http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. The herbal extract of a yellow-flowered mountain plant long used for stress relief was found to increase the lifespan of fruit fly populations by an average of 24 percent, according to UC Irvine researchers. http://medicalxpress.com/news/2013-06-herbal-boosts-fruit-lifespan-percent.html Medical research Tue, 18 Jun 2013 12:02:23 EST news290775734 A study by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences and the Department of Pharmacology at the University of California, San Diego, shows that a protein called MCL-1, which promotes cell survival, is essential for normal heart function. http://medicalxpress.com/news/2013-06-protein-essential-heart-function.html Genetics Mon, 17 Jun 2013 12:45:57 EST news290691951 When tumours metastasise, they can block lymphatic vessels, as researchers from ETH Zurich have discovered using a new method. The lymphatic fluid subsequently has to find a new path through the tissue. Such "detours" could well be the reason why metastasis misdiagnoses can occur in hospitals. http://medicalxpress.com/news/2013-05-lymphatic-fluid-detour.html Medical research Mon, 20 May 2013 07:18:59 EST news288253128 DNA, siRNA and miRNA can reprogram cancer cells – that is, if these nucleic acids could cross through the cell membrane. A University of Colorado Cancer Center study published today in the journal Therapeutic Delivery shows that cholesterol "rafts" can shepherd genetic payloads into cancer cells. http://medicalxpress.com/news/2013-04-cholesterol-rafts-drugs-cancer-cells.html Cancer Tue, 02 Apr 2013 08:15:36 EST news284109282 A national survey of health professionals showed that drug shortages are taking a heavy toll on cancer patients, forcing treatment changes and delays that for some patients meant worse outcomes, more therapy-related complications and higher costs. St. Jude Children's Research Hospital investigators played an important role in the study. http://medicalxpress.com/news/2013-03-cancer-drug-shortages-higher-greater.html Cancer Thu, 21 Mar 2013 11:40:03 EST news283084795 Humans have between 20,000 and 25,000 genes that carry instructions for assembling the proteins that do the work of cells. Work led by St. Jude Children's Research Hospital found that children who inherit certain variations in four particular genes are at much higher risk of developing acute lymphoblastic leukemia (ALL). http://medicalxpress.com/news/2013-03-inherited-genetic-variations-major-impact.html Cancer Tue, 19 Mar 2013 16:00:03 EST news282927521 A University of Colorado Cancer study published this week in the journal Carcinogenesis shows that bitter melon juice restricts the ability of pancreatic cancer cells to metabolize glucose, thus cutting the cells' energy source and eventually killing them. http://medicalxpress.com/news/2013-03-bitter-melon-juice-pancreatic-cancer.html Cancer Tue, 12 Mar 2013 13:48:12 EST news282314884 Like any factory, the body burns oxygen to get energy for its various needs. As a result, detrimental byproducts are released and our cells try to clean up shop with antioxidants. But as we age, this process becomes a losing battle. http://medicalxpress.com/news/2013-03-link-aging-autism-oxidation.html Medical research Mon, 04 Mar 2013 08:46:49 EST news281609200 Erxi Wu, assistant professor of pharmaceutical sciences, co-wrote the article, "Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells," which was published by Molecular Cancer Research, an American Association for Cancer Research journal.  http://medicalxpress.com/news/2013-03-mechanism-underlying-abdominal-pain-pancreatic.html Cancer Fri, 01 Mar 2013 08:36:53 EST news281349401 Even though costs for medications will continue to rise in 2013 by as much as 4 percent, the increase is projected to be less than in previous years, according to a report in the advance online publication of the American Journal of Health-System Pharmacy, the journal of the American Society of Health-System Pharmacists (ASHP). http://medicalxpress.com/news/2013-02-drug-hospitals-clinics.html Medications Mon, 18 Feb 2013 08:04:47 EST news280397048 Pancreatic cancer is a deadly disease with increased incidences in the recent years. According to NDSU researchers, epidemiological data show chronic stress in a negative social and psychological state such as depression might serve as a risk factor for cancer development and progression. However, the underlying biological mechanisms are not well understood.  http://medicalxpress.com/news/2013-02-link-stress-pancreatic-cancer-paper.html Cancer Fri, 15 Feb 2013 10:40:02 EST news280143750 (Medical Xpress)—Research that aims to rid dementia sufferers' brains of toxins could lead to a new treatment that reverses the symptoms of Alzheimer's disease in the future. http://medicalxpress.com/news/2013-02-dementia.html Alzheimer's disease & dementia Fri, 08 Feb 2013 06:00:02 EST news279524226 A pair of University of Colorado Cancer Center studies published this month show that the milk thistle extract, silibinin, kills skin cells mutated by UVA radiation and protects against damage by UVB radiation – thus protecting against UV-induced skin cancer and photo-aging. http://medicalxpress.com/news/2013-01-silibinin-thistle-uv-induced-skin-cancer.html Cancer Wed, 30 Jan 2013 14:46:37 EST news278779478 (Medical Xpress)—When the going gets tough, grape seed extract gets going: A University of Colorado Cancer Center study recently published in the journal Cancer Letters shows that the more advanced are colorectal cancer cells, the more GSE inhibits their growth and survival. On the other end of the disease spectrum, GSE leaves healthy cells alone entirely. http://medicalxpress.com/news/2013-01-colorectal-cancer-aggressive-treatment-grape.html Cancer Thu, 17 Jan 2013 10:48:15 EST news277642082 Exposing pregnant mice to low doses of the chemical tributyltin – which is used in marine hull paint and PVC plastic – can lead to obesity for multiple generations without subsequent exposure, a UC Irvine study has found. http://medicalxpress.com/news/2013-01-fetal-exposure-pvc-plastic-chemical.html Health Tue, 15 Jan 2013 00:00:08 EST news277404251 (Medical Xpress)—A high-fiber diet may have the clinical potential to control the progression of prostate cancer in patients diagnosed in early stages of the disease. http://medicalxpress.com/news/2013-01-high-fiber-diet-prostate-cancer.html Cancer Wed, 09 Jan 2013 16:04:17 EST news276969852 Researchers have discovered a new therapeutic target for diabetic nephropathy, the leading cause of kidney failure. The findings, appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN), could help protect the kidney health of individuals with diabetes. http://medicalxpress.com/news/2012-10-diabetic-kidney-disease-failure.html Diseases, Conditions, Syndromes Thu, 18 Oct 2012 17:00:01 EST news269791201 A new prototype for medicated chewing gum has been developed for motion sickness that may offer many advantages over conventional oral solid dosage forms. About 33 percent of people are susceptible to motion sickness in mild circumstances and 66 percent are affected in more severe conditions. This research is being presented at the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Chicago, Ill., Oct. 14 – 18, an international event anticipating more than 8,000 attendees. http://medicalxpress.com/news/2012-10-gum-motion-sickness.html Medications Wed, 17 Oct 2012 10:36:45 EST news269688997 A new compound created from a rich source in vegetables including broccoli and brussel sprouts has been developed to combat triple-negative breast cancer (TNBC). This research is being presented at the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in Chicago, Ill., on Oct. 14 – 18, during Breast Cancer Awareness Month. http://medicalxpress.com/news/2012-10-vegetable-derived-compound-effective-triple-negative-breast.html Cancer Wed, 17 Oct 2012 10:36:21 EST news269688963 In a study to investigate the detection by MRI of six kinds of positively-charged magnetic iron oxide nanoparticles designed to help monitor transplanted islet cells, a team of Japanese researchers found that the charged nanoparticles they developed transduced into cells and could be visualized by MRI while three kinds of commercially available nanoparticles used for controls could not. The study is published in a recent special issue of Cell Medicine [3(1)], now freely available on-line. http://medicalxpress.com/news/2012-10-mri-images-transplanted-islet-cells.html Medical research Mon, 01 Oct 2012 12:02:47 EST news268311760 Dr. Anglea Wandinger-Ness and Dr. Laurie Hudson were awarded a Provocative Questions grant to investigate the use of R-ketorolac against ovarian cancer. Ketorolac is an NSAID that the FDA approved for human use in 1991. They are investigating their hypothesis that R-ketorolac, and not S-ketorolac, acts on GTPases in the cell to control cell adhesion and growth in ovarian cancer cells. http://medicalxpress.com/news/2012-09-drug.html Medications Thu, 27 Sep 2012 13:44:25 EST news267972257 A team of Cardiff University scientists is leading new research to develop a vaccine against anthrax to help counteract the threat of bioterrorism. http://medicalxpress.com/news/2012-09-scientists-anthrax-vaccine-counteract-world.html Medical research Mon, 17 Sep 2012 10:35:27 EST news267096919 Not only infants crawl. ETH researchers have shown that so-called dendritic cells, important cells of the immune system, use a similar mode of movement more often than previously assumed. The scientists used intravital microscopy to image dendritic cells crawling within lymphatic vessels of living animals. http://medicalxpress.com/news/2012-08-preschool-lymphatic-vessels.html Medical research Thu, 09 Aug 2012 07:59:27 EST news263717954 (Medical Xpress) -- Sea anemones use venomous stinging tentacles to stun their prey, but one component of that venom is being used by researchers to treat the debilitating effects of Multiple Sclerosis (MS). http://medicalxpress.com/news/2012-07-sea-anemones-venom-key-multiple.html Immunology Mon, 23 Jul 2012 08:20:02 EST news262249081 Imagine millions of cancer cells organized in thousands of small divots. Hit these cells with drugs and when some cells die, you have a candidate for a cancer drug. But a review published this week in the journal Expert Opinion on Drug Discovery argues that these 2D models in fact offer very little information about a potential drug's effects in the body and may often give researchers misleading results. http://medicalxpress.com/news/2012-07-d-tumor-drug-discovery-success.html Medications Fri, 20 Jul 2012 10:06:09 EST news261997557 Pathological rage can be blocked in mice, researchers have found, suggesting potential new treatments for severe aggression, a widespread trait characterized by sudden violence, explosive outbursts and hostile overreactions to stress. http://medicalxpress.com/news/2012-06-hulk-anymore-scientists-block-excess.html Neuroscience Tue, 19 Jun 2012 17:00:16 EST news259341016 Erxi Wu, assistant professor of pharmaceutical sciences, and Shuang Zhou, a doctoral student in Wu’s lab, co-wrote the article, "Smilagenin Attenuates Beta Amyloid (25-35)-Induced Degeneration of Neuronal Cells via Stimulating the Gene Expression of Brain-Derived Neurotrophic Factor,” which will be published by Neuroscience. They collaborated with Yaer Hu lab at Shanghai Jiaotong University, China, for the publication. http://medicalxpress.com/news/2012-05-smilagenin-approach-neurodegeneration-disease.html Neuroscience Mon, 07 May 2012 06:33:43 EST news255591130 (Medical Xpress) -- Researchers at the University of California, San Diego, the Medical University of South Carolina, the University of Cincinnati, and American Life Science Pharmaceuticals of San Diego have validated the protease cathepsin B (CatB) as a target for improving memory deficits and reducing the pathology of Alzheimer's disease (AD) in an animal model representative of most AD patients. The study has been published in the online edition of the Journal of Alzheimer's Disease. http://medicalxpress.com/news/2012-03-drug-memory-mouse-alzheimer-disease.html Alzheimer's disease & dementia Wed, 07 Mar 2012 15:41:03 EST news250357244 Erxi Wu, assistant professor of pharmaceutical sciences, co-wrote the review article, “The paracrine Sonic Hedgehog signaling derived from tumor epithelial cells: A key regulator in the pancreatic tumor microenvironment,” which has been accepted by Critical Reviews in Eukaryotic Gene Expression.    http://medicalxpress.com/news/2012-02-ndsu-professor-publishes-paper-pancreatic.html Cancer Fri, 17 Feb 2012 05:24:01 EST news248678630 The body's control mechanisms for delivering zinc to cells could be key to improving treatment for some types of aggressive breast cancer. http://medicalxpress.com/news/2012-02-zinc-path-breast-cancer-treatment.html Cancer Mon, 06 Feb 2012 10:20:25 EST news247746020