http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. An extensive genomic study of the childhood cancer neuroblastoma reinforces the challenges in treating the most aggressive forms of this disease. Contrary to expectations, the scientists found relatively few recurrent gene mutations—mutations that would suggest new targets for neuroblastoma treatment. Instead, say the researchers, they have now refocused on how neuroblastoma tumors evolve in response to medicine and other factors. http://medicalxpress.com/news/2013-01-tumors-evolve-rapidly-childhood-cancer.html Genetics Sun, 20 Jan 2013 13:00:27 EST news277901484 (Medical Xpress) -- A study published in Genes and Development from scientists at the Friedrich Miescher Institute for Biomedical Research pinpoints the importance of maternal epigenetic influences during early embryogenesis in mammals. A chromatin regulatory complex in the oocyte ensures that the proper luggage of maternal transcripts and chromatin structures control the first steps in the formation of an embryo. In the absence of this epigenetic regulator the embryo fails to develop correctly. http://medicalxpress.com/news/2012-05-mother-maternal-epigenetic-inheritance.html Genetics Mon, 07 May 2012 08:58:44 EST news255599878 GW Cancer Research Team in the Department of Biochemistry and Molecular Biology, in the School of Medicine and Health Sciences, published a study that is the first of its kind to use mRNA sequencing to look at the expression of genome, at a unprecedented resolution at the current time, in three types of breast cancer. The study titled, "Transcriptomic landscape of breast cancer through mRNA sequencing," is published in the Feb. 14 edition of the journal, Scientific Reports, a new open access Nature journal for large volume data. http://medicalxpress.com/news/2012-02-reveal-digital-transcriptome-breast-cancer.html Cancer Tue, 14 Feb 2012 11:39:25 EST news248441949 (Medical Xpress) -- By developing a large scale gene expression map for retinal cell types, FMI Neurobiologists have been able to identify the cells in the retina, where the genes causing retinal diseases specifically act. This narrows down the search for a better understanding of the diseases and opens up new avenues for therapeutic approaches. http://medicalxpress.com/news/2012-01-transcriptional-barcoding-retinal-cells-disease.html Neuroscience Mon, 23 Jan 2012 05:49:37 EST news246520165 The population of Eric Morrow's seminar "Neurogenetics and Disease" comprises mainly undergraduates who were skipping down the halls of their elementary schools when the first drafts of human genome sequences were published. When Morrow, assistant professor of biology, recently asked the class how to find the mutation behind a disease, a hand shot up in the back of the class to signal the answer: "Sequence the patient's genome." http://medicalxpress.com/news/2011-12-gene-mouse-neural-retina-sequenced.html Genetics Wed, 07 Dec 2011 13:06:36 EST news242485568 A first-of-its-kind study of a patient with lung cancer who never smoked will be presented today by TGen and the Virginia G. Piper Cancer Center at Scottsdale Healthcare at the 14th World Conference on Lung Cancer, July 3-7 in Amsterdam. http://medicalxpress.com/news/2011-07-whole-genome-lung-cancer-conference.html Cancer Wed, 06 Jul 2011 03:18:21 EST news229141086