http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A study that aimed to understand how the cancer drug everolimus helps overcome the resistance breast cancers can develop to trastuzumab has left researchers contemplating a puzzle. http://medicalxpress.com/news/2013-05-everolimus-trastuzumab-resistance-her-positive.html Cancer Thu, 02 May 2013 10:35:22 EST news286709710 Researchers have confirmed that the novel oral agent ARQ 092 inhibits the AKT pathway and has a manageable safety profile in patients with a variety of advanced solid tumors, according to phase I data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10. http://medicalxpress.com/news/2013-04-akt-pathway-inhibitor-arq-safety.html Cancer Tue, 09 Apr 2013 07:21:37 EST news284710890 Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich identify a novel signal transduction pathway, which activates the parkin gene and prevents stress-induced neuronal cell death. http://medicalxpress.com/news/2013-03-parkinson-disease-parkin-neuronal-cell.html Parkinson's & Movement disorders Fri, 01 Mar 2013 11:07:03 EST news281358185 Researchers at the University of California, San Diego School of Medicine have uncovered a new signal transduction pathway specifically devoted to the regulation of alternative RNA splicing, a process that allows a single gene to produce or code multiple types of protein variants. The discovery, published in the June 27, 2012 issue of Molecular Cell, suggests the new pathway might be a fruitful target for new cancer drugs. http://medicalxpress.com/news/2012-06-enzyme-therapeutic-cancer-drugs.html Cancer Thu, 21 Jun 2012 13:20:18 EST news259497122 A team of University of Hawaii Cancer Center scientists led by James Turkson, Ph.D. have created a new type of anti-cancer drug named BP-1-102. The drug, which can be orally administered, targets a key protein that triggers the development of many types of cancer including lung, breast and skin cancers. http://medicalxpress.com/news/2012-05-anti-cancer-drug.html Cancer Tue, 22 May 2012 09:58:33 EST news256899505 The research team led by Prof. Samuel Lo, Associate Head of the Department of Applied Biology and Chemical Technology, recently discovered that chronic exposure to low-dose methyl-mercury, an environmental contaminant commonly found in seafood, may increase the risk of developing neurodegenerative disease. http://medicalxpress.com/news/2011-08-chronic-exposure-methyl-mercury-neurodegenerative-disease.html Health Thu, 04 Aug 2011 07:00:01 EST news231658411 Protruding from the surface of cells in the body like whiskers are sugar chains, a biological structure often bound to lipids and proteins embedded in the cell membrane. Recent studies have shown that sugar chains exhibit a broad range of functions, including signal transduction between cells and across the cell membrane, as well as functional regulation of immunity and hormones. “From among the diverse functions of sugar chains, we focus on their association with disease,” says Naoyuki Taniguchi, group director of the Systems Glycobiology Research Group at the RIKEN Advanced Science Institute and a world-renowned researcher in sugar chains. “The ultimate goal of our research is to clarify the mechanisms of the onset of disease in terms of sugar chains, and to diagnose and treat disease using those mechanisms.” Taniguchi’s research is probing the frontiers of sugar chain science for the diagnosis and treatment of disease. http://medicalxpress.com/news/2011-06-exposing-potential-sugar-chains-diagnosis.html Medical research Mon, 20 Jun 2011 09:35:50 EST news227781339