http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Four proteins involved in translation, the final step of general protein production, are associated with poor prognosis in hormone-receptor-positive breast cancer when they are dysregulated, researchers reported at the AACR Annual Meeting 2012. http://medicalxpress.com/news/2012-04-pi3kmtor-pathway-proteins-tied-poor.html Cancer Sun, 01 Apr 2012 12:32:10 EST news252502306 (HealthDay) -- A new method of classifying invasive pulmonary adenocarcinomas, based on the predominant architecture developed by the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS), is a stage-independent predictor of survival, according to research published online March 5 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-03-lung-adenocarcinoma-architecture-survival.html Cancer Thu, 08 Mar 2012 16:30:01 EST news250442404 (HealthDay) -- Extensive intratumor heterogeneity, seen in samples obtained from renal carcinomas, may lead to underestimation of the tumor genomics based on single tumor-biopsy samples, according to a study published in the March 8 issue of the New England Journal of Medicine. http://medicalxpress.com/news/2012-03-intratumor-heterogeneity-renal-carcinomas.html Cancer Thu, 08 Mar 2012 05:00:02 EST news250403030 Family members of patients in the intensive care unit (ICU) tend to be overly optimistic about the possibility of recovery despite being told that the prognosis is grim, according to a study led by researchers at the University of Pittsburgh School of Medicine. The findings, reported in the March 6 issue of the Annals of Internal Medicine, indicate that family members try to sustain hope and harbor beliefs that their loved one will defy medical odds. http://medicalxpress.com/news/2012-03-family-members-icu-patients-optimistic.html Health Mon, 05 Mar 2012 17:00:02 EST news250166872 Patients with advanced heart failure should have ongoing conversations with their healthcare providers to make informed decisions about treatment options that match their personal values, goals and preferences, according to a scientific statement published in the American Heart Association journal, Circulation. http://medicalxpress.com/news/2012-03-difficult-discussions-ease-decisions-patients.html Cardiology Mon, 05 Mar 2012 16:00:26 EST news250167056 (HealthDay) -- Prognostic understanding and parental attitude are significant barriers to advance care discussions (ACD) for children with life-threatening conditions, according to a study published online March 5 in Pediatrics. http://medicalxpress.com/news/2012-03-barriers-pediatric-advance-discussions.html Other Mon, 05 Mar 2012 12:47:01 EST news250173982 Scientists at The University of Nottingham have used a revolutionary new DNA-reading technology for a research project that could lead to correct genetic diagnosis for muscle-wasting diseases. http://medicalxpress.com/news/2012-03-next-generation-dna-sequencing-diagnosis-muscular.html Medical research Mon, 05 Mar 2012 11:44:41 EST news250170265 (Medical Xpress) -- Scientists from the Friedrich Miescher Institute for Biomedical Research describe how the protein phosphatase SHP2 promotes breast cancer with poor prognosis. As they report in the latest issue of Nature Medicine, SHP2 is necessary for the maintenance of the few tumor initiating cells (TICs) in a breast tumor. These cells are thought to sustain the growth of the tumor, promote metastasis and lead to relapses. http://medicalxpress.com/news/2012-03-breast-cancer-poor-prognosis.html Cancer Mon, 05 Mar 2012 08:56:18 EST news250160154 Breast cancer represents about a fifth of all cancers diagnosed in women. The reasons for the rapid progression of the disease remain relatively poorly understood but recent work in the group of Veronika Sexl at the University of Veterinary Medicine, Vienna has pointed the finger strongly at loss or inactivation of the transcription factor STAT1. The results are published in the current issue of the journal Oncotarget. http://medicalxpress.com/news/2012-02-two-pronged-loss-stat1-bad-news.html Cancer Wed, 29 Feb 2012 09:10:13 EST news249729003 (Medical Xpress) -- Scientists at the University of Dundee studying an important tumour suppressor, which is involved in at least a quarter of all cancers, have uncovered new ways in which it works. http://medicalxpress.com/news/2012-02-uncover-cancer-suppressor.html Cancer Fri, 24 Feb 2012 06:37:48 EST news249287836 (HealthDay) -- A high vascular endothelial growth factor (VEGF) signaling score correlates with good prognosis in patients with early squamous cell carcinoma (SCC) of the lung, according to a study published online Feb. 21 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-02-high-vegf-score-tied-lung.html Cancer Wed, 22 Feb 2012 13:20:02 EST news249138565 Based on a study of nearly 2,000 breast cancer patients, researchers at the Swedish Cancer Institute in Seattle say that, in women between the ages of 40 and 49, breast cancers detected by mammography have a better prognosis. The study appears in the March issue of Radiology. http://medicalxpress.com/news/2012-02-mammography-detected-breast-cancer-year-olds.html Cancer Wed, 22 Feb 2012 05:30:03 EST news249109380 A new study reveals key factors that promote the spread of cancer to lymph nodes and provides a mechanism that explains how a common over-the-counter anti-inflammatory medication can reduce the spread of tumor cells through the lymphatic system. The research, published by Cell Press in the February 14 issue of the journal Cancer Cell, opens new avenues for the design of antimetastatic therapies. http://medicalxpress.com/news/2012-02-evidence-link-nsaids-cancer-metastasis.html Cancer Mon, 13 Feb 2012 14:00:01 EST news248362682 Breast cancers expressing the protein HER2 have a particularly poor prognosis. Treatment with trastuzumab (Herceptin) benefits some patients with HER2-positive breast cancer, but it is not as effective as had been hoped. Researchers are therefore seeking ways to enhance the effectiveness of trastuzumab. In this context, a team of researchers led by Ronald Levy, at Stanford University, Stanford, has identified a sequential treatment regimen that enhances the effectivenss of trastuzumab in xenotransplant models of breast cancer. http://medicalxpress.com/news/2012-02-effectiveness-breast-cancer-treatment.html Cancer Mon, 13 Feb 2012 13:37:37 EST news248362643 (AP) -- Trust your doctor? A survey finds that some doctors aren't always completely honest with their patients. http://medicalxpress.com/news/2012-02-mds-honest-patients.html Health Wed, 08 Feb 2012 17:33:50 EST news247944824 The American Society for Radiation Oncology (ASTRO) has developed a guideline on the radiotherapeutic and surgical management for newly diagnosed brain metastases. It has been published in Practical Radiation Oncology (PRO), ASTRO's official clinical practice journal. http://medicalxpress.com/news/2012-02-astro-brain-metastases-guideline.html Cancer Wed, 08 Feb 2012 11:03:57 EST news247921422 The drug oxaliplatin is a major reason the prognosis for metastatic colon cancer has gone from an expected survival of several months to a couple years. Unfortunately, the drug can also carry with it debilitating neurological side effects, which generally start as the sensation of pins and needles in fingers and toes and can leave patients unable to walk or dress independently. http://medicalxpress.com/news/2012-02-oxaliplatin-dose-neurological-side-effects.html Cancer Thu, 02 Feb 2012 13:22:32 EST news247411344 Glioblastoma multiforme (GBM) is the most common of all malignant brain tumors that originate in the brain. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies. New therapeutic approaches are therefore much needed. Joanna Phillips, Zena Werb, and colleagues, at the University of California, San Francisco, have now identified a potential new therapeutic target for the treatment of GBM. http://medicalxpress.com/news/2012-02-thought-provoking-therapeutic-brain-cancer.html Cancer Wed, 01 Feb 2012 13:13:53 EST news247324419 In the two largest clinical studies ever conducted on the molecular genetics of lung cancer, an international team led by scientists at the University of California, San Francisco (UCSF) has demonstrated that an available molecular test can predict the likelihood of death from early-stage lung cancer more accurately than conventional methods. The work may eventually help improve the odds of survival for hundreds of thousands of patients each year. http://medicalxpress.com/news/2012-01-lung-cancer-survival.html Cancer Thu, 26 Jan 2012 18:30:01 EST news246806867 Spanish researchers at CIC Biogune, the Cooperative Centre for Research into Biosciences and led by Dr. Maria Luz Martinez Chantar, have found a strong relationship between high levels of Hu antigen R (HuR) protein and the malignancy of Hepatocellular Carcinoma, through a novel molecular process in the investigation of this pathology and known as neddylation. The project provides new opportunities for making advances in the quest for personalised therapeutic applications in the treatment for Hepatocarcinoma. http://medicalxpress.com/news/2012-01-therapeutic-combat-liver-cancer.html Cancer Thu, 26 Jan 2012 09:58:00 EST news246794260 An investigational drug called regorafenib slowed the progression of tumors and lengthened the lives of patients with metastatic colorectal cancer, an international phase III clinical trial found. The findings were presented today at the Gastrointestinal Cancers Symposium of the American Society of Clinical Oncology in San Francisco by Mayo Clinic oncologist Axel Grothey, M.D., principal investigator of the trial in the United States. http://medicalxpress.com/news/2012-01-drug-survival-colorectal-cancer-patients.html Cancer Wed, 18 Jan 2012 03:47:37 EST news246080849 Melbourne researchers have discovered that acute myeloid leukaemia (AML), an aggressive blood cancer with poor prognosis, may be susceptible to medications that target a protein called Mcl-1. http://medicalxpress.com/news/2012-01-cell-death-achilles-heel-acute.html Genetics Tue, 17 Jan 2012 10:43:03 EST news246019373 Researchers have discovered that a subtype of leukemia characterized by a poor prognosis is fueled by mutations in pathways distinctly different from a seemingly similar leukemia associated with a much better outcome. The findings from the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project (PCGP) highlight a possible new strategy for treating patients with this more aggressive cancer. http://medicalxpress.com/news/2012-01-cancer-sequencing-potential-approaches-combat.html Cancer Wed, 11 Jan 2012 13:00:23 EST news245503237 A review of 16 prognostic indices used to predict risk of death in older adults in a variety of clinical settings, such as in nursing homes and hospitals, found that there is insufficient evidence to recommend the widespread use of these indices in clinical practice, according to a study in the January 11 issue of JAMA. http://medicalxpress.com/news/2012-01-accuracy-prognostic-tools-mortality-older.html Other Tue, 10 Jan 2012 17:00:01 EST news245436485 Sorafenib was effective in patients with non-small cell lung cancer and a KRAS mutation, but survival rates were reportedly "unsatisfactory," according to data presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy and Personalized Medicine, held Jan. 8-11, 2012. http://medicalxpress.com/news/2012-01-sorafenib-effective-patients-non-small-cell.html Cancer Tue, 10 Jan 2012 05:18:20 EST news245395092 A new study published in the Journal of Clinical Oncology shows that most patients who survive for at least five years after oesophageal cancer surgery recover an average quality of life. However, quality of life deteriorates significantly for one in six patients to a level that remains much lower than the average population in the five years after surgery. This suggests, say the researchers, that hospitals must be better at identifying this patient group. http://medicalxpress.com/news/2012-01-impaired-quality-life-oesophageal-cancer.html Cancer Wed, 04 Jan 2012 10:41:06 EST news244896048 Obesity doubles the risk of cancer recurrence and cancer-related death in patients with esophageal cancer who have been treated with surgery, researchers at Mayo Clinic found. Their 778-patient study, which appeared in the Dec. 1 issue of the Journal of Clinical Oncology, found that five-year survival in obese patients -- those with a body mass index of 30 or higher -- with esophageal cancer was 18 percent, compared to 36 percent in patients of normal weight. http://medicalxpress.com/news/2011-12-obesity-linked-higher-year-death.html Surgery Tue, 20 Dec 2011 13:16:18 EST news243609347 Dr. Alexander K. Smith hopes to provoke a national discussion about being frank with the very elderly about their individual medical prognosis. http://medicalxpress.com/news/2011-12-doctors-patients-realities-aging.html Health Fri, 16 Dec 2011 11:10:01 EST news243254104 Cancer researchers at Cold Spring Harbor Laboratory (CSHL) have carried out the first comprehensive study of the changes seen in the DNA of a patient with mast cell leukemia (MCL), an extremely aggressive subtype of acute myeloid leukemia (AML) with a very poor prognosis. http://medicalxpress.com/news/2011-12-comprehensive-dna-mast-cell-leukemia.html Cancer Fri, 16 Dec 2011 10:29:24 EST news243253753 In many cases, tumors suppress a patient's immune system in a way that keeps the cancer safe from immune system attack. This is particularly true for patients with glioblastoma, a primary brain tumor that carries a prognosis of only 12-15 months survival after diagnosis. http://medicalxpress.com/news/2011-11-arginine-t-cell-ability-cancer.html Cancer Tue, 22 Nov 2011 13:29:04 EST news241190914