http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Researchers headed by Erwin Wagner, the Director of the BBVA Foundation-CNIO Cancer Cell Biology Programme at the Spanish National Cancer Research Centre (CNIO), have deciphered how a stress-inducible gene regulator, AP-1, controls the survival of liver tumor-initiating cells. These results, published in the online edition of Nature Cell Biology, could provide new preventive strategies and identify potentially targetable molecules to prevent liver cancer. http://medicalxpress.com/news/2012-10-oncogenic-network-specific-liver-cancer.html Cancer Sun, 07 Oct 2012 14:01:41 EST news268837278 Prostate cancer is one of the most common cancers in men and early treatment is usually very successful. However, like other cancers, obesity increases the risk of aggressive prostate disease. New research, published in BioMed Central's open access journal BMC Medicine, finds that the fat surrounding the prostate of overweight or obese men with prostate cancer provides a favorable environment to promote cancer growth. http://medicalxpress.com/news/2012-09-obesity-prostate-cancer-gene.html Cancer Mon, 24 Sep 2012 19:00:01 EST news267705029 (Medical Xpress)—The p53 gene plays a key role in the prevention of cancer, by blocking cell growth and triggering programmed cell death or apoptosis. If, however, p53 has mutated and become defective, the cancer cells can acquire the ability to evade apoptosis and become more resistant to therapy. Researchers at Karolinska Institutet and Karolinska University Hospital have now obtained results from the first tests using a new substance that can restore the function of defective p53 and activate apoptosis in cancer cells. http://medicalxpress.com/news/2012-09-substance-cancer-cell-suicide.html Cancer Tue, 18 Sep 2012 09:42:44 EST news267180156 A mysterious form of cell death, coded in proteins and enzymes, led to a discovery by UNC researchers uncovering a prime suspect for new cancer drug development. http://medicalxpress.com/news/2012-09-cell-death-mystery-yields-cancer.html Cancer Thu, 13 Sep 2012 10:26:06 EST news266750756 A molecule that targets the cell's machinery for breaking down unneeded proteins can kill multiple myeloma cancer cells resistant to the frontline drug Velcade, researchers at Dana-Farber Cancer Institute have found. http://medicalxpress.com/news/2012-09-molecule-effectiveness-drug-resistant-myeloma.html Cancer Mon, 10 Sep 2012 12:00:04 EST news266491091 An unexpected discovery of how the body controls cell death has revealed a potential new therapeutic target. http://medicalxpress.com/news/2012-06-unexpected-discovery-highlights-role-cell.html Medical research Thu, 14 Jun 2012 18:18:43 EST news258916716 A study by Travis H. Stracker, researcher at the Institute for Research in Biomedicine (IRB Barcelona), in collaboration with scientists at the Memorial Sloan Kettering Cancer Center (MSKCC) in New York, reveals new information about the origin of tumors. http://medicalxpress.com/news/2012-06-uncover-clues-cancer.html Cancer Wed, 06 Jun 2012 10:41:35 EST news258198088 The histone de-acetylase (HDAC) inhibitor panobinostat is able to target and destroy triple negative breast cancer, reveals a new study published in BioMed Central's open access journal Breast Cancer Research. Researchers from Tulane University Health Sciences Center have shown that panobinostat was able to destroy breast cancer cells and reduce tumor growth in mice. http://medicalxpress.com/news/2012-05-blocking-dna-hdac-inhibitor-triple.html Cancer Mon, 21 May 2012 03:57:54 EST news256791449 The widely used diabetes medicine metformin can have protective effects on the heart, reveals a new study conducted at the Sahlgrenska Academy, at the University of Gothenburg, Sweden. http://medicalxpress.com/news/2012-03-diabetes-drug-heart-disease.html Diabetes Mon, 26 Mar 2012 09:29:30 EST news251972960 Researchers at Moffitt Cancer Center in Tampa, Fla., have discovered that the immune response regulator IKBKE (serine/threonine kinase) plays two roles in tobacco-related non-small cell lung cancers. Tobacco carcinogens induce IKBKE and, in turn, IKBKE induces chemotherapy resistance. http://medicalxpress.com/news/2012-02-important-role-tobacco-related-lung-cancers.html Cancer Thu, 09 Feb 2012 12:55:37 EST news248014519 Melatonin, best known for its role in sleep regulation, delayed the onset of symptoms and reduced mortality in a mouse model of Huntington's disease, say researchers at the University of Pittsburgh School of Medicine and Harvard Medical School. Their findings, published today in the Journal of Neuroscience, show for the first time that certain receptors for the hormone reside in the mitochondria, and that there are fewer of them both in affected mice and human brains. http://medicalxpress.com/news/2011-10-melatonin-onset-deaths-mouse-huntington.html Neuroscience Tue, 11 Oct 2011 17:34:40 EST news237573257 Researchers from the Walter and Eliza Hall Institute have for the first time identified a 'programmed cell death' pathway in parasitic worms that could one day lead to new treatments for one of the world's most serious and prevalent diseases. http://medicalxpress.com/news/2011-09-worm-cell-death-discovery-drugs.html Medical research Wed, 28 Sep 2011 09:59:43 EST news236422774 Cardiologists who perform heart operations using x-ray guided catheters are exposed to ionising radiation at levels two to three times higher per year than those experienced by radiologists. Now, new research has found the first evidence that these constant, high levels of exposure cause changes at cell level that might represent the body's way of protecting itself against the harmful effects of radiation. http://medicalxpress.com/news/2011-08-physicians-exposure-prompt-cellular-body.html Other Wed, 24 Aug 2011 04:10:24 EST news233376865 EU-funded researchers have made good progress in understanding how cancer cells can sometimes resist the effects of chemotherapy. This new knowledge will move forward the development of increasingly effective cancer treatments and could go some way to reducing relapse, good news for cancer patients and scientists alike. http://medicalxpress.com/news/2011-07-latest-cancer-cells-react-chemotherapy.html Cancer Thu, 14 Jul 2011 09:30:03 EST news229853666 Overweight or obese women with less-than-optimal levels of vitamin D who lose more than 15 percent of their body weight experience significant increases in circulating levels of this fat-soluble nutrient, according to a new study by researchers at Fred Hutchinson Cancer Research Center. http://medicalxpress.com/news/2011-05-percent-body-weight-significantly-boosts.html Overweight and Obesity Wed, 25 May 2011 16:11:41 EST news225558446 The anti-inflammatory drug celecoxib may be a useful additional treatment for people with breast cancer, Dutch researchers report at the IMPAKT Breast Cancer Conference in Brussels. http://medicalxpress.com/news/2011-05-anti-inflammatory-drug-breast-cancer.html Cancer Thu, 05 May 2011 10:01:54 EST news223808489 Researchers at The Wistar Institute have found a new way to force cancer cells to self-destruct. Low doses of one anti-cancer drug currently in development, called Gamitrinib, sensitize tumor cells to a second drug, called TRAIL, also currently in clinical development as part of an anticancer regimen. http://medicalxpress.com/news/2011-04-exploiting-stress-response-detonate-mitochondria.html Cancer Tue, 19 Apr 2011 17:04:55 EST news222451482