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(AP)—The U.S. Food and Drug Administration has approved a new injectable drug that uses radiation to treat advanced prostate cancer that has spread to the bones. http://medicalxpress.com/news/2013-05-radiation-based-prostate-cancer-drug.html Cancer Wed, 15 May 2013 16:31:37 EST news287854289 A new genetic test to gauge the aggressiveness of prostate cancer may help tens of thousands of men each year decide whether they need to treat their cancer right away or can safely monitor it. http://medicalxpress.com/news/2013-05-gene-prostate-cancer-treatment.html Genetics Wed, 08 May 2013 04:44:19 EST news287207046 An international group of investigators, led by researchers at Thomas Jefferson University's Kimmel Cancer Center, have solved the mystery of why a substantial percentage of castrate-resistant metastatic prostate cancer cells contain abnormally high levels of the pro-growth protein Stat5. They discovered that the gene that makes the protein is amplified—duplicated many times over—in these cancer cells, which allows them to produce excess amounts of the oncogenic protein. http://medicalxpress.com/news/2013-05-amplification-stat5-gene-excess-oncogenic.html Cancer Tue, 07 May 2013 17:46:53 EST news287167606 The lead investigator of a way to obtain images of prostate tumors and accurately diagnose them said Thursday that the new technology is the medical equivalent of a global positioning system for the prostate gland. http://medicalxpress.com/news/2013-05-gps-like-technology-prostate-tumors.html Cancer Fri, 03 May 2013 14:40:01 EST news286808361 Cancer cells are wily, well-traveled adversaries, constantly side-stepping treatments to stop their spread. But for the first time, scientists at the University of Michigan have decoded the molecular chatter that ramps certain cancer cells into overdrive and can cause tumors to metastasize throughout the body. http://medicalxpress.com/news/2013-04-decoded-molecular-messages-prostate-breast.html Cancer Tue, 30 Apr 2013 13:21:41 EST news286546894 Cancer is typically thought to develop after genes gradually mutate over time, finally overwhelming the ability of a cell to control growth. But a new closer look at genomes in prostate cancer by an international team of researchers reveals that, in fact, genetic mutations occur in abrupt, periodic bursts, causing complex, large scale reshuffling of DNA driving the development of prostate cancer. http://medicalxpress.com/news/2013-04-periodic-genetic-mutations-prostate-cancer.html Cancer Thu, 25 Apr 2013 12:00:02 EST news286108913 A new analysis has found that the loss or amplification of particular DNA regions contributes to the development of prostate cancer, and that patients with two of these DNA changes have a high likelihood of dying from the disease. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study provides valuable information on the genetics of prostate cancer and offers insights into which patients should be treated aggressively. http://medicalxpress.com/news/2013-04-dna-linked-prostate-cancer-lethality.html Cancer Mon, 22 Apr 2013 00:00:01 EST news285790030 Prostate cancer doesn't kill in the prostate – it's only once the disease travels to bone, lung, liver, etc. that it turns fatal. Previous studies have shown that loss of the protein E-Cadherin is essential for this metastasis. A University of Colorado Cancer Center study published this week in the Journal of Biological Chemistry describes for the first time a switch that regulates the production of E-Cadherin: the transcription factor SPDEF turns on and off production, leading to metastasis or stopping it cold in models of prostate cancer. http://medicalxpress.com/news/2013-04-landmark-prostate-cancer-metastasis.html Cancer Tue, 02 Apr 2013 13:37:29 EST news284128641 Hormonal therapies can help control advanced prostate cancer for a time. However, for most men, at some point their prostate cancer eventually stops responding to further hormonal treatment. This stage of the disease is called androgen-insensitive or castration-resistant prostate cancer. In a study published March 18 in Cancer Cell, a team led by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) found a mechanism at play in androgen-insensitive cells that enables them to survive treatment. They discovered that a protein called Siah2 keeps a portion of androgen receptors constantly active in these prostate cancer cells. Androgen receptors—sensors that receive and respond to the hormone androgen—play a critical role in prostate cancer development and progression. http://medicalxpress.com/news/2013-03-prostate-tumors-resist-treatmentand.html Cancer Mon, 18 Mar 2013 12:00:04 EST news282825539 Researchers at the University of Hawai'i Cancer Center have uncovered a novel mechanism that may lead to more selective ways to stop cancer cells from spreading. Associate Professor Joe W. Ramos PhD, a cancer biologist at the UH Cancer Center and his team have identified the role of the protein RSK2 in cancer cell migration, part of the process of cancer metastasis. http://medicalxpress.com/news/2013-02-protein-cancer.html Cancer Tue, 26 Feb 2013 09:39:27 EST news281093941 (Medical Xpress)—A high-fiber diet may have the clinical potential to control the progression of prostate cancer in patients diagnosed in early stages of the disease. http://medicalxpress.com/news/2013-01-high-fiber-diet-prostate-cancer.html Cancer Wed, 09 Jan 2013 16:04:17 EST news276969852 (Medical Xpress)—Patients who have inherited a specific common genetic variant develop bladder cancer tumors that strongly express a protein known as prostate stem cell antigen (PSCA), which is also expressed in many pancreatic and prostate tumors, according to research at the National Institutes of Health. http://medicalxpress.com/news/2012-12-gene-variation-bladder-cancer-treatment.html Cancer Thu, 27 Dec 2012 15:52:04 EST news275845917 Scientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say the finding could lead to a new treatment for prostate cancers that are no longer controlled by hormone-blocking drugs. http://medicalxpress.com/news/2012-12-culprit-castration-resistant-prostate-cancer.html Cancer Thu, 13 Dec 2012 14:19:08 EST news274630741 (HealthDay)—The approved use of the drug Zytiga has been expanded to include treatment of men with late-stage, hormone therapy-resistant prostate cancer before they undergo chemotherapy, the U.S. Food and Drug Administration announced Monday. http://medicalxpress.com/news/2012-12-fda-oks-prostate-cancer-drug.html Medications Mon, 10 Dec 2012 17:20:04 EST news274379071 Ground-breaking research by a UCLA team of physicians and engineers demonstrates that prostate cancer can be diagnosed using image-guided targeted biopsy. http://medicalxpress.com/news/2012-12-prostate-biopsy-potential-diagnosis-cancer.html Cancer Mon, 10 Dec 2012 13:10:45 EST news274367345 Prostate cancer presents a dilemma for patients and the physicians who treat them. Which cancers are essentially indolent and present no risk and which are life threatening? Which can be watched and which need aggressive treatment? http://medicalxpress.com/news/2012-11-coup-tfii-prostate-cancer.html Cancer Wed, 28 Nov 2012 13:00:28 EST news273327643 Research out of Roswell Park Cancer Institute (RPCI) supports the adoption of a new biomarker to measure the aggressiveness of primary prostate tumors. A team of investigators from three institutions, led by Shahriar Koochekpour, MD, PhD, Associate Professor of Cancer Genetics, Urology and Oncology in RPCI's Department of Cancer Genetics, has for the first time produced data showing that levels of serum glutamate, a naturally occurring nonessential amino acid that plays a key role in cancer metabolism, are increased in patients with primary and metastatic prostate cancer. http://medicalxpress.com/news/2012-10-uncovers-biomarker-aggressiveness-prostate-cancer.html Cancer Wed, 24 Oct 2012 11:08:38 EST news270294897 (HealthDay)—Stop-and-start hormone-deprivation therapy for localized prostate cancer doesn't shorten overall survival compared to continuous treatments, and yields fewer side effects such as impotence and hot flashes, a large new study suggests. http://medicalxpress.com/news/2012-09-prostate-cancer-hormone-therapy-safe.html Cancer Wed, 05 Sep 2012 17:50:01 EST news266084839 (Medical Xpress) -- New research suggests that many men with prostate cancer do not need immediate treatment, especially if they have low PSA scores or low-risk tumors that are unlikely to grow and spread. http://medicalxpress.com/news/2012-07-men-prostate-cancer-early-surgery.html Cancer Thu, 19 Jul 2012 04:05:20 EST news261889508 Scientists at the Johns Hopkins Kimmel Cancer Center, working with Danish researchers, have developed a novel anticancer drug designed to travel -- undetected by normal cells -- through the bloodstream until activated by specific cancer proteins. The drug, made from a weedlike plant, has been shown to destroy cancers and their direct blood supplies, acting like a "molecular grenade," and sparing healthy blood vessels and tissues. http://medicalxpress.com/news/2012-07-molecular-grenade-drug-mediterranean-weed.html Cancer Mon, 09 Jul 2012 16:23:19 EST news261069791 A hormone-depleting drug approved last year for the treatment of metastatic prostate cancer can help eliminate or nearly eliminate tumors in many patients with aggressive cancers that have yet to spread beyond the prostate, according to a clinical study to be presented at the annual meeting of the American Society of Clinical Oncology (ASCO), June 1-5, in Chicago. http://medicalxpress.com/news/2012-05-hormone-depleting-drug-localized-high-risk-prostate.html Cancer Wed, 16 May 2012 18:00:05 EST news256405573 Humanity is on the constant search for improvements in cancer treatments, and the International Space Station has provided a microgravity platform that has enabled advancements in the cancer treatment process. http://medicalxpress.com/news/2012-05-cancer-treatment-delivery.html Cancer Fri, 04 May 2012 10:20:01 EST news255342449 A blood screening result that suggests prostate cancer is bound to provoke high anxiety - even though up to 80 percent of those findings turn out to be false positives. http://medicalxpress.com/news/2011-12-panels-gearing-prostate-cancer-screenings-cancer.html Cancer Wed, 28 Dec 2011 05:50:01 EST news244266628 An international team of researchers led by clinicians at Weill Cornell Medical College have discovered a genetic Achilles' heel in an aggressive type of prostate cancer -- a vulnerability they say can be attacked by a targeted drug that is already in clinical trials to treat other types of cancers. http://medicalxpress.com/news/2011-11-achilles-heel-lethal-prostate-cancer.html Cancer Thu, 17 Nov 2011 03:30:52 EST news240723012 An occasional nuisance men endure to check for prostate cancer, the digital rectal exam may have heightened importance for those who are obese. http://medicalxpress.com/news/2011-07-rectal-exams-benefit-obese-men.html Other Mon, 11 Jul 2011 13:34:02 EST news229610035 A new targeted therapy for prostate cancer halts tumor growth in animals with advanced prostate cancer that is resistant to hormone therapy, a new study finds. The results will be presented Saturday at The Endocrine Society's 93rd Annual Meeting in Boston. http://medicalxpress.com/news/2011-06-cancer-therapy-prostate-tumor-cells.html Cancer Mon, 06 Jun 2011 09:39:51 EST news226571975 The oral antifungal drug itraconazole, most commonly used to treat nail fungus, may keep prostate cancer from worsening and delay the need for chemotherapy in men with advanced disease. Details of the finding, from a clinical trial led by Johns Hopkins experts, are scheduled for presentation on Saturday, June 4 at the 2011 American Society of Clinical Oncology (ASCO) annual meeting (abstract #4532). http://medicalxpress.com/news/2011-06-antifungal-drug-chemo-advanced-prostate.html Cancer Thu, 02 Jun 2011 13:16:37 EST news226239375 Even when treated with hormone therapy to suppress tumor growth, obese men face an elevated risk of their prostate cancer worsening, researchers at Duke University Medical Center have found. http://medicalxpress.com/news/2011-05-obesity-linked-higher-prostate-cancer.html Cancer Sun, 15 May 2011 16:09:18 EST news224694537