http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen's secondary activities so that it might work on more aggressive breast cancer. http://medicalxpress.com/news/2013-04-pathway-tamoxifen-aggressive-breast-cancer.html Cancer Tue, 23 Apr 2013 12:47:35 EST news285940047 Women who are pregnant or using synthetic progesterone birth control injections have a conspicuous vulnerability to certain infections including malaria, Listeria, HIV, and herpes simplex virus. A new research report appearing in the March 2013 issue of the Journal of Leukocyte Biology offers strong evidence for a possible explanation: the progesterone receptor, a pregnancy hormone sensor, targets a part of the immune system responsible for protection against these and other invaders. In addition to helping explain why some women are more vulnerable to certain infections, it also sheds light on why some autoimmune diseases, notably rheumatoid arthritis and multiple sclerosis, often go into remission during pregnancy. http://medicalxpress.com/news/2013-02-progesterone-pregnant-women-vulnerable-infections.html Medical research Thu, 28 Feb 2013 11:11:23 EST news281272260 Obese, postmenopausal women are at greater risk for developing breast cancer and their cancers tend to be more aggressive than those in lean counterparts. A University of Colorado Cancer Center study published in the December issue of the journal Cancer Research shows how this risk might be prevented. http://medicalxpress.com/news/2012-12-healthy-lifestyle-menopause-decrease-breast.html Cancer Wed, 19 Dec 2012 13:24:30 EST news275145864 A multicenter study led by researchers at UC Davis describes new, paradoxical characteristics of the most common type of breast cancer. The findings shed light on how the disease can evade treatment and could improve diagnosis and treatment of breast cancer. http://medicalxpress.com/news/2012-12-her2-paradox-her2-positive-stem-cells.html Cancer Fri, 14 Dec 2012 16:20:05 EST news274723407 (Medical Xpress)—Younger women who wait at least 15 years after their first menstrual period to give birth to their first child may reduce their risk of an aggressive form of breast cancer by up to 60 percent, according to a Fred Hutchinson Cancer Research Center study. The findings, by Christopher I. Li, M.D., Ph.D., a member of the Public Health Sciences Division at Fred Hutch, are published online in Breast Cancer Research and Treatment. http://medicalxpress.com/news/2012-12-childbirth-aggressive-breast-cancer-younger.html Cancer Wed, 12 Dec 2012 14:45:46 EST news274545794 Racial and ethnic disparities in breast tumor aggressiveness might be explained by social factors that influence the developing tumor and place those in disadvantaged groups at higher risk for aggressive breast cancer, according to data presented at the Fifth AACR Conference on The Science of Cancer Health Disparities, held here Oct. 27-30, 2012. http://medicalxpress.com/news/2012-10-socioeconomic-disadvantage-linked-breast-cancer.html Cancer Tue, 30 Oct 2012 06:30:45 EST news270797388 Breast-feeding reduces the risk for estrogen receptor-negative and progesterone receptor-negative breast cancer, according to a study conducted at Columbia University's Mailman School of Public Health. Researchers examined the association between reproductive risk factors—such as the number of children a woman delivers, breast-feeding and oral contraceptive use – and found an increased risk for estrogen receptor- and progesterone receptor- (ER/PR) negative breast cancer in women who do not breast-feed. The results also indicated that having three or more children without breast-feeding was associated with an increased risk for ER/PR-negative breast cancer. ER/PR-negative breast cancer often affects younger women and has a poor prognosis. http://medicalxpress.com/news/2012-10-breastfeeding-erpr-negative-breast-cancer.html Cancer Thu, 18 Oct 2012 13:47:53 EST news269786864 Research published in the July issue of The Journal of Nuclear Medicine shows imaging progesterone receptor (PR) status also may be able to identify responders and nonresponders to endocrine therapy at an early stage. Estrogen receptor-α (ERα) status is an important factor in determining the most appropriate treatment for breast cancer patients, especially for those who are ERα+ and likely to respond well to hormone-based, or endocrine, therapies. http://medicalxpress.com/news/2012-07-imaging-agents-breast-cancer-response.html Cancer Mon, 02 Jul 2012 12:09:00 EST news260449734 The histone de-acetylase (HDAC) inhibitor panobinostat is able to target and destroy triple negative breast cancer, reveals a new study published in BioMed Central's open access journal Breast Cancer Research. Researchers from Tulane University Health Sciences Center have shown that panobinostat was able to destroy breast cancer cells and reduce tumor growth in mice. http://medicalxpress.com/news/2012-05-blocking-dna-hdac-inhibitor-triple.html Cancer Mon, 21 May 2012 03:57:54 EST news256791449 American and Spanish researchers have found potential ways for doctors to improve the treatment of hormone receptor-positive breast cancer even if they lack access to costly multi-gene tests, as they report at the 4th IMPAKT Breast Cancer Conference. http://medicalxpress.com/news/2012-05-progesterone-receptor-hormone-receptor-positive-cancer.html Cancer Thu, 03 May 2012 11:30:03 EST news255261199 A recently presented study revealed that the bisphosphonate clodronate had a low incidence of adverse events and toxicity among patients with breast cancer and may modestly reduce the incidence of distant metastases in postmenopausal women. http://medicalxpress.com/news/2011-12-clodronate-safe-modestly-affected-breast.html Cancer Wed, 07 Dec 2011 16:22:24 EST news242497337 German researchers have identified an unexpected molecular marker that predicts how sensitive hard-to-treat triple-negative breast cancers are to chemotherapy. http://medicalxpress.com/news/2011-05-gene-chemotherapy-sensitivity-triple-negative-breast.html Cancer Thu, 05 May 2011 10:05:37 EST news223808703