http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Interim results of an EORTC intergroup trial have confirmed that adjuvant imatinib impacts short-term freedom from relapse in patients with localized, surgically resected, high/ intermediate-risk GIST. In the high-risk subgroup, a non-statistically significant trend in favor of the adjuvant arm was observed in terms of Imatinib failure-free survival. This new endpoint for the adjuvant setting, survival free from any failure of the first employed tyrosine kinase inhibitor, was designed to incorporate secondary resistance, currently the main factor adversely affecting prognosis of patients with advanced GIST. http://medicalxpress.com/news/2013-05-eortc-intergroup-trial-imatinib-failure-free.html Cancer Wed, 29 May 2013 11:00:03 EST news289043996 What is the reason for the widely reported fact that men are more likely than women to die of cancer? New evidence from population studies suggests that free testosterone could be a key driver of cancer aggressiveness in a broad range of solid tumors and sarcomas, not just gender-specific cancers, according to researchers at the Danbury Hospital Research Institute. The conclusions, published in PLOS One, are based on analyses of about 1.2 million cases from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) database. http://medicalxpress.com/news/2013-05-free-testosterone-cancer-aggressiveness.html Cancer Tue, 14 May 2013 06:48:09 EST news287732876 Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) hide within the worldwide human population. While dormant in the vast majority of those infected, these active herpesviruses can develop into several forms of cancer. In an effort to understand and eventually develop treatments for these viruses, researchers at the University of North Carolina have identified a family of human genes known as Tousled-like kinases (TLKs) that play a key role in the suppression and activation of these viruses. http://medicalxpress.com/news/2013-02-gene-suppresses-herpesviruses.html Medical research Wed, 13 Feb 2013 12:00:03 EST news279977803 Geneticists led by University of Utah Nobel Prize Laureate Mario R. Capecchi, Ph.D., have engineered mice that develop clear cell sarcoma (CCS), a significant step in better understanding how this rare and deadly soft tissue cancer arises. The mouse model also can potentially speed the development of drugs to target genes that must be activated for the cancer to form. http://medicalxpress.com/news/2013-02-mouse-cell-sarcoma.html Cancer Mon, 11 Feb 2013 12:00:04 EST news279802041 (HealthDay)—The Complexity Index in Sarcoma (CINSARC) and Genomic Index prognostic signatures are valid independent methods of assessing synovial sarcoma (SS) prognosis, according to a study published online Jan. 14 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2013-01-genomic-patterns-sarcoma.html Cancer Fri, 18 Jan 2013 13:10:01 EST news277736373 A novel technique that enables scientists to measure and document tumor-inducing changes in DNA is providing new insight into the earliest events involved in the formation of leukemias, lymphomas and sarcomas, and could potentially lead to the discovery of ways to stop those events. http://medicalxpress.com/news/2011-09-technique-events-tumor.html Cancer Thu, 29 Sep 2011 13:27:18 EST news236521626