https://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. According to a Phase I study led by researchers at The University of Texas MD Anderson Cancer Center, published in Nature Medicine, the novel monoclonal antibody linavonkibart has demonstrated the potential to overcome treatment resistance to anti-PD-1 immune checkpoint inhibitors in multiple cancer types. https://medicalxpress.com/news/2026-01-immunotherapy-early-potential-resistance-immune.html Tue, 13 Jan 2026 16:49:47 EST news687545341 The fungal species Candida auris is spreading across the globe, and gaining in virulence, according to a new review by a Hackensack Meridian Center for Discovery and Innovation (CDI) scientist and colleagues. https://medicalxpress.com/news/2025-12-candida-auris-globally-drug-resistance.html Mon, 29 Dec 2025 12:50:01 EST news686234081 Adult-onset Still's disease (AOSD) is a rare inflammatory disorder. Thanks to a new initiative, AOSD is now considered to be the adult counterpart of systemic juvenile idiopathic arthritis, but in both cases the cause is unknown. People with AOSD typically have fever, arthritis, a skin rash, and systemic involvement across multiple organs. https://medicalxpress.com/news/2025-12-clinical-guidelines-gap-adult-onset.html Thu, 11 Dec 2025 20:30:03 EST news684682964 A team led by Professor Hui Wei, a pioneer in nanozyme research at Nanjing University, has unveiled an ultrasmall theranostic nanozyme with the potential to transform the diagnosis and treatment of abdominal aortic aneurysm (AAA)—a highly lethal vascular disease with limited therapeutic options. https://medicalxpress.com/news/2025-12-ultrasmall-theranostic-nanozyme-abdominal-aortic.html Thu, 04 Dec 2025 09:12:53 EST news684061944 A pioneering preclinical study has shown that CAR T cell therapy—a personalized form of immunotherapy used in cancer treatment—could be a highly effective tool against atherosclerosis, the condition where a build-up of plaque in the arteries reduces blood flow, leading to heart attacks and strokes. https://medicalxpress.com/news/2025-11-car-strategy-common-heart-disease.html Fri, 21 Nov 2025 09:11:23 EST news682938677 New results from a multicenter clinical trial show that combining immunotherapy drugs nivolumab and ipilimumab significantly improves treatment response in patients with advanced and difficult-to-treat cancers. The trial results have been pre-published in JAMA Oncology, accompanied by a commentary emphasizing the significance of the findings. https://medicalxpress.com/news/2025-11-combination-immunotherapy-rare-cancers-efficacy.html Fri, 14 Nov 2025 10:32:04 EST news682338722 Despite effective HIV medication, the immune system of people with HIV remains disrupted in the long term. https://medicalxpress.com/news/2025-11-early-hiv-drugs-immune-reprieve.html Fri, 07 Nov 2025 18:30:01 EST news681670741 Scientists at Wake Forest University School of Medicine, in collaboration with researchers at Weill Cornell Medicine, have made a breakthrough in understanding why many cancer patients develop nerve damage after chemotherapy. Their new study reveals that a stress response inside certain immune cells can trigger this debilitating side effect. This discovery could open the door to new ways to prevent or treat nerve damage in cancer patients. https://medicalxpress.com/news/2025-10-chemotherapy-nerve-linked-immune-cell.html Wed, 29 Oct 2025 16:20:03 EDT news680972655 Results of a study led by researchers at Roswell Park Comprehensive Cancer Center show that combining two types of immunotherapy—engineered T cells that secrete bispecific T cell engagers (BiTEs) and an immune checkpoint inhibitor—can alter the tumor microenvironment to launch a stronger attack against ovarian cancer and reduce the risk of relapse. https://medicalxpress.com/news/2025-10-based-immunotherapy-strategy-breakthrough-ovarian.html Mon, 27 Oct 2025 07:59:04 EDT news680770742 The aim of immunotherapy strategies is to leverage cells in the patient's own immune system to destroy tumor cells. Using a preclinical model, scientists from the Institut Pasteur and Inserm successfully stimulated an effective anti-tumor immune response by reprogramming the death of malignant B cells. They demonstrated an effective triple-therapy approach for treating forms of blood cancer such as certain lymphomas and leukemias which affect B cells. The study was published on August 15 in the journal Science Advances. https://medicalxpress.com/news/2025-10-blood-cancer-scientists-reprogram-cell.html Fri, 10 Oct 2025 12:54:04 EDT news679319641 Treatments for cancer are continuously improving, but they can still cause debilitating, even fatal, side effects. Immune checkpoint inhibitors, or ICIs, have revolutionized cancer therapy, yet their use can trigger a rare but deadly side effect that affects the heart: myocarditis. ICI-related myocarditis has a mortality of up to 40%. https://medicalxpress.com/news/2025-10-liquid-biopsy-early-ici-myocarditis.html Fri, 10 Oct 2025 11:30:03 EDT news679312561 New research reveals that inflammatory responses may play a role in different types of fatigue experienced by many people with cancer. The findings are published in Cancer. https://medicalxpress.com/news/2025-10-inflammation-combat-fatigue-people-early.html Mon, 06 Oct 2025 03:10:01 EDT news678700081 Researchers at Moffitt Cancer Center have reported encouraging results from a phase 1B clinical trial showing that the immunotherapy drug avelumab, when combined with whole brain radiotherapy, may provide a safe and effective treatment option for patients with leptomeningeal disease, one of the most aggressive and difficult-to-treat complications of advanced cancer. https://medicalxpress.com/news/2025-09-clinical-trial-treatment-patients-leptomeningeal.html Tue, 30 Sep 2025 16:00:04 EDT news678466802 Molecular profiling has transformed cancer care, but 30% of high-risk pediatric cancers do not have actionable therapeutic targets, limiting personalized treatment options and negatively affecting survival outcomes. https://medicalxpress.com/news/2025-09-zebrafish-fast-effective-guidance-personalized.html Wed, 24 Sep 2025 15:11:54 EDT news677945509 Debate continues over the role of artificial intelligence in treating mental health conditions, but new research shows that machine learning models can help predict whether a person might benefit from certain treatments. https://medicalxpress.com/news/2025-09-machine-mental-health-patients-outcomes.html Thu, 18 Sep 2025 10:17:03 EDT news677409421 Microbes inside cancerous tumors can influence the spread of disease and the effectiveness of treatment. Those roles make them appealing targets for new therapies and offer ways to better predict risk. Tumor microbiota-based tools could help identify high-risk patients and people most susceptible to metastases, and possibly be used to improve prognosis tools, report a group of microbiologists at Nankai University in Tianjin, China. https://medicalxpress.com/news/2025-08-gastrointestinal-tumor-microbes-prognosis-treatment.html Thu, 28 Aug 2025 09:04:03 EDT news675590641 The most common cancer-causing strain of human papillomavirus (HPV), HPV16, undermines the body's defenses by reprogramming immune cells surrounding the tumor, according to new research from the Keck School of Medicine of USC. https://medicalxpress.com/news/2025-08-hpv-reprograms-immune-cells-cancer.html Tue, 19 Aug 2025 11:00:03 EDT news674726642 Adding a MET gene inhibitor enhances the effect of combined chemotherapy and immunotherapy in small cell lung cancer (SCLC), according to a multicenter study led by the Hospital del Mar Research Institute, in collaboration with researchers from the CIBERONC cancer research network. https://medicalxpress.com/news/2025-08-gene-inhibitor-boost-immunotherapy-aggressive.html Tue, 12 Aug 2025 12:36:03 EDT news674220961 A study published in Cell Reports Medicine reports a scalable, data-driven computational framework for designing combinatorial immunotherapies, offering hope for patients with poor responses to current immunotherapies. https://medicalxpress.com/news/2025-08-tool-compounds-cancer-immunotherapy-effectiveness.html Wed, 06 Aug 2025 09:13:03 EDT news673690382 A new study by Indiana University School of Medicine researchers has revealed a breakthrough in the fight against acute myeloid leukemia, one of the most aggressive and fatal blood cancers in adults. The discovery of a previously unrecognized immune cell could lead to new therapies that are less treatment-resistant than current options for patients—meaning higher survival rates for people with blood cancers. https://medicalxpress.com/news/2025-07-unique-immune-cell-linked-aggressive.html Tue, 22 Jul 2025 15:30:26 EDT news672417015 In a newly published article in Nature Genetics, researchers from the University of Chicago have identified tumor aneuploidy—an imbalance in the number of chromosomes—as a powerful biomarker associated with resistance to immunotherapy across cancer types. The study emphasizes how combining immunotherapy with radiation may help overcome the issue of therapy resistance, offering a new framework for predicting treatment response and personalizing cancer therapy. https://medicalxpress.com/news/2025-07-chromosomal-abnormality-scores-path-personalized.html Wed, 09 Jul 2025 15:56:54 EDT news671295409 Altum Sequencing, a start-up supported by the C3N-IA Science Park at Universidad Carlos III de Madrid (UC3M) and specialized in oncology, has developed a tool to monitor treatment response in patients with solid tumors from a simple blood sample. This advance could represent a turning point in post-treatment follow-up. https://medicalxpress.com/news/2025-06-technology-breast-cancer-relapses-years.html Thu, 19 Jun 2025 16:20:01 EDT news669568246 At the start of the COVID-19 pandemic, information began to trickle in about who was at higher risk of a dangerous outcome from infection: men, those over 65, smokers, those with obesity. It turns out these seemingly unrelated categories of people have one thing in common: a signature of immune dysregulation. https://medicalxpress.com/news/2025-06-immune-dysregulation-prior-infection-severe.html Tue, 17 Jun 2025 13:50:04 EDT news669387002 The COVID-19 pandemic caused by SARS-CoV-2 infection is marked by excessive inflammation of several organs, leading to multi-organ failure. The recognition of the virus by our bodies triggers severe immune responses, causing a "cytokine storm," which can lead to acute lung injury and acute respiratory distress syndrome. https://medicalxpress.com/news/2025-06-rheumatoid-arthritis-drug-excessive-inflammation.html Tue, 10 Jun 2025 16:56:04 EDT news668793362 Maintaining muscle mass has proven to be crucial for patients undergoing cancer treatment. Studies have shown that individuals with more muscle tend to respond better to therapies such as chemotherapy and radiotherapy. They also have a lower risk of complications and experience more effective recovery. https://medicalxpress.com/news/2025-05-women-muscle-mass-worse-prognosis.html Wed, 28 May 2025 16:32:44 EDT news667668759 Science and society collaboration is essential for scientific progress, especially in the health and biomedical fields where basic researchers, clinicians and patients are involved, as shown by the initial results of D-BIOMARK. This clinical trial against breast cancer has analyzed the potential anti-tumor role of denosumab, a drug already in use in the prevention of metastasis-related osteoporosis and bone lesions. https://medicalxpress.com/news/2025-05-rediscovering-denosumab-osteoporosis-medication-treatment.html Fri, 16 May 2025 12:14:04 EDT news666616442 Considered to be one of the greatest revolutions in cancer treatment, immunotherapy enhances the immune system's ability to target and destroy cancer cells efficiently. One of the key challenges in immunotherapy is the uncertainty regarding patients' responses—not all patients respond to the treatment, and some may experience side effects without meaningful therapeutic gain. Therefore, there is a need to identify biomarkers that can predict treatment effectiveness based on individual patient data. https://medicalxpress.com/news/2025-05-genetic-signature-cells-personalization-immunotherapy.html Thu, 08 May 2025 12:40:03 EDT news665926801 A new topical gel called LUT014 successfully reduced the severity of a painful acne‐like rash that commonly occurs as a side effect of targeted therapy with epidermal growth factor receptor (EGFR) inhibitors for colorectal cancer, according to a clinical trial led by researchers at The University of Texas MD Anderson Cancer Center. https://medicalxpress.com/news/2025-04-topical-gel-relieves-painful-skin.html Mon, 28 Apr 2025 10:42:04 EDT news665055721 A new study led by the University of Oxford has revealed that a common and usually harmless virus may positively influence how skin cancer patients respond to current treatments. https://medicalxpress.com/news/2025-04-common-virus-skin-cancer-treatment.html Wed, 23 Apr 2025 14:19:05 EDT news664636741 Research has shed light on how a new type of antibody treatment reactivates patients' immune cells to fight ovarian cancer. The research, from the group of Professor Sophia Karagiannis at King's College London, could help to better understand the responses of patients who receive this type of therapy. https://medicalxpress.com/news/2025-04-immune-reactivating-antibody-therapy-ovarian.html Thu, 10 Apr 2025 12:38:05 EDT news663507482