http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. National Institutes of Health researchers used the popular anti-wrinkle agent Botox to discover a new and important role for a group of molecules that nerve cells use to quickly send messages. This novel role for the molecules, called SNARES, may be a missing piece that scientists have been searching for to fully understand how brain cells communicate under normal and disease conditions. http://medicalxpress.com/news/2013-05-botox-wrinkle-brain.html Medical research Thu, 02 May 2013 12:00:10 EST news286714608 A major factor in the advance of heart disease is the death of heart tissue, a process that a team of scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine think could be prevented with new medicines. Now, the researchers are one step closer to achieving that goal, thanks to their discovery of a key molecule in an unexpected place in heart cells – mitochondria, tiny energy factories that house the controls capable of setting off cells' self-destruct sequence. http://medicalxpress.com/news/2013-04-clues-heart-disease-unexpected.html Cardiology Fri, 12 Apr 2013 11:42:31 EST news284985742 Researchers of the Max Delbrück Center for Molecular Medicine (MDC) and the Leibniz Institute of Molecular Pharmacology (FMP) in Berlin-Buch, Germany, have now detected a substance that can prevent the accumulation of fluid in body tissue and thus edema formation. The results of Dr. Jana Bogum (MDC/FMP) from the MDC research group led by Professor Walter Rosenthal and PD Dr. Enno Klußmann could be important in the future for the treatment of excessive fluid retention in patients with chronic heart failure. Using a novel approach, the researchers have also discovered a new molecular mechanism controlling water homeostasis in the kidneys. http://medicalxpress.com/news/2013-04-edema-inhibitor.html Medical research Fri, 05 Apr 2013 11:21:20 EST news284379674 (Medical Xpress)—Scientists have discovered the powerful role the molecule Myosin VI plays in communication between nerve cells in the brain. http://medicalxpress.com/news/2013-02-molecule-key-sustaining-brain.html Medical research Mon, 04 Feb 2013 06:30:02 EST news279180996 Synapse development is promoted by a variety of cell adhesion molecules that connect neurons and organize synaptic proteins. Many of these adhesion molecules are linked to neurodevelopmental disorders; mutations in neuroligin and neurexin proteins, for example, are associated with autism and schizophrenia. According to a study in The Journal of Cell Biology, another family of proteins linked to these disorders regulates the function of neuroligins and neurexins in order to suppress the development of inhibitory synapses. http://medicalxpress.com/news/2013-01-protein-family-linked-autism-suppresses.html Medical research Mon, 28 Jan 2013 12:00:05 EST news278584054 Tumour cells need far more nutrients than normal cells and these nutrients cannot get into the malignant cells without transporters. http://medicalxpress.com/news/2013-01-scientist-cancer-therapy.html Cancer Thu, 24 Jan 2013 07:52:58 EST news278236367 Thyroid hormone resistance has been linked to mutations in the IGSF1 gene for the first time—surprising researchers who did not suspect it played a role in the maintenance of normal thyroid function. http://medicalxpress.com/news/2013-01-scientists-localise-genetic-mutations-responsible.html Genetics Wed, 16 Jan 2013 10:32:56 EST news277554769 (HealthDay)—Treating mice fed a high-fat diet with telmisartan reverses insulin resistance and glucose intolerance, but only when the peroxisome proliferator-activated receptor-δ (PPAR-δ) gene is present, according to a study published online Dec. 13 in Diabetes. http://medicalxpress.com/news/2013-01-telmisartan-reverses-insulin-resistance-mice.html Diabetes Thu, 03 Jan 2013 14:40:01 EST news276442581 A study in The Journal of Cell Biology identifies a motor protein that ferries HIV to the plasma membrane, helping the virus escape from macrophages. http://medicalxpress.com/news/2012-10-kinesin-chauffeur-hiv-destruction.html HIV & AIDS Mon, 22 Oct 2012 12:38:02 EST news270128268 (HealthDay)—Mutations in the X-linked immunoglobulin superfamily member 1 (IGSF1) gene, which encodes a pituitary-enriched plasma membrane glycoprotein, may play a role in central hypothyroidism, testicular enlargement, and variable prolactin deficiency, according to a study presented at the annual meeting of the American Thyroid Association (ATA), held from Sept. 19 to 23 in Montreal. http://medicalxpress.com/news/2012-09-ata-mutation-x-linked-gene-tied.html Genetics Tue, 25 Sep 2012 11:21:44 EST news267790872 Muscles have a pool of stem cells which provides a source for muscle growth and for regeneration of injured muscles. The stem cells must reside in special niches of the muscle for efficient growth and repair. http://medicalxpress.com/news/2012-09-timenew-insights-muscle-stem-cells.html Medical research Mon, 17 Sep 2012 10:32:50 EST news267096761 (HealthDay) -- A class of heart medications, cardiac glycosides, can induce immunogenic cell death (ICD), whereby dying cancer cells are converted into a vaccine that stimulates antitumor response, according to a study published in the July 18 issue of Science Translational Medicine. http://medicalxpress.com/news/2012-07-heart-medication-cancer-cells-vaccine.html Cancer Mon, 23 Jul 2012 09:55:13 EST news262256106 One of the marvels of brain development is the mass migration of nerve cells to their functional position. European research has investigated the molecules required for their successful navigation. http://medicalxpress.com/news/2012-07-brain-neurons.html Neuroscience Mon, 16 Jul 2012 09:36:51 EST news261650203 HER2 and its epidermal growth factor receptor cousins mobilize a specialized protein to activate a major player in cancer development and sugar metabolism, scientists report in the May 25 issue of Cell. http://medicalxpress.com/news/2012-05-skp2-cancer-promoting-glucose-processing-akt.html Cancer Fri, 25 May 2012 14:57:09 EST news257176616 Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology reveals how a lipid-converting enzyme helps the cells mobilize these integrins. http://medicalxpress.com/news/2012-01-dgk-alpha-cancer-cells-gain-traction.html Cancer Mon, 23 Jan 2012 13:16:08 EST news246546961 A team of researchers led by Kasturi Haldar and Souvik Bhattacharjee of the University of Notre Dame's Center for Rare and Neglected Diseases has made a fundamental discovery in understanding how malaria parasites cause deadly disease. http://medicalxpress.com/news/2012-01-notre-dame-fundamental-malaria-discovery.html Medical research Fri, 20 Jan 2012 14:33:26 EST news246292398 It's rubbed on the skin to reduce signs of aging and consumed by athletes to improve endurance but scientists now have the first evidence of one of vitamin E's normal body functions. http://medicalxpress.com/news/2011-12-scientists-innate-function-vitamin.html Medical research Tue, 20 Dec 2011 11:55:30 EST news243604509 Sluggish recycling of a protein-slicing enzyme could promote Alzheimer's disease, according to a study published online on November 21 in The Journal of Cell Biology. http://medicalxpress.com/news/2011-11-poor-recycling-bace1-enzyme-alzheimer.html Medical research Mon, 21 Nov 2011 12:00:03 EST news241097829 After eight years of work, researchers have unearthed what has been a well-kept secret of our immune system's success. The findings published online on June 9th in Immunity offer an explanation for how specialized immune cells are able to kill infected or cancerous cells without killing themselves in the process. http://medicalxpress.com/news/2011-06-killer-immune-cells.html Medical research Thu, 09 Jun 2011 14:02:57 EST news226846959