factor receptor (HER)-2 (2+) without amplification of HER-2 (HER-2 2+/HER-2−) is an adverse prognostic factor, according to a study published online Sept. 4 in The Oncologist. http://medicalxpress.com/news/2012-10-adverse-prognostic-factor-idd-breast.html Cancer Tue, 30 Oct 2012 16:30:01 EST news270831740 (HealthDay)—The increase in total body fat and abdominal fat seen at menopause is due to the hormonal changes taking place, which can be improved by estrogen treatment, according to a study published in the October issue of Climacteric. http://medicalxpress.com/news/2012-10-hormonal-menopause-abdominal-obesity.html Overweight and Obesity Wed, 24 Oct 2012 16:20:12 EST news270313510 In a new perspective piece being published Online First tonight in Annals of Internal Medicine, a physician recalls lessons learned from treating patients affected by the 2002 outbreak of Exophiala (Wangiella) dermatitidis meningitis or arthritis related to contaminated, injectable coticosteroids prepared from a compounding pharmacy. http://medicalxpress.com/news/2012-10-dont-fungal-meningitis-outbreak.html Diseases, Conditions, Syndromes Thu, 18 Oct 2012 17:24:21 EST news269799853 (HealthDay)—A prescription medication originally developed to treat epilepsy may help obese adults shed weight when combined with routine nutritional counseling, researchers say. http://medicalxpress.com/news/2012-10-zonisamide-mg-weight-loss-obese.html Overweight and Obesity Tue, 16 Oct 2012 04:23:33 EST news269580204 (HealthDay)—Unsuspected pulmonary embolism (UPE) is not associated with an increased risk of death in cancer patients when compared to patients without pulmonary embolism (PE), according to research published in the October issue of the Journal of Thrombosis and Haemostasis. http://medicalxpress.com/news/2012-10-unsuspected-pe-seldom-linked-death.html Cancer Tue, 09 Oct 2012 19:00:01 EST news269024229 (Medical Xpress)—Physicians are less likely to trust the results of clinical trials when they know those trials were funded by pharmaceutical companies, regardless of the quality of the research, a recent study in the New England Journal of Medicine shows. http://medicalxpress.com/news/2012-10-physicians-drugs-pharmaceutical-industry-funded-trials.html Medications Tue, 09 Oct 2012 09:35:13 EST news268994102 (HealthDay)—Data missing from clinical trials can undermine the credibility of those trials, and little attention has been focused on this issue until recently, experts say. http://medicalxpress.com/news/2012-10-limiting-problem-urged-clinical-trials.html Medical research Thu, 04 Oct 2012 05:40:01 EST news268546583 (HealthDay)—An initial watch-and-wait strategy does not have a detrimental effect on the freedom from treatment failure (FFTF) or overall survival rate in selected patients with low-tumor burden follicular lymphoma compared with patients initially treated with rituximab-containing regimens, according to research published online Sept. 24 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-09-watch-and-wait-low-tumor-burden-follicular-lymphoma.html Cancer Wed, 26 Sep 2012 04:30:02 EST news267851052 (HealthDay)—For patients with metastatic colorectal cancer (mCRC), most patients are treated with chemotherapy, even if they express negative or marginal preferences, according to a study published online Sept. 12 in Cancer. http://medicalxpress.com/news/2012-09-patient-doesnt-affect-chemo-advanced.html Cancer Fri, 21 Sep 2012 13:13:45 EST news267452006 (HealthDay)—New evidence-based guidelines have been compiled on the management of fever and and neutropenia (FN) in children with cancer and/or who are undergoing hematopoietic stem-cell transplantation; the guidelines were published online Sept. 17 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-09-guidelines-issued-pediatric-fever-neutropenia.html Cancer Wed, 19 Sep 2012 18:20:01 EST news267296979 (AP)—Pharmaceutical industry heavyweights are teaming up to address a challenge that's long vexed drugmakers: how to improve the way experimental drugs are tested so they can get approved, and reach patients, faster. http://medicalxpress.com/news/2012-09-drugmakers-team.html Medications Wed, 19 Sep 2012 13:27:45 EST news267280061 (HealthDay) -- Adding dexamethasone to prochlorperazine on days two and three, following palonosetron and dexamethasone on day one, reduces delayed nausea (DN) in patients receiving chemotherapy containing a platinum-based drug or an anthracycline, according to research published online Aug. 20 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-08-prolonged-dexamethasone-nausea-chemo.html Cancer Wed, 22 Aug 2012 16:50:01 EST news264870982 (HealthDay) -- The reasons for discontinuation of commonly used treatments for psoriasis vary by treatment, according to a study published online July 30 in the Journal of the American Academy of Dermatology. http://medicalxpress.com/news/2012-08-discontinuation-vary-psoriasis-treatment.html Diseases, Conditions, Syndromes Fri, 10 Aug 2012 13:20:01 EST news263821987 (HealthDay) -- Treating patients with surgically unresectable metastatic colon cancer and an asymptomatic intact primary tumor with bevacizumab and infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) chemotherapy is a viable and safe option, according to research published online Aug. 6 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-08-nonoperative-approach-feasible-advanced-colon.html Cancer Thu, 09 Aug 2012 11:42:53 EST news263731366 They say the real crisis stems from current incentives that reward companies for developing large numbers of new drugs with few clinical advantages over existing ones. http://medicalxpress.com/news/2012-08-crisis-drug-myth-experts.html Medications Tue, 07 Aug 2012 18:30:04 EST news263568436 (HealthDay) -- For patients with operable breast cancer, peripheral neuropathy due to adjuvant taxane therapy does not correlate with improved outcomes, according to research published online July 30 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-08-taxane-induced-neuropathy-tied-breast-cancer.html Cancer Thu, 02 Aug 2012 13:30:02 EST news263132377 (HealthDay) -- Etanercept treatment is well tolerated for psoriasis, with no indication of dose-related or cumulative toxicity in short- or long-term analyses, according to a study published in the August issue of the Journal of the American Academy of Dermatology. http://medicalxpress.com/news/2012-07-shortlong-term-analyses-deem-etanercept-safe.html Diseases, Conditions, Syndromes Sun, 29 Jul 2012 18:00:01 EST news262800490 (AP) — GlaxoSmithKline LLC will pay $3 billion and plead guilty to promoting two popular drugs for unapproved uses and to failing to disclose important safety information on a third in the largest health care fraud settlement in U.S. history, the Justice Department said Monday. http://medicalxpress.com/news/2012-07-glaxosmithkline-fined-3bn.html Other Mon, 02 Jul 2012 12:49:17 EST news260452152 (HealthDay) -- All patients with psoriasis should be screened for hepatitis B surface antigen and hepatitis B core antibody prior to the initiation of tumor necrosis factor-alpha inhibitor therapy, according to research published online June 25 in the Journal of the American Academy of Dermatology. http://medicalxpress.com/news/2012-07-hep-screening-urged-tnf-alpha-inhibitor.html Diseases, Conditions, Syndromes Sun, 01 Jul 2012 13:51:13 EST news260369467 (Medical Xpress) -- Australian scientists have overcome one of the most pressing problems facing the pharmaceutical industry – how to create antibodies that are stable enough to meet stringent requirements necessary for production in large quantities, injection into patients and long-term storage. http://medicalxpress.com/news/2012-06-stable-antibodies.html Medications Fri, 29 Jun 2012 06:48:53 EST news260171268 (HealthDay) -- A large proportion of patients with moderate-to-severe plaque psoriasis are underdiagnosed and undertreated for cardiovascular (CV) risk factors, according to a study published in the July issue of the Journal of the American Academy of Dermatology. http://medicalxpress.com/news/2012-06-psoriasis-patients-undertreated-cv-factors.html Diseases, Conditions, Syndromes Fri, 22 Jun 2012 10:40:01 EST news259577534 (HealthDay) -- Patients with psoriasis have significantly higher odds for having at least one of 14 other autoimmune diseases, according to a study published online June 4 in the Journal of the American Academy of Dermatology. http://medicalxpress.com/news/2012-06-psoriasis-tied-autoimmune-diseases.html Immunology Fri, 15 Jun 2012 14:30:01 EST news258983810 (HealthDay) -- For patients presenting with dyspnea, the additional measurement of B-type natriuretic peptide (BNP) levels increases the certainty of diagnosis of heart failure and accelerates initiation of appropriate treatment, but does not reduce medical costs, according to a study published online May 2 in the Journal of Internal Medicine. http://medicalxpress.com/news/2012-05-peptide-ups-diagnosis-heart-failure.html Cardiology Tue, 15 May 2012 13:55:11 EST news256308905 (HealthDay) -- Neither induction chemotherapy (ICT) nor high-dose radiation boost is associated with an improvement in five-year colostomy-free survival (CFS) in patients with locally advanced anal canal carcinoma (LAACC), according to a study published online April 23 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-04-benefit-induction-chemo-high-dose-boost.html Cancer Thu, 26 Apr 2012 12:40:01 EST news254659064 (HealthDay) -- The prevalence of older people with cancer using complementary medications as they start a chemotherapy regimen is 17 percent, and is associated with less advanced disease and higher functional status, according to a study published online Feb. 22 in Cancer. http://medicalxpress.com/news/2012-03-complementary-meds-percent-elderly-cancer.html Cancer Fri, 02 Mar 2012 12:42:01 EST news249914514 Prescriptions for narcotic painkillers soared so much over the last decade that by 2010 enough were being dispensed to medicate every adult in the United States around the clock for a month. http://medicalxpress.com/news/2012-02-networking-fuels-painkiller-boom.html Medications Mon, 20 Feb 2012 16:20:05 EST news248977195