http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Four proteins involved in translation, the final step of general protein production, are associated with poor prognosis in hormone-receptor-positive breast cancer when they are dysregulated, researchers reported at the AACR Annual Meeting 2012. http://medicalxpress.com/news/2012-04-pi3kmtor-pathway-proteins-tied-poor.html Cancer Sun, 01 Apr 2012 12:32:10 EST news252502306 Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes progressive cognitive impairment and memory loss. Now, a new study published by Cell Press in the September 8 issue of the journal Neuron identifies a previously unrecognized link between neuroinflammation and the classical pathological brain changes that are the hallmark of the disease. In addition, the research identifies a new potential therapeutic target for AD. http://medicalxpress.com/news/2011-09-inflammatory-plaque-formation-alzheimer-disease.html Neuroscience Wed, 07 Sep 2011 13:01:25 EST news234619212 In a joint study, scientists from The Scripps Research Institute and Harvard University's Dana-Farber Cancer Institute have established a new class of anti-diabetic compound that targets a unique molecular switch. http://medicalxpress.com/news/2011-09-scientists-class-anti-diabetic-compound.html Medical research Sun, 04 Sep 2011 13:00:07 EST news234359780 The hormone receptor guanylyl cyclase C (GCC) has been established as a suppressor of colorectal cancer tumors, but new evidence from Thomas Jefferson University suggests it may also help fight one of the country's biggest pandemics: obesity. http://medicalxpress.com/news/2011-08-tumor-suppressor-obesity.html Medical research Thu, 25 Aug 2011 12:56:55 EST news233495785 New research suggests that blood stem cells can be involved in the generation of leukemia, even when the leukemia is caused by the abnormal proliferation of mature cells. The study, published by Cell Press in the August 16th issue of the journal Cancer Cell, may guide future strategies aimed at identifying therapeutic targets for chronic lymphocytic leukemia (CLL). http://medicalxpress.com/news/2011-08-stem-cells-central-pathogenesis-mature.html Cancer Mon, 15 Aug 2011 13:20:37 EST news232633216 Researchers at the University of Toronto, The Hospital for Sick Children (SickKids), St. Paul's Hospital and the University of British Columbia have identified a new treatment target for a virus that causes severe lung infections and an estimated 10% of common colds. http://medicalxpress.com/news/2011-08-pathway-infection-common-potentially-life-threatening.html Medical research Mon, 15 Aug 2011 11:08:34 EST news232625297 A biochemical pathway long associated with diarrhea and intestinal function may provide a new therapeutic target for treating ADHD (Attention Deficit Hyperactivity Disorder) other neuropsychiatric disorders, according to a team of scientists from China and the United States reporting Aug. 11 in Science. http://medicalxpress.com/news/2011-08-intestinal-protein-role-adhd-neurological.html Attention deficit disorders Thu, 11 Aug 2011 14:00:01 EST news232286782 Researchers at Memorial Sloan-Kettering Cancer Center and New York University have discovered how a mutation in the gene known as TET2 contributes to the development of some leukemias. When a mutation in TET2 occurs, it enhances the function of blood stem cells in the bone marrow, causing them to renew themselves more efficiently than normal blood stem cells. This results in a greater number of mutant cells than normal blood stem cells, a condition that leads to leukemia. http://medicalxpress.com/news/2011-07-gene-mutation-contributes-leukemia-function.html Cancer Fri, 01 Jul 2011 11:00:16 EST news228736795 New research confirms that a variant on the patatin-like phospholipase-3 (PNPLA3) gene increases risk of steatosis and fibrosis progression in patients with chronic hepatitis C virus (HCV). The PNPLA3 single nucleotide polymorphism (SNP) rs 738409 may represent an important genetic predictor and potential therapeutic target in chronic HCV liver damage. Study details are published in the July issue of Hepatology, a peer-reviewed journal of the American Association for the Study of Liver Diseases. http://medicalxpress.com/news/2011-06-gene-variant-fatty-liver-fibrosis.html Genetics Tue, 28 Jun 2011 10:45:37 EST news228476717 British researchers have identified specific resistance mutations for two classes of p7 inhibitor, which may explain their lack of effectiveness in clinical trials combined with current standard of care. Study results support the role of p7 inhibitor combinations as potential components of future HCV-specific therapies and are available in the July issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases. http://medicalxpress.com/news/2011-06-p7-protein-resistance-mutations-drug.html Diseases, Conditions, Syndromes Tue, 28 Jun 2011 10:41:00 EST news228476444 Diabetic kidney disease has become more prevalent in the United States over the past 20 years, despite a substantial increase in the use of medications for the treatment of people with diabetes, according to a study to be published June 22 in JAMA, the Journal of the American Medical Association. http://medicalxpress.com/news/2011-06-diabetic-kidney-disease-america-diabetes.html Diseases, Conditions, Syndromes Tue, 21 Jun 2011 16:21:38 EST news227892050 An international team of scientists led by researchers at the University of California, San Diego School of Medicine have used induced pluripotent stem cells (iPSCs) derived from patients with amyotrophic lateral sclerosis (ALS) to reveal for the first time how reduced levels of a specific protein may play a central role in causing at least one inherited form of the disease. http://medicalxpress.com/news/2011-06-stem-cell-clues-inherited-als.html Genetics Tue, 21 Jun 2011 16:04:02 EST news227891007 In a study recently published in Cancer Research, Van Andel Research Institute (VARI) researchers found a protein that could help predict the spread of the head and neck cancer nasopharyngeal carcinoma (NPC); this protein could also serve as part of a treatment strategy to stop the spread of the disease. http://medicalxpress.com/news/2011-06-potential-predictor-deadly-cancer-common.html Cancer Tue, 14 Jun 2011 17:24:18 EST news227291046 Researchers at King's College London have identified a way of eliminating leukaemic stem cells, which could lead to new treatments that may enable complete remission for leukaemia patients. An early study in mice has shown that leukaemic stem cells can be abolished by suppressing two proteins found in the body. http://medicalxpress.com/news/2011-06-stem-cell-treatment-leukemia-closer.html Cancer Thu, 02 Jun 2011 13:29:27 EST news226240134 A new study by motor control and psychology researchers at Indiana University suggests that postural control problems may be a core feature of bipolar disorder, not just a random symptom, and can provide insights both into areas of the brain affected by the psychiatric disorder and new potential targets for treatment. http://medicalxpress.com/news/2011-05-bipolar-disorder-mind-body-treatment.html Psychology & Psychiatry Tue, 24 May 2011 12:04:16 EST news225457425 (Medical Xpress) -- Researchers at the University of Toronto and the University of Bath have resolved a longstanding controversy surrounding an important structure of the immune system that could result in new therapeutic targets for antibody-mediated autoimmune diseases as well as the potential to enhance the efficacy of vaccines. http://medicalxpress.com/news/2011-05-important-immune-complex-year-controversy.html Medical research Wed, 04 May 2011 07:50:04 EST news223711894 One way of discovering a gene's function is to switch it off and observe how the loss of its activity affects an organism. If a gene is essential for survival, however, then switching it off permanently will kill the organism before the gene's function can be determined. Researchers at Cold Spring Harbor Laboratory (CSHL) have overcome this problem by using RNA interference (RNAi) technology to temporarily turn off any essential gene in adult mice and then turn it back on before the change kills the animals. http://medicalxpress.com/news/2011-04-team-non-lethal-essential-genes-mice.html Genetics Thu, 14 Apr 2011 10:07:25 EST news221994407