http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. When women at high risk of breast cancer viewed a customized web-based decision guide about prevention options, they were more likely to make a choice about prevention and to feel comfortable with their choice, a new study finds. http://medicalxpress.com/news/2012-04-decision-uncertainty-breast-cancer.html Cancer Sun, 15 Apr 2012 13:33:27 EST news253715585 Studies exploring the relationship between soy consumption and breast cancer have been mixed, but new research introduces a new thought: Could women with breast cancer who began eating soy as an adult develop a tumor more resistant to treatment? http://medicalxpress.com/news/2012-04-links-breast-cancer-resistance-soy.html Cancer Mon, 02 Apr 2012 14:00:01 EST news252584540 At the time of diagnosis, the majority of breast cancers are categorized as estrogen-receptor positive, or hormone sensitive, which means their cancerous cells may need estrogen to grow. Patients with this type of cancer often respond favorably to treatments called aromatase inhibitors, like tamoxifen, which cause cell death by preventing estrogen from reaching the cancerous cells. Over time, however, the disease often becomes resistant to estrogen deprivation from the drugs—making treatment options more limited. http://medicalxpress.com/news/2012-04-scientists-key-protein-players-hard-to-treat.html Cancer Sun, 01 Apr 2012 14:39:48 EST news252509978 Two studies published March 6 in the Journal of the National Cancer Institute provide insights about the CYP2D6 genotype in postmenopausal breast cancer patients and represent a major step forward in understanding the usefulness of CYP2D6 testing for deciding whether or not a patient should receive adjuvant tamoxifen for treatment of early-stage breast cancer. Both studies found that CYP2D6 genotypes that were indicative of reduced activity of enzymes that metabolize tamoxifen did not predict clinical responsiveness to adjuvant tamoxifen therapy among postmenopausal women with early-stage breast cancer. One study also found that CYP2D6 genotypes of reduced enzyme activity were not linked with fewer tamoxifen-induced hot flushes in patients. http://medicalxpress.com/news/2012-03-cyp2d6-genotype-tamoxifen-benefit.html Cancer Tue, 06 Mar 2012 16:00:07 EST news250263753 Among postmenopausal women with hormone receptor-positive breast cancer, increasing age was associated with a higher risk of death from breast cancer, according to a study in the February 8 issue of JAMA. http://medicalxpress.com/news/2012-02-death-breast-cancer-higher-older.html Cancer Tue, 07 Feb 2012 16:29:01 EST news247854530 A key protein potentially involved in regulating breast cancer progression has been identified by researchers at Clarkson University in Potsdam, N.Y. Led by professor Costel Darie, the team worked to identify the binding partner of Tumor Differentiating Factor (TDF), a pituitary hormone that had previously been shown to reduce cancer progression in breast cancer cells. http://medicalxpress.com/news/2012-01-receptor-key-breast-cancer.html Cancer Fri, 13 Jan 2012 16:02:17 EST news245692913 (Medical Xpress) -- UCD researchers have identified a novel biomarker that can identify those women with breast cancer who will have a poor response to tamoxifen, one of the principle anti-hormone drugs used to treat the disease. This may allow clinicians to tailor the treatment of early stage breast cancer patients appropriately. http://medicalxpress.com/news/2011-12-personalising-chemotherapy-breast-cancer-treatment.html Cancer Thu, 15 Dec 2011 11:14:49 EST news243170074 The largest study to investigate the tolerability of the breast cancer drug tamoxifen in male breast cancer patients has shown that men stop taking their prescribed therapy early because of problems with side effects caused by the drug. http://medicalxpress.com/news/2011-11-male-breast-cancer-patients-tamoxifen.html Cancer Wed, 16 Nov 2011 05:16:22 EST news240642975 In the last three decades, thousands of women with breast cancer have taken the drug tamoxifen, only to discover that the therapy doesn't work, either because their tumors do not respond to the treatment at all, or because they develop resistance to it over time. Now researchers at the University of California, San Francisco (UCSF) have discovered the molecular basis for tamoxifen resistance and found a potential way to defeat it. http://medicalxpress.com/news/2011-11-hdac-inhibitor-resistance-common-breast.html Cancer Sun, 13 Nov 2011 12:19:19 EST news240409151 All cells in our body have a system that can handle cellular waste and release building blocks for recycling. The underlying mechanism is called autophagy and literally means "self-eating". Many cancer cells have increased the activity of this system and the increased release of building blocks equip the cancer cells with a growth advantage and can render them resistant towards treatment. http://medicalxpress.com/news/2011-10-small-molecules-starve-cancer-cells.html Cancer Sun, 09 Oct 2011 04:27:02 EST news237353211 Medical researchers at the University of Leeds have come a step closer to understanding how to stop breast cancers from coming back. http://medicalxpress.com/news/2011-09-resisting-breast-cancer.html Cancer Wed, 21 Sep 2011 11:06:32 EST news235821969 The toxicities associated with aromatase inhibitors (AIs) may explain the lack of overall survival improvement compared with tamoxifen, according to a study published August 22 in the Journal of The National Cancer Institute. http://medicalxpress.com/news/2011-08-toxicity-aromatase-inhibitors-lack-survival.html Cancer Mon, 22 Aug 2011 16:26:47 EST news233249178 For the first time, researchers at Seattle Cancer Care Alliance have demonstrated the feasibility of using serial positron emission tomography (PET) scans, using a special estrogen-containing isotope, to confirm the relative effectiveness of estrogen-blocking and estrogen-depleting therapy in patients with metastatic breast cancer. The results of the research are published online in Clinical Cancer Research. http://medicalxpress.com/news/2011-08-pet-scans-effectiveness-estrogen-blocking-drugs.html Cancer Thu, 18 Aug 2011 10:46:17 EST news232883156 Taking a leukemia chemotherapy drug may help breast cancer patients who don't respond to tamoxifen overcome resistance to the widely-used drug, new research from the Kimmel Cancer Center at Jefferson suggests. http://medicalxpress.com/news/2011-08-leukemia-drug-reverses-tamoxifen-resistance-breast.html Cancer Mon, 01 Aug 2011 12:30:06 EST news231417656 The benefits of using tamoxifen to prevent recurrence of breast cancer after surgery continue to accrue long after women stop taking the drug, a study led by Oxford University has found. http://medicalxpress.com/news/2011-07-drug-benefits-breast-cancer-deaths.html Cancer Fri, 29 Jul 2011 08:56:00 EST news231148543 (Medical Xpress) -- Can a gel applied to the skin of a woman's breast provide the same cancer-fighting benefits as a pill taken by mouth but reduce the side effects of the medicine? http://medicalxpress.com/news/2011-07-gel-cancer-tumors.html Cancer Fri, 08 Jul 2011 07:47:51 EST news229329999 Can a gel applied to the skin of a woman's breast provide the same cancer-fighting benefits as a pill taken by mouth but reduce the side effects of the medicine? http://medicalxpress.com/news/2011-06-topical-skin-gel-breast-cancer.html Cancer Fri, 24 Jun 2011 10:17:15 EST news228129398 Patterns of radiation usage in breast conserving therapy for women 70 years and older with stage I breast cancer are changing: more women are opting for radioactive implants and those with estrogen positive tumors are opting out of radiation therapy, according to an abstract being presented at the American Society of Clinical Oncology annual meeting in Chicago by Thomas Jefferson University Hospital researchers on Saturday, June 4. The abstract (#6094) received an ASCO Merit Award. http://medicalxpress.com/news/2011-06-emerging-trends-therapy-women-early.html Cancer Thu, 02 Jun 2011 17:26:54 EST news226254381 Researchers have identified a new protein involved in the development of drug resistance in breast cancer which could be a target for new treatments, they report today in the journal Nature Medicine. http://medicalxpress.com/news/2011-05-scientists-drug-breast-cancer.html Cancer Sun, 22 May 2011 13:00:22 EST news225287182 A recently discovered enzyme drives the production of a potent form of estrogen in human breast cancer tissue, researchers from the University of Illinois at Chicago College of Medicine have found. http://medicalxpress.com/news/2011-05-enzyme-breast-cancer-growth.html Cancer Wed, 18 May 2011 16:14:24 EST news224954046 Cancer researchers at the Kimmel Cancer Center at Jefferson and an international team of collaborators have discovered a biomarker in breast cancer that may help identify which women will respond to anti-estrogen therapy. http://medicalxpress.com/news/2011-05-marker-breast-cancer-patients-tamoxifen.html Cancer Wed, 18 May 2011 10:12:32 EST news224932338 Breast cancer is the second most common cancer among women, with more than 200,000 women diagnosed each year. Being exposed to estrogen over a long period of time is one factor that can increase a woman's risk of developing the disease. One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen. Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acids—abundant in fish—could be a safe and beneficial booster for tamoxifen therapy. http://medicalxpress.com/news/2011-04-fish-oil-boosts-responses-breast.html Cancer Wed, 06 Apr 2011 09:26:48 EST news221300794