http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A new class of investigational medicines may help to treat patients with cancers driven by mutations in genes such as BRAF or KRAS/NRAS, including those patients who have become resistant to therapies that target BRAF directly, according to preclinical data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10. http://medicalxpress.com/news/2013-04-preclinical-potential-inhibitor-drug-resistance.html Cancer Mon, 08 Apr 2013 09:20:04 EST news284629264 A team of UC Davis scientists has found that a product resulting from a metabolized omega-3 fatty acid helps combat cancer by cutting off the supply of oxygen and nutrients that fuel tumor growth and spread of the disease. http://medicalxpress.com/news/2013-04-fatty-acid-metabolite-cancer-mice.html Cancer Tue, 02 Apr 2013 16:19:15 EST news284138335 (Medical Xpress)—A research team jointly led by scientists from Cedars-Sinai Medical Center and the University of California, Los Angeles, have enhanced a device they developed to identify and "grab" circulating tumor cells, or CTCs, that break away from cancers and enter the blood, often leading to the spread of cancer to other parts of the body. http://medicalxpress.com/news/2013-04-diagnostic-technology-individualized-treatments-prostate.html Cancer Tue, 02 Apr 2013 08:14:04 EST news284109234 Investigators at the University of Granada have patented a melatonin gel that is 100% effective against this inflammatory reaction. http://medicalxpress.com/news/2013-02-scientists-technique-effectively-mucositis.html Cancer Thu, 14 Feb 2013 11:38:19 EST news280064259 A study led by Dr Josep Tabernero, the Director of Clinical Research at the Vall d'Hebron Institute of Oncology (VHIO) and Head of the Medical Oncology Department at the Vall d'Hebron University Hospital, shows for the first time that ribonucleic acid interference (RNAi) is effective in the treatment of cancer patients. Harnessing these molecules to silence genes involved in the development and growth of cancer cells is an important step forward in developing a new and more targeted type of cancer therapy. http://medicalxpress.com/news/2013-02-first-in-man-therapeutic-effect-rnai-gene.html Cancer Mon, 11 Feb 2013 08:46:49 EST news279794788 (HealthDay)—Early palliative care (PC) clinic visits, integrated with standard oncologic care for patients with metastatic lung cancer, emphasize symptom management, coping, and psychosocial aspects of illness, according to research published online Jan. 28 in JAMA Internal Medicine. http://medicalxpress.com/news/2013-01-early-palliative-lung-ca-focuses.html Health Wed, 30 Jan 2013 15:23:47 EST news278781819 From a single cell gone bad, cancer evolves into an increasingly complex tumor built of a variety of normal cells and diverse malignant cells, some of which escape to create dangerous colonies in other organs, further jumbling the treatment picture. http://medicalxpress.com/news/2013-01-capture-interrogate-cancer-cells-award.html Medical research Fri, 11 Jan 2013 09:14:25 EST news277118057 A collaboration between the Paul Scherrer Institute, CERN's ISOLDE facility, and the Institut Laue-Langevin, has published preclinical study results for a newly developed set of tumour-targeting radiopharmaceuticals. The results, published in The Journal of Nuclear Medicine, are a significant success for this group of nuclear medicine specialists and radiochemists, demonstrating the potential to provide a new generation of radioisotopes with excellent properties for the diagnosis and treatment of cancer. http://medicalxpress.com/news/2012-12-terbium-swiss-army-knife-cancer.html Cancer Mon, 24 Dec 2012 07:49:38 EST news275557766 Researchers from Inserm and CNRS from the Institute for genetics and molecular and cellular biology (IGBMC) and from the Research Institute at the Strasbourg school of biotechnology (Irebs) have focussed their efforts on PARG, currently thought to be a promising new therapeutic target in the treatment of cancer. Their work has revealed the role of this molecule in regulating gene expression. The results were published on 25 October 2012 in the on-line Molecular Cell review. http://medicalxpress.com/news/2012-10-reveal-molecule-function-terms-cancer.html Cancer Tue, 30 Oct 2012 12:10:02 EST news270815672 Researchers from Royal Holloway, University of London are looking at ways of testing the side effects of new drugs without using animals. http://medicalxpress.com/news/2012-10-animal-drug.html Medical research Wed, 10 Oct 2012 07:56:35 EST news269074590 (Medical Xpress)—Researchers at University of California, San Diego Moores Cancer Center are evaluating the safety and tolerability of a synthetic cannabinoid called dexanabinol (ETS2101). Delivered as a weekly intravenous infusion, the drug is being tested in patients with all forms of brain cancer, both primary and metastatic. http://medicalxpress.com/news/2012-09-clinical-trial-synthetic-cannabinoid-brain.html Cancer Wed, 26 Sep 2012 09:27:19 EST news267870387 The diagnosis and treatment of cancer does not only trigger posttraumatic stress disorder in adults and older children; infants and toddlers with cancer also suffer from trauma disorders, as researchers from the University of Zurich and the University Children's Hospital Zurich show for the first time. This discovery should be taken into account while treating children to prevent them from developing long-term psychological disorders. http://medicalxpress.com/news/2012-09-young-children-cancer-trauma-disorder.html Psychology & Psychiatry Thu, 06 Sep 2012 10:13:51 EST news266145217 In the face of mounting evidence that cancer cells communicate, cooperate and even engage in collective decision-making, biophysicists and cancer researchers at Rice University, Tel Aviv University and Johns Hopkins University are suggesting a new strategy for outsmarting cancer through its own social intelligence. http://medicalxpress.com/news/2012-09-experts-cyber-war-cancer.html Cancer Tue, 04 Sep 2012 13:17:11 EST news265983322 (Medical Xpress)—Can HIV be transformed into a biotechnological tool for improving human health? According to a CNRS team at the Architecture et Réactivité de l'ARN (RNA Architecture and Reactivity) laboratory, the answer is yes. Taking advantage of the HIV replication machinery, the researchers have been able to select a specific mutant protein. Added to a culture of tumor cells in combination with an anticancer drug, this protein improves the effectiveness of the treatment at 1/300 the normal dosage levels. Published in PLoS Genetics on 23 August 2012, these findings could lead to long-term therapeutic applications in the treatment of cancer and other pathologies. http://medicalxpress.com/news/2012-08-aids-virus-cancer.html Genetics Wed, 29 Aug 2012 07:55:40 EST news265445555 After a surgeon stitches up a patient's abdomen, costly complications -- some life-threatening -- can occur. To cut down on these postoperative problems, Johns Hopkins undergraduates have invented a disposable suturing tool to guide the placement of stitches and guard against the accidental puncture of internal organs. http://medicalxpress.com/news/2012-08-faststitch-device-future-suture.html Surgery Thu, 16 Aug 2012 10:36:00 EST news264332144 Research at Bangor University has identified a switch in cells that may help to kill tumors with heat. Prostate cancer and other localized tumors can be effectively treated by a combination of heat and an anti-cancer drug that damages the genes. Behind this novel therapy is the enigmatic ability of heat to switch off essential survival mechanisms in human cells. Although thermotherapy is now more widely used, the underlying principles are still unclear. http://medicalxpress.com/news/2012-08-cancer.html Cancer Wed, 08 Aug 2012 11:50:16 EST news263645407 The development of novel medical imaging techniques to revolutionise cancer detection and treatment will be the result of a new partnership announced today between Queen's University Belfast and Cirdan Imaging Ltd. http://medicalxpress.com/news/2012-07-queen-spin-in-company-revolutionize-cancer.html Cancer Mon, 23 Jul 2012 10:53:29 EST news262259603 Scientists at the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen have used a new method to assemble a massive catalogue of data on proteins. This gives them unprecedented insight into a process called protein phosphorylation. The research was recently published in the scientific journal Nature Communications. http://medicalxpress.com/news/2012-06-giant-raft-disease.html Medical research Thu, 28 Jun 2012 09:53:22 EST news260095995 A new device designed to more effectively produce DNA samples for genetic testing from slide-mounted tissue samples is better equipped than most models on the market to help in the diagnosis and treatment of cancer. Its University of Utah inventors say the microdissection device is an effective and reasonably priced method for removing tissue samples from microscope slides. The samples are used for genetic testing, so precision is essential. The impact could be substantial because genetic testing is becoming more popular in the fight against cancer, and so the demand for efficient dissection tools is growing. http://medicalxpress.com/news/2012-03-microdissection-device-cancer.html Cancer Thu, 29 Mar 2012 06:05:53 EST news252219922 Radiotherapy treatment (RT) after surgery for ductal carcinoma in situ (DCIS) still has a major protective effect against recurrence more than 15 years later, according to the results of an international trial. Researchers found that the use of RT in addition to surgery could reduce the chances of a local recurrence (the cancer coming back in the same breast) by 50%. Results from the trial, which has one of the longest follow-ups of a large group of patients in the world to date, will be reported today to the 8th European Breast Cancer Conference (EBCC-8). http://medicalxpress.com/news/2012-03-radiotherapy-dcis-recurrence-years.html Cancer Thu, 22 Mar 2012 05:10:41 EST news251611826 The European Association for the Study of the Liver (EASL) and the European Organisation for Research and Treatment of Cancer (EORTC) today publish their first joint Clinical Practice Guidelines (CPGs) on the management of hepatocellular carcinoma (HCC). The EASL-EORTC guidelines define the use of surveillance, diagnosis and therapeutic strategies recommended for patients with HCC. http://medicalxpress.com/news/2012-03-easl-eortc-publish-joint-clinical-guidelines.html Cancer Thu, 15 Mar 2012 07:37:29 EST news251015828 (HealthDay) -- An Internet-based educational program helps disease-free cancer survivors better manage their cancer-related fatigue (CRF), according to research published online March 12 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-03-web-based-cancer-related-fatigue.html Cancer Tue, 13 Mar 2012 15:10:01 EST news250867324 Johns Hopkins and National Taiwan University researchers have discovered more details about how an energy sensing "thermostat" protein determines whether cells will store or use their energy reserves. http://medicalxpress.com/news/2012-02-cell-energy-sensor-mechanism-linked.html Medical research Tue, 21 Feb 2012 13:22:25 EST news249052933 Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists at the Salk Institute for Biological Studies have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people. Their findings provide new ways to predict and personalize the diagnosis and treatment of cancer. http://medicalxpress.com/news/2012-02-scientists-theory-breast-cancer.html Cancer Tue, 07 Feb 2012 16:32:41 EST news247854742 Suppressing a newly identified and characterized protein involved in regulating cell division could be a novel strategy to fight certain cancers because it stops the malignant cells from dividing and causes them to die quickly, according to a study by researchers with UCLA's Jonsson Comprehensive Cancer Center. http://medicalxpress.com/news/2011-12-suppression-protein-critical-cell-division.html Cancer Fri, 09 Dec 2011 09:32:00 EST news242645511 Scientists have designed a first draft of a mathematical model that someday could guide treatment decisions for advanced prostate cancer, in part by helping doctors predict how individual patients will respond to therapy based on the biology of their tumors. http://medicalxpress.com/news/2011-11-future-prostate-cancer-treatments-math.html Cancer Mon, 21 Nov 2011 16:13:01 EST news241113985 A new strategy that takes advantage of ovarian cancer's reliance on folate appears to give relapse patients extra months of life with few side effects, researchers say. http://medicalxpress.com/news/2011-10-folate-receptors-front-door-ovarian.html Cancer Fri, 28 Oct 2011 11:11:47 EST news239019097 Researchers from the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center, have identified a cell cycle-regulated mechanism behind the transformation of normal cells into cancerous cells. The study shows the significant role that protein networks can play in a cell leading to the development of cancer. The study results, published in the October 21 issue of the journal Molecular Cell, suggest that inhibition of the CK1 enzyme may be a new therapeutic target for the treatment of cancer cells formed as a result of a malfunction in the cell's mTOR signaling pathway. http://medicalxpress.com/news/2011-10-cancer-cell.html Cancer Fri, 21 Oct 2011 17:23:02 EST news238436569 A compound initially isolated from sharks shows potential as a unique broad-spectrum human antiviral agent, according to a study led by a Georgetown University Medical Center investigator and reported in the Proceedings of the National Academy of Sciences Early Edition online September 19. http://medicalxpress.com/news/2011-09-shark-compound-potential-drug-human.html Medical research Mon, 19 Sep 2011 15:00:42 EST news235662656 Researchers at University Medical Center Utrecht, the Netherlands, have discovered a substance that has an adverse effect on nearly all types of chemotherapy - making cancer cells insensitive to the treatment. Chemotherapy often loses effectiveness over time. It is often unclear how or why this happens. http://medicalxpress.com/news/2011-09-fish-oil-effectiveness-chemotherapy.html Cancer Mon, 12 Sep 2011 12:32:47 EST news235049538