http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Researchers from the Centre for Genomic Regulation (CRG) in Barcelona reprogramme lymphoma and leukaemia cells to halt their malignancy. Resulting cells remain benign even when no longer subjected to treatment and reduce likelihood of developing new tumours. http://medicalxpress.com/news/2013-04-cell-reprogramming-leukaemia-lymphoma.html Cancer Wed, 03 Apr 2013 07:50:47 EST news284194240 Researchers from the RIKEN Brain Science Institute report that they successfully used a virus vector to restore the expression of a brain protein and improve cognitive functions, in a mouse model of Alzheimer's disease. http://medicalxpress.com/news/2013-04-method-alzheimer-mice.html Alzheimer's disease & dementia Mon, 01 Apr 2013 09:20:38 EST news284026825 Transplantation of mesenchymal stem cells cultivated on the surface of nanofibrous meshes could be a novel therapeutic strategy against post-prostatectomy erectile dysfunction (ED), conclude the authors of a study which is to be presented at the 28th Annual EAU Congress later this week. http://medicalxpress.com/news/2013-03-stem-cells-transplantation-technique-high.html Medical research Fri, 15 Mar 2013 03:00:04 EST news282498950 Multi-peptide vaccination therapy combined with the low-dose steroid drug dexamethasone shows promise in treating chemotherapy-naive castration resistant prostate cancer (CRPC) patients. http://medicalxpress.com/news/2013-03-japanese-p2-potential-combined-vaccine.html Cancer Fri, 15 Mar 2013 03:00:03 EST news282499148 The RAS pathway is a cellular signaling pathway that regulates growth and development in humans. RASopathies are a group of diseases characterized by defects in RAS signaling. http://medicalxpress.com/news/2013-02-insight-rasopathy-associated-lymphatic-defects.html Diseases, Conditions, Syndromes Fri, 08 Feb 2013 12:00:04 EST news279542494 Columbia University Medical Center (CUMC) researchers have identified a protein trafficking defect within brain cells that may underlie common non-familial forms of Parkinson's disease. The defect is at a point of convergence for the action of at least three different genes that had been implicated in prior studies of Parkinson's disease. Whereas most molecular studies focus on mutations associated with rare familial forms of the disease, these findings relate directly to the common non-familial form of Parkinson's. The study was published today in the online edition of the journal Neuron. http://medicalxpress.com/news/2013-02-treatment-non-familial-parkinson.html Parkinson's & Movement disorders Wed, 06 Feb 2013 13:17:15 EST news279379025 Alzheimer's disease is the most common form of dementia, affecting over 35 million people worldwide. It is generally assumed that the clumping of beta-amyloid (Aß) protein causes neuronal loss in patients. Medication focuses on reducing Aß42, one of the most common proteins and the most harmful. University of Twente PhD student Annelies Vandersteen is refining the current approach. She explains: "The results of my research provide a broader understanding of the processes that lead to Alzheimer's disease and in this way may help to bring about new medication". http://medicalxpress.com/news/2012-12-alzheimer-disease-treatment.html Alzheimer's disease & dementia Fri, 14 Dec 2012 09:43:09 EST news274700548 A potential new therapeutic strategy for treating Fragile X syndrome is detailed in a new report appearing in the current issue of Biological Psychiatry, from researchers led by Dr. Lucia Ciranna at University of Catania in Italy. http://medicalxpress.com/news/2012-11-next-generation-treatments-fragile-syndrome.html Psychology & Psychiatry Thu, 29 Nov 2012 11:14:36 EST news273410066 Cedars-Sinai Heart Institute researchers have found in an initial clinical trial that a drug typically prescribed for erectile dysfunction or pulmonary hypertension restores blood flow to oxygen-starved muscles in patients with a type of muscular dystrophy that affects males, typically starting in childhood or adolescence. http://medicalxpress.com/news/2012-11-common-drug-reverses-effect-becker.html Medical research Wed, 28 Nov 2012 14:42:41 EST news273336154 A new study by an international team of investigators led by Dana-Farber Cancer Institute scientists is the first to demonstrate that chemotherapy and a new, targeted therapy work better in combination than chemotherapy alone in treating patients with the most common genetic subtype of lung cancer. http://medicalxpress.com/news/2012-11-success-therapy-common-non-small-cell.html Cancer Wed, 28 Nov 2012 13:35:43 EST news273332135 New research proves the validity of one of the most promising approaches for combating Alzheimer's disease (AD) with medicines that treat not just some of the symptoms, but actually stop or prevent the disease itself, scientists are reporting. The study, in the journal ACS Medicinal Chemistry Letters, also identifies a potential new oral drug that the scientists say could lead the way. http://medicalxpress.com/news/2012-10-evidence-easing-inflammation-brain-cells.html Alzheimer's disease & dementia Wed, 03 Oct 2012 14:50:25 EST news268494610 Personalized antiplatelet treatment leads to better outcomes than standard antiplatelet treatment in patients undergoing coronary stent implantation, according to results from the MADONNA study presented at ESC Congress 2012. http://medicalxpress.com/news/2012-08-personalized-antiplatelet-treatment-outcome-pci.html Cardiology Tue, 28 Aug 2012 11:09:49 EST news265370983 Researchers at Moffitt Cancer Center and colleagues have demonstrated that the inhibition of signal transducer and activator of transcription 3 (STAT3) in mouse models of mantle cell lymphoma (MCL), an aggressive and incurable subtype of B-cell non-Hodgkin lymphoma that becomes resistant to treatment, can harness the immune system to eradicate residual malignant cells responsible for disease relapse. http://medicalxpress.com/news/2012-07-potential-key-treatment-mantle-cell.html Cancer Wed, 18 Jul 2012 12:16:58 EST news261832609 Protein interactions outside breast cancer cells can send signals to the cancer cells to permanently stop proliferating, a new study showed in the School of Medicine at The University of Texas Health Science Center San Antonio. http://medicalxpress.com/news/2012-07-proteins-cancer-cells-potential-drug.html Cancer Mon, 09 Jul 2012 15:00:08 EST news261064329 A heart attack doesn't just damage heart muscle tissue by cutting off its blood supply, it also sets off an inflammatory cascade that worsens underlying atherosclerosis, actively increasing the risk for a future heart attack. These findings from a study receiving advance online publication in Nature suggest an important new therapeutic strategy for preventing heart attacks and strokes, both of which are caused when atherosclerotic plaques rupture and block important blood vessels. http://medicalxpress.com/news/2012-06-immune-response-heart-worsens-atherosclerosis.html Cardiology Wed, 27 Jun 2012 13:00:11 EST news260010607 A pair of recent studies describes how pancreatic cancer cells produce a protein that attracts the body's immune cells and tricks them into helping cancer cells grow. The research, published by Cell Press in the June 12th issue of the journal Cancer Cell, also reveals that blocking the protein may be an effective way to treat pancreatic cancer. http://medicalxpress.com/news/2012-06-pancreatic-cancer-immune.html Cancer Mon, 11 Jun 2012 12:00:03 EST news258632760 Scientists have discovered a new function for a protein that protects cells during injury and could eventually translate into treatment for conditions ranging from cardiovascular disease to Alzheimer's. http://medicalxpress.com/news/2012-06-newly-protein-function-cells-injury.html Medical research Thu, 07 Jun 2012 12:00:01 EST news258289123 (HealthDay) -- Although live head lice obtained from school-aged children in Paris remain susceptible to the insecticide malathion, approximately 14 percent have been found to be resistant to permethrin, suggesting a strong basis for future insecticide resistance, according to research published online May 24 in the Journal of the American Academy of Dermatology. http://medicalxpress.com/news/2012-06-lice-permethrin-resistance.html Diseases, Conditions, Syndromes Tue, 05 Jun 2012 13:01:07 EST news258120033 A new study describes a compound that selectively kills cancer cells by restoring the structure and function of one of the most commonly mutated proteins in human cancer, the "tumor suppressor" p53. The research, published by Cell Press in the May 15th issue of the journal Cancer Cell, uses a novel, computer based strategy to identify potential anti-cancer drugs, including one that targets the third most common p53 mutation in human cancer, p53-R175H. The number of new cancer patients harboring this mutation in the United States who would potentially benefit from this drug is estimated to be 30,000 annually. http://medicalxpress.com/news/2012-05-drug-cancer-cells-faulty-tumor.html Cancer Mon, 14 May 2012 12:00:02 EST news256208916 Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have shown that breast cancer cells that metastasize to the lung express a higher level of the protein peroxiredoxin 2 (PRDX2). The study suggests that the modulation of the levels of this protein could be a new therapeutic strategy to prevent lung metastases. The study results have been advanced in the online edition of the journal Oncogene. http://medicalxpress.com/news/2012-04-protein-pulmonary-metastases-breast-cancer.html Cancer Tue, 10 Apr 2012 10:09:10 EST news253271343 In a finding that may challenge popular notions of body fat and health, researchers at Beth Israel Deaconess Medical Center (BIDMC) have shown how fat cells can protect the body against diabetes. The results may lead to a new therapeutic strategy for preventing and treating type 2 diabetes and obesity-related metabolic diseases, the authors say. http://medicalxpress.com/news/2012-04-gene-fat-cells-therapeutic-diabetes.html Medical research Sun, 01 Apr 2012 13:00:10 EST news252494117 Antibodies, once touted as the "magic bullets" of cancer care, are now fulfilling that promise and more advances are on the way, say cancer researchers at the Georgetown Lombardi Comprehensive Cancer Center http://medicalxpress.com/news/2012-03-bright-future-antibody-cancer-therapy.html Cancer Thu, 15 Mar 2012 12:00:01 EST news251031418 A new study identifies specific cell-stress signaling pathways that link injury of the optic nerve with irreversible vision loss. The research, published by Cell Press in the February 9 issue of the journal Neuron, may lead to new strategies that will help to protect vulnerable neurons in the retina after optic nerve damage and diseases. http://medicalxpress.com/news/2012-02-stress-pathway-potential-therapeutic-vision.html Neuroscience Wed, 08 Feb 2012 12:00:01 EST news247918616 Since cancer cells grow indefinitely, it is commonly believed that senescence could act as a barrier against tumor growth and potentially be used as a way to treat cancer. A collaboration between a cancer biologist from the University of Milano, Italy, and two physicists, from the National Research Council of Italy and from Cornell University, has shown that cell senescence occurs spontaneously in melanoma cells, but does not stop their growth, which is sustained by a small population of cancer stem cells. The results, published in the open-access journal PLoS Computational Biology on January 19 explain why it is difficult to treat cancer cells by inducing senescence alone. http://medicalxpress.com/news/2012-01-cell-senescence-tumor-growth.html Cancer Thu, 19 Jan 2012 17:27:56 EST news246216467 Among patients with sub-optimal low-density lipoprotein cholesterol (LDL-C) or high-density lipoprotein cholesterol (HDL-C) levels, use of the drug evacetrapib alone or in combination with statin medications was associated with significant increases in HDL-C levels and decreases in LDL-C levels, according to a study appearing in the November 16 issue of JAMA, a theme issue on cardiovascular disease. The study is being released early online to coincide with its presentation at the American Heart Association Scientific Sessions. http://medicalxpress.com/news/2011-11-medication-hdl-cholesterol-decreases-ldl.html Medications Tue, 15 Nov 2011 10:31:12 EST news240575460 A promising cancer treatment drug can restore function of a heart en route to failure from high blood pressure, researchers at UT Southwestern Medical Center have found. http://medicalxpress.com/news/2011-05-drug-reverse-overgrown-hearts-heart.html Medical research Tue, 31 May 2011 03:49:20 EST news226032542 Tacrolimus, a drug that is commonly used to prevent organ transplantation rejection, inhibits breast cancer growth in pre-clinical studies. The finding from UNC scientists was reported in the May 26th PLoS ONE. http://medicalxpress.com/news/2011-05-common-transplant-drug-inhibits-breast.html Cancer Thu, 26 May 2011 13:45:19 EST news225636304