https://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. In 2021, 61.2 million Americans ages 12 and older used illicit drugs, and more than 106,000 died from drug-involved overuse. Florida ranks second to California, with 5,300 annual overdose deaths, outpacing the national average by about 23 percent. Excessive alcohol use is the leading cause of preventable death in the United States and is associated with numerous health issues, including heart disease, cancer, and poor mental health. https://medicalxpress.com/news/2023-11-vivid-imagery-fuels-addiction-cravings.html Tue, 14 Nov 2023 15:41:04 EST news619198861 Coupons for tobacco products appear to have a big impact on relapse rates for smokers who have recently kicked the habit, researchers report. https://medicalxpress.com/news/2023-08-tobacco-company-coupons-odds-ex-smokers.html Fri, 25 Aug 2023 12:18:03 EDT news612184680 A targeted therapy for children with high-risk Hodgkin lymphoma (HL) was shown to significantly reduce relapse rates when tested in a large multicenter clinical trial conducted by the Children's Oncology Group (COG) and led by pediatric oncologists at Roswell Park Comprehensive Cancer Center, Children's Healthcare of Atlanta and Winship Cancer Institute of Emory University. By combining the targeted antibody-drug conjugate (ADC) brentuximab vedotin (BV) with the standard chemotherapy regimen, children were 10% less likely to relapse. The findings were published today in the New England Journal of Medicine (NEJM). https://medicalxpress.com/news/2022-11-pediatric-multicenter-therapy-high-risk-hodgkin.html Thu, 03 Nov 2022 04:24:54 EDT news586668286 Researchers developing treatments for addiction are turning to virtual reality and gaming to help patients overcome their lack of impulse control and decrease the relapse rates. https://medicalxpress.com/news/2022-03-therapeutic-digital-gaming-vr-level-up.html Tue, 29 Mar 2022 09:35:21 EDT news567765316 For patients with acute lymphoblastic leukemia (ALL) carrying the Philadelphia chromosome and whose disease relapsed after allogeneic hematopoietic stem cell transplantation (HCT), the two-year overall survival rate has nearly doubled from the period between 2000 and 2004 to the period between 2015 and 2019, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research. https://medicalxpress.com/news/2022-01-survival-patients-relapsed-hematopoietic-cell.html Wed, 12 Jan 2022 04:02:24 EST news561182538 A class of proteins that has generated significant interest for its potential to treat diseases, has for the first time, been shown to be effective in reducing relapse, or drug-seeking behaviors, in a preclinical study. https://medicalxpress.com/news/2018-08-smurf1-approach-cocaine-addiction-relapse.html Tue, 14 Aug 2018 16:27:16 EDT news453482793 (HealthDay)—The detection of molecular minimal residual disease is associated with increased relapse rates in acute myeloid leukemia (AML), according to a study published in the March 29 issue of the New England Journal of Medicine. https://medicalxpress.com/news/2018-03-molecular-minimal-disease-remission-aml.html Thu, 29 Mar 2018 11:50:02 EDT news441542410 A lack of support means many prisoners relapse back to smoking on release, despite many wanting to stay smokefree, a new study has found. https://medicalxpress.com/news/2018-02-prison.html Fri, 23 Feb 2018 09:10:01 EST news438599243 Testing for DNMT3A mutations in FLT3-ITD subgroup of AML patients at the point of diagnosis and post-chemotherapy could improve treatment and predict chances of relapse and survival rates respectively https://medicalxpress.com/news/2016-07-discovery-profiling-aml-patients-therapies.html Mon, 11 Jul 2016 06:13:58 EDT news387436427 Multiple sclerosis (MS) is an autoimmune disorder that results in demyelination of neurons. The FDA-approved drug fingolimod (Gilenya, FTY-720) modulates signaling by the bioactive lipid sphingosine-1-phosphate (S1P), which is linked to MS pathogenesis. Fingolimod treatment reduces relapse rates and neurologic disability in many individuals with MS; however, the drug is less effective in some patients. https://medicalxpress.com/news/2016-06-receptor-variation-fingolimod-efficacy-mouse.html Thu, 16 Jun 2016 09:37:16 EDT news385288629 While considerable advances have been made in understanding the biology and treatment of schizophrenia, patients and physicians continue to face tough challenges, says the 2015-16 winner of the University of Pennsylvania Edward A. Strecker, MD Award for outstanding contributions to the field of clinical psychiatry. https://medicalxpress.com/news/2016-05-opportunities-advancing-treatment-schizophrenia.html Thu, 19 May 2016 15:41:10 EDT news382891256 It has been called a pioneering strategy for treating opioid addiction, and has already been adopted in a small yet growing number of jails and prisons in the United States. Now, a clinical trial published in the journal Addiction by researchers at NYU Langone Medical Center finds that the extended-release medication naltrexone (XR-NTX) is associated with a significant decline in relapse rates for a group of mostly heroin-dependent men after their release from New York City jails. https://medicalxpress.com/news/2015-04-opioid-relapse-fall.html Tue, 14 Apr 2015 16:49:48 EDT news348248975 Children treated for moderate acute malnutrition—a condition suffered by an estimated 35 million children worldwide—experience a disturbingly high rate of relapse and even death in the year following treatment and recovery. https://medicalxpress.com/news/2015-02-approach-childhood-malnutrition-relapses-deaths.html Wed, 11 Feb 2015 08:00:06 EST news342861983 In patients with neuromyelitis optica spectrum disorder (NMOSD, an autoimmune inflammatory disease of the central nervous system similar to multiple sclerosis but even more debilitating), the immunosuppressant medication mycophenolate mofetil (MMF) appears to reduce the frequency of relapse, stabilize or improve disabilities and be well tolerated by patients. https://medicalxpress.com/news/2014-09-immunosuppressant-effect-central-nervous-disorder.html Mon, 08 Sep 2014 16:02:35 EDT news329410933 (HealthDay)—A smartphone application, or "app," designed to tackle addiction has helped recovering alcoholics stay sober or reduce their risky drinking, a new clinical trial reports. https://medicalxpress.com/news/2014-03-smartphone-app-recovery-treatment-alcoholism.html Wed, 26 Mar 2014 16:30:05 EDT news315070193 The addition of a monoclonal antibody called gemtuzumab combined with standard chemotherapy has been shown to significantly reduce the risk of relapse and increase rates of disease-free survival in pediatric patients with acute myeloid leukemia (AML). Post-treatment relapse rates are a major indicator of potential for long-term survival in children with the disease. https://medicalxpress.com/news/2013-12-treatment-significantly-relapse-children-aml.html Sun, 08 Dec 2013 11:26:12 EST news305724360 Among anesthesiology residents entering primary training from 1975 to 2009, 0.86 percent had a confirmed substance use disorder during training, with the incidence of this disorder increasing over the study period and the risk of relapse high, according to a study appearing in the December 4 issue of JAMA, a medical education theme issue. https://medicalxpress.com/news/2013-12-incidence-trend-substance-disorder-medical.html Tue, 03 Dec 2013 15:59:39 EST news305308763 About half of smokers seeking treatment for smoking cessation have a history of depression. Compared with smokers who are not depressed, those who suffer from a major depressive disorder (MDD) have greater difficulty quitting. https://medicalxpress.com/news/2013-09-varenicline-smokers-depression.html Mon, 16 Sep 2013 17:00:01 EDT news298548715 Giving men with testicular cancer a single dose of chemotherapy alongside radiotherapy could improve the effectiveness of treatment and reduce the risk of long-term side-effects, a new study reports. As many as 96% of men with testicular cancer now survive at least ten years from diagnosis (1), but more advanced forms need to be treated with combination chemotherapy – which can have serious long-term complications. Researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust have therefore been searching for new treatments that would reduce the risk of relapse after initial treatment and so spare as many men as possible from needing combination chemotherapy. https://medicalxpress.com/news/2013-08-chemotherapy-radiotherapy-testicular-cancer-long-term.html Fri, 16 Aug 2013 09:27:34 EDT news295864045 (HealthDay)—A patient with Crohn's disease is concerned about the attempt by the makers of adalimumab to prevent disclosure of trial data submitted during the drug's approval process, according to a personal view piece published online April 16 in BMJ. https://medicalxpress.com/news/2013-04-patient-lack-biological-drugs.html Thu, 18 Apr 2013 16:00:03 EDT news285517875 A potential new treatment for alcoholism called nalmefene is effective and safe for reducing alcohol consumption in alcohol dependent individuals, says a new study published this week in Biological Psychiatry. https://medicalxpress.com/news/2013-04-treatment-option-alcohol-consumption-abstinence.html Thu, 11 Apr 2013 06:02:42 EDT news284878955 People with multiple sclerosis (MS) who were treated with combination therapy did not see significant clinical benefit over those treated with single drug therapy, but combination therapy did reduce the development of new lesions, according to an international research team led by The Mount Sinai Medical Center. The findings, part of the largest-ever MS trial sponsored by the National Institutes of Health, are published in the March 11 issue of Annals of Neurology. https://medicalxpress.com/news/2013-03-combination-therapy-similar-clinical-benefit.html Mon, 11 Mar 2013 14:00:01 EDT news282228386 A recent clinical trial found that interferonβ-1a (INF) and glatiramer acetate (GA), two of the most commonly prescribed drugs for multiple sclerosis (MS), provide no additional clinical benefit when taken together. While findings published today in Annals of Neurology, a journal of the American Neurological Association and Child Neurology Society, suggest that taking both INF and GA together was not superior to GA monotherapy in reducing relapse risk; the combination therapy does appear to reduce new lesion activity and total lesion volume. https://medicalxpress.com/news/2013-03-common-ms-drugs-relapse.html Mon, 11 Mar 2013 12:45:09 EDT news282224703 (HealthDay)—Natalizumab may be safe in pediatric multiple sclerosis (MS) patients with highly active disease, according to a small study published online Feb. 18 in JAMA Neurology. https://medicalxpress.com/news/2013-02-natalizumab-teens-multiple-sclerosis.html Fri, 22 Feb 2013 16:10:01 EST news280765852 Lung and head and neck cancer patients who smoked before surgery are more likely to relapse than those who had quit before surgery, Moffitt Cancer Center researchers say. They found that smoking-relapse prevention interventions are needed immediately after surgery to help prevent relapse. https://medicalxpress.com/news/2013-01-cessation-successful-cancer-patients-surgery.html Wed, 23 Jan 2013 03:53:32 EST news278135604 (Medical Xpress)—Before all the excitement about embryonic stem cells, doctors were using hematopoetic – that is, blood-forming—stem cells. Hematopoetic stem cells can replenish all the types of cells in the blood, and are the centerpiece of transplantation as treatment for diseases such as multiple myeloma or leukemia. They can come from two different places: directly from the marrow of a donor's hip bone, or indirectly from the donor's blood after a drug nudges the stem cells out of the bone marrow. https://medicalxpress.com/news/2013-01-landmark-blood-stem-cell-transplant.html Fri, 04 Jan 2013 08:20:01 EST news276509199 A new study led by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) shows that preparing older acute myeloid leukemia (AML) patients for bone marrow transplants with a reduced intensity conditioning regimen appears to be associated with higher rates of disease-free survival relative to the more typical treatments usually given to such patients. The study was presented at the 2012 American Society of Hematology (ASH) Annual Meeting in Atlanta, GA. https://medicalxpress.com/news/2012-12-intensity-regimen-prior-marrow-transplant_1.html Mon, 10 Dec 2012 00:00:01 EST news274318904 Appropriately dosed hypofractionated radiotherapy was gentle on healthy tissues and effective in controlling local-regional early breast cancer, according to 10-year follow-up results from the U.K. Standardization of Breast Radiotherapy Trials (START), presented at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium. https://medicalxpress.com/news/2012-12-hypofractionated-radiotherapy-safe-effective-early.html Fri, 07 Dec 2012 10:40:03 EST news274095123 It's a sad but familiar scene near the grounds of many medical campuses: hospital-gowned patients, some toting rolling IV poles, huddled in clumps under bus shelters or warming areas, smoking cigarettes. https://medicalxpress.com/news/2012-11-habits-die-hard-cancer-patients.html Mon, 26 Nov 2012 12:50:15 EST news273156596 (Medical Xpress)—Researchers at Moffitt Cancer Center, concerned that women who quit smoking during their pregnancies often resume smoking after they deliver their baby, tested self-help interventions designed to prevent postpartum smoking relapse. https://medicalxpress.com/news/2012-09-relapse-healthy-mothers-babies.html Wed, 26 Sep 2012 10:24:56 EDT news267873851